Detailed view for Bm1_53150

Basic information

TDR Targets ID: 234131
Brugia malayi, FXNA
Source Database / ID:  GenBank

pI: 7.6833 | Length (AA): 902 | MW (Da): 102588 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 9

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04389   Peptidase family M28

Gene Ontology

Mouse over links to read term descriptions.
GO:0008233   peptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
70 351 3si2 (A) 52 355 21.00 0 1 0.388939 -0.05
74 351 4fuu (A) 40 326 18.00 0 0.78 0.382504 -0.35
76 355 1tkj (A) 7 275 15.00 0 1 0.419721 -0.28
158 227 4f9u (A) 96 173 36.00 0.012 0.65 0.306105 0.22

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128724)

Species Accession Gene Product
Arabidopsis thaliana AT5G20660   Zn-dependent exopeptidases superfamily protein
Arabidopsis thaliana AT1G67420   Zn-dependent exopeptidase-like protein
Brugia malayi Bm1_53150   FXNA
Caenorhabditis elegans CELE_B0495.7   Protein B0495.7
Caenorhabditis elegans CELE_C44B7.11   Protein C44B7.11
Drosophila melanogaster Dmel_CG33012   CG33012 gene product from transcript CG33012-RC
Drosophila melanogaster Dmel_CG10073   CG10073 gene product from transcript CG10073-RC
Drosophila melanogaster Dmel_CG30043   CG30043 gene product from transcript CG30043-RA
Drosophila melanogaster Dmel_CG9416   CG9416 gene product from transcript CG9416-RB
Drosophila melanogaster Dmel_CG10081   CG10081 gene product from transcript CG10081-RA
Drosophila melanogaster Dmel_CG11961   CG11961 gene product from transcript CG11961-RB
Drosophila melanogaster Dmel_CG10062   CG10062 gene product from transcript CG10062-RC
Drosophila melanogaster Dmel_CG10051   CG10051 gene product from transcript CG10051-RA
Drosophila melanogaster Dmel_CG13160   CG13160 gene product from transcript CG13160-RB
Drosophila melanogaster Dmel_CG30049   CG30049 gene product from transcript CG30049-RA
Drosophila melanogaster Dmel_CG30047   CG30047 gene product from transcript CG30047-RA
Echinococcus granulosus EgrG_000010300   endoplasmic reticulum metallopeptidase 1
Echinococcus multilocularis EmuJ_000010300   endoplasmic reticulum metallopeptidase 1
Echinococcus multilocularis EmuJ_000890300   endoplasmic reticulum metallopeptidase 1
Homo sapiens ENSG00000099219   endoplasmic reticulum metallopeptidase 1
Loa Loa (eye worm) LOAG_03452   hypothetical protein
Mus musculus 226090   endoplasmic reticulum metallopeptidase 1
Oryza sativa 4342962   Os07g0295800
Oryza sativa 4336420   Os04g0519900
Onchocerca volvulus OVOC12752   Fxna peptidase homolog
Onchocerca volvulus OVOC1753   Fxna peptidase homolog
Onchocerca volvulus OVOC10368   Fxna peptidase homolog
Schistosoma japonicum Sjp_0060780   Endoplasmic reticulum metallopeptidase 1, putative
Schistosoma mansoni Smp_175220   Fxna peptidase (M28 family)
Schmidtea mediterranea mk4.000129.05   Fxna peptidase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0608 0.4599 0
0.0153 0.661 0.853
0.0207 0.6634 0.6634
0.0182 0.3513 0.3513
0.0225 0.644 1
0.0582 0.5175 0.5175
0.0205 0.4749 0.5759
0.0267 0.5372 0.5189
0.0172 0.2618 0.2618
0.0284 0.337 0.4693
0.045 0.4215 0.4215
0.0385 0.3517 0.2764
0.045 0.4215 0.4215
0.045 0.2824 0.2824
0.0385 0.3517 0.2764
0.0429 0.4597 0.4595
0.0318 0.3394 0.3391
0.0233 0.356 0.3544
0.0275 0.4652 0.4652
0.0318 0.3394 0.3391
0.0249 0.436 0.436
0.0233 0.356 0.3544
0.0205 0.4749 0.5759
0.0582 0.5175 0.5175

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_53150 (Brugia malayi), FXNA
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