Detailed view for Bm1_27260

Basic information

TDR Targets ID: 235139
Brugia malayi, TATA binding protein associated factor
Source Database / ID:  GenBank

pI: 6.2476 | Length (AA): 1096 | MW (Da): 125515 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01433   Peptidase family M1 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005669   transcription factor TFIID complex  
GO:0005488   binding  
GO:0008270   zinc ion binding  
GO:0008237   metallopeptidase activity  

Metabolic Pathways

Basal transcription factors (KEGG)

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
34 617 4kx7 (A) 80 602 15.00 0 1 0.617547 0.15
46 1000 5mj6 (A) 167 1031 12.00 0 1 0.87405 0.47
108 874 3mdj (A) 78 838 16.00 0 1 0.691018 1.03
301 508 5ab0 (A) 283 482 22.00 0.00033 1 0.433781 -0.15
326 1096 1z3h (A) 123 927 12.00 0 0.81 0.723667 0.66
639 749 2v5r (A) 19 141 33.00 0.39 0.12 -0.0157226 2.28
793 1068 4v3r (A) 14 292 12.00 0.013 0.91 0.428525 -0.56
1038 1084 4jw2 (A) 13 59 9.00 0.076 0 0.207583 -0.95

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129043)

Species Accession Gene Product
Arabidopsis thaliana AT1G73960   TBP-associated factor 2
Brugia malayi Bm1_27260   TATA binding protein associated factor
Candida albicans CaO19.9682   similar to RNA polymerase II transcriptional activator
Candida albicans CaO19.9683   similar to S. cerevisiae TAF2 (YCR042C) RNA polymerase II transcriptional activator
Candida albicans CaO19.2135   similar to RNA polymerase II transcriptional activator
Candida albicans CaO19.2136   similar to S. cerevisiae TAF2 (YCR042C) RNA polymerase II transcriptional activator
Caenorhabditis elegans CELE_Y37E11B.4   Protein TAF-2
Dictyostelium discoideum DDB_G0292724   TFIID subunit
Drosophila melanogaster Dmel_CG6711   TBP-associated factor 2
Echinococcus granulosus EgrG_000101000   transcription initiation factor TFIID subunit 2
Entamoeba histolytica EHI_108470   hypothetical protein
Echinococcus multilocularis EmuJ_000101000   transcription initiation factor TFIID subunit 2
Homo sapiens ENSG00000064313   TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
Loa Loa (eye worm) LOAG_05933   TATA binding protein associated factor
Mus musculus ENSMUSG00000037343   TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor
Oryza sativa 4347029   Os09g0410300
Saccharomyces cerevisiae YCR042C   Taf2p
Schistosoma japonicum Sjp_0022540   ko:K03128 transcription initiation factor TFIID subunit D2, putative
Schistosoma mansoni Smp_128960   Tata binding protein associated factor (M01 family)
Schmidtea mediterranea mk4.001548.08   Transcription initiation factor TFIID subunit 2
Schmidtea mediterranea mk4.009719.01  
Schmidtea mediterranea mk4.020921.01   Transcription initiation factor TFIID subunit 2
Schmidtea mediterranea mk4.009719.05   Transcription initiation factor TFIID subunit 2
Schmidtea mediterranea mk4.009719.02  
Schmidtea mediterranea mk4.015870.00   Transcription initiation factor TFIID subunit 2
Schmidtea mediterranea mk4.021599.00   Transcription initiation factor TFIID subunit 2
Schmidtea mediterranea mk4.017228.01   Transcription initiation factor TFIID subunit 2
Schmidtea mediterranea mk4.021336.01   Transcription initiation factor TFIID subunit 2
Trichomonas vaginalis TVAG_364490   tfiid 150 kD subunit, putative

Essentiality

Bm1_27260 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y37E11B.4 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0144 0.3242 0.3242
0.0218 0.2944 0.3419
0.0349 0.3134 0.3134
0.0143 0.324 0.324
0.0208 0.3428 0.3428
0.0218 0.2944 0.3419
0.0143 0.3112 0.3189
0.0159 0.3261 0.3261
0.035 0.3095 0.2641
0.0099 0.2939 0.2801
0.0208 0.3428 0.3428
0.0143 0.3112 0.3189
0.0117 0.258 0.2757
0.0159 0.3261 0.3261
0.0144 0.3242 0.3242
0.0289 0.3347 0.3347
0.0132 0.3219 0.3219
0.0323 0.34 0.3347
0.0257 0.3331 0.3252
0.0254 0.3435 0.3399
0.0075 0.2774 0.2774
0.023 0.3439 0.3439
0.0301 0.3441 0.3441
0.0254 0.3435 0.3399
0.0143 0.324 0.324
0.0575 0.3459 0.3459
0.0160081 0.282775 0.282084
0.0241 0.333 0.333
0.0205 0.3237 0.3292
0.0105 0.3146 0.3146
0.0174 0.3281 0.3281
0.0105 0.3195 0.3143
0.0216 0.2872 0.2872
0.0254 0.3435 0.3399
0.0159 0.3259 0.3259
0.0254 0.3435 0.3399
0.0143 0.324 0.324
0.0218 0.2944 0.3419
0.012 0.3186 0.3186
0.0301 0.3401 0.3386
0.0104 0.315 0.315
0.0301 0.3418 0.3418
0.0159 0.3259 0.3259
0.0087 0.3157 0.3098
0.0091 0.2942 0.2942

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Bm1_27260 (Brugia malayi), TATA binding protein associated factor
Title for this comment
Comment