pI: 7.9101 |
Length (AA): 568 |
MW (Da): 64549 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
189 | 284 | 2han (B) | 2 | 87 | 77.00 | 0 | 1 | 0.923714 | -0.05 |
192 | 518 | 4nqa (B) | 85 | 455 | 38.00 | 0 | 1 | 0.794404 | 0.71 |
349 | 506 | 3n00 (A) | 294 | 610 | 27.00 | 0.00005 | 1 | 0.662669 | -1.22 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_134445)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_46530 | ecdysteroid receptor |
Drosophila melanogaster | Dmel_CG1765 | Ecdysone receptor |
Homo sapiens | ENSG00000025434 | nuclear receptor subfamily 1, group H, member 3 |
Loa Loa (eye worm) | LOAG_04613 | hypothetical protein |
Mus musculus | ENSMUSG00000002108 | nuclear receptor subfamily 1, group H, member 3 |
Onchocerca volvulus | OVOC9104 | Bile acid receptor homolog |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Lucilia cuprina | Ecdysone receptor | Compounds | References |
Homo sapiens | nuclear receptor subfamily 1, group H, member 3 | Compounds | References |
Chironomus tentans | Ecdysone receptor | Compounds | References |
Choristoneura fumiferana | Ecdysone receptor | Compounds | References |
Anthonomus grandis | Ecdysone receptor | Compounds | References |
Bombyx mori | Ecdysone receptor | Compounds | References |
Aedes aegypti | Ecdysone receptor | Compounds | References |
Heliothis virescens | Ecdysone receptor | Compounds | References |
Spodoptera frugiperda | Ecdysone receptor | Compounds | References |
Spodoptera littoralis | Ecdysone receptor | Compounds | References |
Drosophila melanogaster | Ecdysone receptor | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Danio rerio | Vitamin D3 receptor A | 453 aa | 28.1% | 374 aa | Compounds | References |
Sus scrofa | Vitamin D3 receptor | 427 aa | 28.9% | 401 aa | Compounds | References |
Rattus norvegicus | Nuclear receptor subfamily 1 group I member 2 | 431 aa | 26.9% | 394 aa | Compounds | References |
Mesocricetus auratus | Peroxisome proliferator activated receptor alpha | 468 aa | 26.1% | 375 aa | Compounds | References |
Choristoneura fumiferana | Ecdysone receptor | 513 aa | 29.9% | 411 aa | Compounds | References |
Bos taurus | Vitamin D receptor | 426 aa | 28.1% | 399 aa | Compounds | References |
Nezara viridula | Ecdysone receptor | 444 aa | 39.7% | 365 aa | Compounds | References |
Rattus norvegicus | Vitamin D receptor | 423 aa | 28.5% | 397 aa | Compounds | References |
Rattus norvegicus | Peroxisome proliferator-activated receptor alpha | 468 aa | 25.1% | 375 aa | Compounds | References |
Gallus gallus | Vitamin D receptor | 451 aa | 28.9% | 398 aa | Compounds | References |