Detailed view for Bm1_37890

Basic information

TDR Targets ID: 234536
Brugia malayi, Cadps2 protein
Source Database / ID:  GenBank

pI: 6.0251 | Length (AA): 1390 | MW (Da): 159146 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00169   PH domain
PF06292   Domain of Unknown Function (DUF1041)

Gene Ontology

Mouse over links to read term descriptions.
GO:1990504   GO:dense core granule exocytosis  

GO:0016079   synaptic vesicle exocytosis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
376 1298 5ue8 (A) 606 1488 16.00 0 1 0.370029 1.33
457 574 3kwu (A) 691 818 19.00 0 0.34 0.251792 -0.82
576 696 1wi1 (A) 5 122 60.00 0 1 0.76795 -0.6

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130979)

Species Accession Gene Product
Brugia malayi Bm1_37890   Cadps2 protein
Drosophila melanogaster Dmel_CG33653   Calcium activated protein for secretion
Echinococcus granulosus EgrG_000813100   calcium dependent secretion activator 1
Echinococcus granulosus EgrG_000216500   calcium dependent secretion activator 1
Echinococcus granulosus EgrG_000216400   calcium dependent secretion activator 1
Echinococcus multilocularis EmuJ_000813100   calcium dependent secretion activator 1
Echinococcus multilocularis EmuJ_000216400   calcium dependent secretion activator 1
Homo sapiens ENSG00000081803   Ca++-dependent secretion activator 2
Homo sapiens ENSG00000163618   Ca++-dependent secretion activator
Loa Loa (eye worm) LOAG_10742   hypothetical protein
Loa Loa (eye worm) LOAG_09429   hypothetical protein
Mus musculus ENSMUSG00000054423   Ca2+-dependent secretion activator
Mus musculus ENSMUSG00000017978   Ca2+-dependent activator protein for secretion 2
Schistosoma japonicum Sjp_0006540   Calcium-dependent secretion activator 2, putative
Schistosoma japonicum Sjp_0067210   Calcium-dependent secretion activator 1, putative
Schistosoma japonicum Sjp_0311120   Calcium-dependent secretion activator 1, putative
Schistosoma japonicum Sjp_0087960   Calcium-dependent secretion activator 1, putative
Schistosoma mansoni Smp_102360   calcium-dependent activator protein for secretion
Schistosoma mansoni Smp_137670   calcium-dependent activator protein for secretion
Schistosoma mansoni Smp_173190   calcium-dependent activator protein for secretion
Schmidtea mediterranea mk4.000682.06  
Schmidtea mediterranea mk4.014644.01   Putative calcium-dependent activator protein for secretion
Schmidtea mediterranea mk4.014644.00  
Schmidtea mediterranea mk4.007092.01   Calcium-dependent secretion activator
Schmidtea mediterranea mk4.000682.05  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_37890 (Brugia malayi), Cadps2 protein
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