Detailed view for Bm1_41015

Basic information

TDR Targets ID: 234677
Brugia malayi, Smad1

Source Database / ID:  GenBank

pI: 7.0969 | Length (AA): 421 | MW (Da): 47940 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03165   MH1 domain
PF03166   MH2 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0006355   regulation of transcription, DNA-dependent  
GO:0005667   transcription factor complex  
GO:0005622   intracellular  
GO:0005515   protein binding  
GO:0003700   transcription factor activity  
GO:0007179   transforming growth factor beta receptor signaling pathway  

Metabolic Pathways

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 132 1ozj (A) 7 132 60.00 0 1 1.08676 -1.41
6 132 3kmp (A) 9 132 76.00 0 1 1.22476 -0.89
56 124 4xst (E) 217 303 28.00 0.74 0.4 0.257995 0.79
201 411 1dd1 (B) 287 544 42.00 0 1 0.950288 -1.06
215 418 1khx (A) 265 464 54.00 0 1 1.22266 -1.35
220 421 3gmj (D) 257 455 62.00 0 1 1.31991 -1.36

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein


No expression data available for this gene


Ortholog group members (OG5_129872)

Species Accession Gene Product
Brugia malayi Bm1_41015   Smad1
Caenorhabditis elegans CELE_R13F6.9   Protein SMA-3
Caenorhabditis elegans CELE_ZK370.2   Protein SMA-2
Drosophila melanogaster Dmel_CG12399   Mothers against dpp
Echinococcus granulosus EgrG_001018300   mothers against decapentaplegic 5
Echinococcus multilocularis EmuJ_001018300   mothers against decapentaplegic 5
Homo sapiens ENSG00000170365   SMAD family member 1
Homo sapiens ENSG00000120693   SMAD family member 9
Homo sapiens ENSG00000113658   SMAD family member 5
Loa Loa (eye worm) LOAG_07723   Smad1
Mus musculus ENSMUSG00000027796   SMAD family member 9
Mus musculus ENSMUSG00000021540   SMAD family member 5
Mus musculus ENSMUSG00000031681   SMAD family member 1
Schistosoma japonicum Sjp_0006780   ko:K04676 SMAD, mothers against DPP 1/5/8, putative
Schistosoma japonicum Sjp_0311510   Mothers against decapentaplegic homolog 5, putative
Schistosoma mansoni Smp_013060   smad1 5 8 and
Schmidtea mediterranea mk4.012997.02   Protein mothers against dpp
Schmidtea mediterranea mk4.015778.00   Protein mothers against dpp
Schmidtea mediterranea mk4.034364.00   Protein mothers against dpp
Schmidtea mediterranea mk4.033329.00   Protein mothers against dpp
Schmidtea mediterranea mk4.000512.03   Smad1
Schmidtea mediterranea mk4.012997.01   Protein mothers against dpp
Schmidtea mediterranea mk4.015815.00   Mothers against decapentaplegic homolog 1
Schmidtea mediterranea mk4.031371.00   Protein mothers against dpp
Schmidtea mediterranea mk4.013605.00   Protein mothers against dpp


No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model


Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_41015 (Brugia malayi), Smad1
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