Detailed view for Bm1_00885

Basic information

TDR Targets ID: 235169
Brugia malayi, Immunoglobulin I-set domain containing protein
Source Database / ID:  GenBank

pI: 4.7628 | Length (AA): 966 | MW (Da): 108084 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00041   Fibronectin type III domain
PF13882   Bravo-like intracellular region
PF13927   Immunoglobulin domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
15 603 4yh7 (A) 85 611 28.00 0 1 0.574331 1.72
65 151 2bk8 (A) 5 93 17.00 0 0.51 0.241162 -0.44
66 144 2lvc (A) 11 89 16.00 0 0.14 0.227881 -0.65
75 196 3p3y (A) 261 377 32.00 0.0041 0.37 0.169894 1.2
331 709 1fnf (A) 1205 1503 28.00 0.14 1 0.34794 0.81
362 475 1x5h (A) 13 122 25.00 0 0.82 0.462112 -1.15
366 471 2e3v (A) 9 110 16.00 0 0.82 0.382831 -1.58
403 467 5j7k (A) 31 93 44.00 0.73 0.85 0.416888 -0.48
903 966 3sxs (A) 436 501 6.00 0.46 0 0.0848526 -0.49

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128647)

Species Accession Gene Product
Brugia malayi Bm1_39630   Immunoglobulin I-set domain containing protein
Brugia malayi Bm1_00885   Immunoglobulin I-set domain containing protein
Caenorhabditis elegans CELE_Y54G2A.25   Protein LAD-2, isoform C
Caenorhabditis elegans CELE_C18F3.2   Protein SAX-7, isoform C
Drosophila melanogaster Dmel_CG1634   Neuroglian
Echinococcus granulosus EgrG_000787300   neuroglian
Echinococcus granulosus EgrG_000240400   neuroglian
Echinococcus multilocularis EmuJ_000787300   neuroglian
Echinococcus multilocularis EmuJ_000240400   neuroglian
Homo sapiens ENSG00000091129   neuronal cell adhesion molecule
Homo sapiens ENSG00000163531   neurofascin
Homo sapiens ENSG00000134121   cell adhesion molecule L1-like
Homo sapiens ENSG00000198910   L1 cell adhesion molecule
Loa Loa (eye worm) LOAG_08396   hypothetical protein
Loa Loa (eye worm) LOAG_05936   hypothetical protein
Loa Loa (eye worm) LOAG_09334   LAD-2 short isoform
Loa Loa (eye worm) LOAG_14533   hypothetical protein
Mus musculus ENSMUSG00000030077   cell adhesion molecule with homology to L1CAM
Mus musculus ENSMUSG00000020598   neuronal cell adhesion molecule
Mus musculus ENSMUSG00000026442   neurofascin
Mus musculus 102641975   neuronal cell adhesion molecule-like
Mus musculus ENSMUSG00000031391   L1 cell adhesion molecule
Onchocerca volvulus OVOC3933  
Schistosoma japonicum Sjp_0131490   Neural cell adhesion molecule L1-like protein precursor, putative
Schistosoma japonicum Sjp_0131060   Neurofascin precursor, putative
Schmidtea mediterranea mk4.007418.03  
Schmidtea mediterranea mk4.023884.00  
Schmidtea mediterranea mk4.000021.10   Neuroglian

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0237 0.3038 0.4606
0.045 0.3045 0.3003
0.0178 0.5983 0.5
0.0334 0.4633 0.6876
0.0016 1 1
0.0129 0.3276 0.8182
0.0324 0.4032 0.5694
0.045 0.3045 0.3003
0.0236 0.2618 0.326
0.00858882 0.288628 0.23214
0.045 0.3045 0.3003
0.0084 0.6788 1
0.0306 0.5177 0.6775
0.0328 0.5101 0.6709
0.0331 0.5087 0.6644
0.0414 0.6115 1
0.0313 0.5953 1
0.0351 0.6072 1
0.0164 0.7647 0.7789
0.0089 0.442 0.3902
0.0271 0.3613 1
0.0048 0.4176 0.4167
0.0336 0.3462 1
0.0089 0.4623 0.4623
0.0216 0.706 1
0.0219 0.4579 0.6159
0.0251 0.7407 1
0.0334 0.4633 0.6876
0.0204 0.2891 0.326
0.021 0.4799 0.6436
0.021 0.4799 0.6436
0.008 0.4641 0
0.0471 0.341 1
0.036 0.4119 0.6424
0.045 0.3045 0.3003
0.0274 0.267 0.326
0.02 0.7068 1
0.0223 0.4639 0
0.0009 0.5 0.5
0.0178 0.5983 0.5
0.0184 0.706 1
0.045 0.3045 0.3003
0.0212 0.2754 0.3198
0.036 0.4119 0.6424
0.00858882 0.288628 0.23214
0.0461 0.2819 0.999
0.0378 0.586 1
0.0223 0.4639 0
0.0331 0.4032 0.5694
0.0362 0.2642 0.326
0.0343 0.706 1
0.0017 0.252 0.326
0.0461 0.2819 0.999
0.0104 0.8804 0.8804
0.045 0.3045 0.3003
0.0461 0.2819 0.999
0.0081 0.2507 0.2859
0.0338 0.7566 1
0.0084 0.6788 1
0.017 0.2614 1
0.0312 0.5397 1
0.0251 0.7407 1
0.0039 0.3299 0.4024
0.0271 0.2673 0.326
0.0302 0.2891 0.326
0.0343 0.706 1
0.0194 0.3524 0.4948
0.0207 0.4541 0.6008
0.0116 0.6967 0.9164
0.00858882 0.288628 0.23214
0.011 0.4641 0.6019
0.037 0.706 1
0.0274 0.4685 0.6331
0.0414 0.6115 1
0.045 0.3045 0.3003
0.0448 0.7636 1
0.0111 0.334 0.3848
0.0403 0.706 1
0.0146 0.4032 0.5694
0.0034 0.2581 0.2581
0.0374 0.7576 1
0.043 0.5151 1
0.0266 0.2855 1
0.0155 0.3568 1
0.0274 0.267 0.326
0.0083 1 1
0.0272 0.706 1
0.0461 0.2819 0.999
0.0378 0.586 1
0.0471 0.341 1
0.036 0.4119 0.6424
0.0079 0.4609 0.5062
0.0374 0.7576 1
0.0219 0.4579 0.6159
0.0159 0.2996 0.2973
0.0181 0.2727 0.326
0.012 0.7362 0.9962
0.0193 0.4477 0.5933
0.0156 0.6042 1
0.036 0.4119 0.6424
0.0095 0.3502 0.5058
0.0132 0.2972 0.4456
0.0488 0.3798 1
0.022 0.257 0.5218
0.012 0.7362 0.9962
0.0098 0.2712 0.462
0.0048 0.432 0.432
0.022 0.257 0.5218
0.0081 0.2507 0.2859
0.0475 0.706 1
0.0156 0.6042 1
0.0255 0.706 1
0.036 0.4119 0.6424
0.0347 0.7081 0.8937
0.0114 0.6153 1
0.0306 0.4883 0.6513
0.045 0.3045 0.3003
0.0089 0.442 0.3902
0.0255 0.706 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Bm1_00885 (Brugia malayi), Immunoglobulin I-set domain containing protein
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