Detailed view for Bm1_22500

Basic information

TDR Targets ID: 234359
Brugia malayi, hypothetical protein
Source Database / ID:  GenBank

pI: 6.0874 | Length (AA): 614 | MW (Da): 72113 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
206 602 4l6y (B) 32 419 13.00 0 0.92 0.61758 1.15
222 385 5cwh (A) 4 159 11.00 0.17 0.11 0.407301 -0.9

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129428)

Species Accession Gene Product
Arabidopsis thaliana AT3G54380   SAC3/GANP/Nin1/mts3/eIF-3 p25 family protein
Arabidopsis thaliana AT3G06290   SAC3/GANP/Nin1/mts3/eIF-3 p25 family protein
Brugia malayi Bm1_22500   hypothetical protein
Candida albicans CaO19.1555   corresponds to C-terminus of S. cerevisiae SAC3 and allelic CaP19.9129
Candida albicans CaO19.1556   similar to regulator of leucine permease
Candida albicans CaO19.9129   similar to regulator of leucine permease
Caenorhabditis elegans CELE_F20D12.2   Protein F20D12.2
Dictyostelium discoideum DDB_G0274789   hypothetical protein
Drosophila melanogaster Dmel_CG32562   CG32562 gene product from transcript CG32562-RA
Echinococcus granulosus EgrG_000794600   80 kDa MCM3 associated protein
Echinococcus multilocularis EmuJ_000794600   80 kDa MCM3 associated protein
Homo sapiens ENSG00000160294   minichromosome maintenance complex component 3 associated protein
Loa Loa (eye worm) LOAG_06026   hypothetical protein
Mus musculus ENSMUSG00000001150   minichromosome maintenance deficient 3 (S. cerevisiae) associated protein
Oryza sativa 4332850   Os03g0352200
Saccharomyces cerevisiae YDR159W   Sac3p
Schistosoma japonicum Sjp_0107960   hypothetical protein
Schistosoma japonicum Sjp_0047730   similar to 80 kDa MCM3-associated protein, putative
Schistosoma japonicum Sjp_0047720   IPR001611,Leucine-rich repeat,domain-containing
Schistosoma mansoni Smp_180900   hypothetical protein
Schmidtea mediterranea mk4.017120.01  
Schmidtea mediterranea mk4.020505.00  
Trichomonas vaginalis TVAG_180540   80 kD MCM3-associated protein, putative
Trichomonas vaginalis TVAG_216740   80 kD MCM3-associated protein, putative

Essentiality

Bm1_22500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F20D12.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_F20D12.2 Caenorhabditis elegans larval lethal wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_22500 (Brugia malayi), hypothetical protein
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