Detailed view for Bm1_17150

Basic information

TDR Targets ID: 234446
Brugia malayi, hypothetical protein
Source Database / ID:  GenBank

pI: 7.3938 | Length (AA): 2268 | MW (Da): 257759 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00373   FERM central domain
PF05902   4.1 protein C-terminal domain (CTD)
PF09379   FERM N-terminal domain
PF09380   FERM C-terminal PH-like domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0019898   extrinsic to membrane  
GO:0005856   cytoskeleton  
GO:0005737   cytoplasm  
GO:0008092   cytoskeletal protein binding  
GO:0005488   binding  
GO:0005198   structural molecule activity  
GO:0003779   actin binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128746)

Species Accession Gene Product
Brugia malayi Bm1_17150   hypothetical protein
Caenorhabditis elegans CELE_ZK270.2   Protein FRM-1, isoform E
Drosophila melanogaster Dmel_CG11949   coracle
Echinococcus granulosus EgrG_000468600   protein 4.1
Echinococcus multilocularis EmuJ_000468600  
Homo sapiens ENSG00000079819   erythrocyte membrane protein band 4.1-like 2
Homo sapiens ENSG00000082397   erythrocyte membrane protein band 4.1-like 3
Homo sapiens ENSG00000159023   erythrocyte membrane protein band 4.1
Homo sapiens ENSG00000088367   erythrocyte membrane protein band 4.1-like 1
Loa Loa (eye worm) LOAG_05898   hypothetical protein
Loa Loa (eye worm) LOAG_05899   hypothetical protein
Mus musculus ENSMUSG00000027624   erythrocyte protein band 4.1-like 1
Mus musculus ENSMUSG00000024044   erythrocyte protein band 4.1-like 3
Mus musculus ENSMUSG00000028906   erythrocyte protein band 4.1
Mus musculus ENSMUSG00000019978   erythrocyte protein band 4.1-like 2
Onchocerca volvulus OVOC1460  
Schistosoma japonicum Sjp_0300810   ko:K06107 erythrocyte membrane protein band 4.1, putative
Schistosoma japonicum Sjp_0049960   Acetylcholine receptor subunit alpha-L1 precursor, putative
Schistosoma japonicum Sjp_0105520   expressed protein
Schistosoma mansoni Smp_155470   hypothetical protein
Schistosoma mansoni Smp_155460   hypothetical protein
Schmidtea mediterranea mk4.003868.00   Protein 4.1 homolog
Schmidtea mediterranea mk4.004252.01   Putative 4.1 G protein
Schmidtea mediterranea mk4.008770.02   Putative 4.1 G protein
Schmidtea mediterranea mk4.012491.01  
Trichomonas vaginalis TVAG_387960   conserved hypothetical protein

Essentiality

Bm1_17150 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_ZK270.2 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_17150 (Brugia malayi), hypothetical protein
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