pI: 6.2273 |
Length (AA): 229 |
MW (Da): 23551 |
Paralog Number:
6
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
NA% percentile | amastigotes, metacyclic. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_131023)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_25735 | dihydropteridine reductase-like |
Caenorhabditis elegans | CELE_T03F6.1 | Protein QDPR-1 |
Dictyostelium discoideum | DDB_G0272684 | dihydropteridine reductase |
Drosophila melanogaster | Dmel_CG4665 | Dihydropteridine reductase |
Echinococcus granulosus | EgrG_000819200 | NADP binding domain |
Echinococcus multilocularis | EmuJ_000819200 | NAD(P) binding domain |
Homo sapiens | ENSG00000151552 | quinoid dihydropteridine reductase |
Leishmania braziliensis | LbrM.20.3970 | quinonoid dihydropteridine reductase |
Leishmania donovani | LdBPK_044270.1 | hypothetical protein, conserved |
Leishmania infantum | LinJ.34.4270 | quinonoid dihydropteridine reductase |
Leishmania major | LmjF.34.4390 | quinonoid dihydropteridine reductase |
Leishmania major | LmjF.34.4330 | quinonoid dihydropteridine reductase |
Leishmania major | LmjF.34.4450 | quinonoid dihydropteridine reductase |
Leishmania major | LmjF.34.4480 | quinonoid dihydropteridine reductase |
Leishmania major | LmjF.34.4420 | quinonoid dihydropteridine reductase |
Leishmania major | LmjF.34.4510 | quinonoid dihydropteridine reductase |
Leishmania major | LmjF.34.4360 | quinonoid dihydropteridine reductase |
Leishmania mexicana | LmxM.33.4330 | quinonoid dihydropteridine reductase |
Loa Loa (eye worm) | LOAG_02547 | dihydropteridine reductase-PC |
Mus musculus | ENSMUSG00000015806 | quinoid dihydropteridine reductase |
Neospora caninum | NCLIV_014630 | Novel protein similar to quinoid dihydropteridine reductase (QDPR, zgc:112405), related |
Schistosoma japonicum | Sjp_0002580 | ko:K00357 dihydropteridine reductase [EC1.5.1.34], putative |
Schistosoma mansoni | Smp_086210 | dihydropteridine reductase |
Schmidtea mediterranea | mk4.020580.00 | |
Schmidtea mediterranea | mk4.019996.00 | |
Schmidtea mediterranea | mk4.001430.06 | Dihydropteridine reductase |
Trypanosoma cruzi | TcCLB.510689.20 | quinonoid dihydropteridine reductase, putative |
Toxoplasma gondii | TGME49_285750 | 6,7-dihydropteridine reductase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_285750 | Toxoplasma gondii | Essentiality uncertain | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.6
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | quinoid dihydropteridine reductase | Compounds | References |
Rattus norvegicus | Dihydropteridine reductase | Compounds | References |