pI: 6.0814 |
Length (AA): 1137 |
MW (Da): 128607 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 8 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
123 | 239 | 5g4p (A) | 6 | 124 | 33.00 | 0.00000000099 | 0.99 | 0.478502 | -0.36 |
131 | 281 | 5g4p (A) | 14 | 185 | 28.00 | 0 | 1 | 0.389406 | -0.32 |
136 | 288 | 2r2i (A) | 9 | 177 | 25.00 | 0 | 1 | 0.415165 | -0.46 |
141 | 212 | 2wcb (A) | 4 | 85 | 21.00 | 0 | 0.46 | 0.286925 | -1.23 |
294 | 531 | 3jyu (A) | 13 | 227 | 27.00 | 0.0023 | 1 | 0.101923 | 1.28 |
557 | 742 | 2y6e (D) | 300 | 778 | 48.00 | 0 | 1 | 0.704188 | -0.2 |
560 | 668 | 2ayn (A) | 105 | 219 | 32.00 | 0.000057 | 0.77 | 0.381466 | -0.78 |
1104 | 1134 | 3i3t (A) | 508 | 538 | 39.00 | 0.74 | 0.19 | 0.312265 | 0.69 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_131366)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_17230 | Ubiquitin carboxyl-terminal hydrolase family protein |
Caenorhabditis elegans | CELE_ZK328.1 | Protein CYK-3, isoform B |
Drosophila melanogaster | Dmel_CG8334 | CG8334 gene product from transcript CG8334-RB |
Echinococcus granulosus | EgrG_000915300 | ubiquitin carboxyl terminal hydrolase 4 |
Entamoeba histolytica | EHI_119600 | ubiquitin carboxyl-terminal hydrolase domain containing protein |
Echinococcus multilocularis | EmuJ_000915300 | ubiquitin carboxyl terminal hydrolase 4 |
Homo sapiens | ENSG00000275954 | TBC1 domain family, member 3F |
Homo sapiens | ENSG00000274512 | TBC1 domain family, member 3L |
Homo sapiens | 84669 | ubiquitin specific peptidase 32 |
Homo sapiens | ENSG00000274419 | TBC1 domain family member-like |
Homo sapiens | 102723859 | TBC1 domain family member-like |
Homo sapiens | ENSG00000129204 | ubiquitin specific peptidase 6 |
Homo sapiens | ENSG00000274611 | TBC1 domain family, member 3 |
Homo sapiens | ENSG00000274933 | TBC1 domain family member-like |
Homo sapiens | ENSG00000278299 | TBC1 domain family, member 3C |
Homo sapiens | 100510707 | TBC1 domain family, member 3J |
Homo sapiens | ENSG00000274808 | TBC1 domain family, member 3B |
Homo sapiens | ENSG00000260287 | TBC1 domain family member-like |
Homo sapiens | 101060351 | TBC1 domain family, member 3K |
Homo sapiens | ENSG00000274226 | TBC1 domain family, member 3H |
Loa Loa (eye worm) | LOAG_07846 | ubiquitin carboxyl-terminal hydrolase |
Mus musculus | ENSMUSG00000000804 | ubiquitin specific peptidase 32 |
Schmidtea mediterranea | mk4.022087.00 | Ubiquitin carboxyl-terminal hydrolase 32 |
Schmidtea mediterranea | mk4.002275.08 | Ubiquitin carboxyl-terminal hydrolase 6 |
Schmidtea mediterranea | mk4.002275.06 | |
Schmidtea mediterranea | mk4.002275.07 | |
Schmidtea mediterranea | mk4.010463.00 | |
Schmidtea mediterranea | mk4.002275.04 | Ubiquitin carboxyl-terminal hydrolase 6 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_ZK328.1 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_ZK328.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Bos taurus | Calmodulin | 149 aa | 17.9% | 140 aa | Compounds | References |