Detailed view for Bm1_52445

Basic information

TDR Targets ID: 235353
Brugia malayi, Alcohol dehydrogenase class III
Source Database / ID:  GenBank

pI: 7.2566 | Length (AA): 423 | MW (Da): 46465 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00107   Zinc-binding dehydrogenase
PF08240   Alcohol dehydrogenase GroES-like domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0051903   S-(hydroxymethyl)glutathione dehydrogenase activity  
GO:0016491   oxidoreductase activity  
GO:0008270   zinc ion binding  
GO:0005488   binding  
GO:0003824   catalytic activity  
GO:0055114   oxidation reduction  
GO:0008152   metabolic process  
GO:0006069   ethanol oxidation  

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127257)

Species Accession Gene Product
Arabidopsis thaliana AT1G77120   alcohol dehydrogenase 1
Arabidopsis thaliana AT5G43940   alcohol dehydrogenase class-3
Arabidopsis thaliana AT5G63620   GroES-like zinc-binding alcohol dehydrogenase family protein
Brugia malayi Bm1_52445   Alcohol dehydrogenase class III
Candida albicans CaO19.7600   similar to C termini of C.maltosa FDH1 and S. cerevisiae SFA1 (YDL168W) glutathione-dependent formaldehyde dehydrogenase, long-c
Caenorhabditis elegans CELE_H24K24.3   Protein H24K24.3, isoform B
Caenorhabditis elegans CELE_Y50D4C.2   Protein Y50D4C.2
Dictyostelium discoideum DDB_G0281865   alcohol dehydrogenase, class 3
Drosophila melanogaster Dmel_CG6598   Formaldehyde dehydrogenase
Escherichia coli b0356   alcohol dehydrogenase class III/glutathione-dependent formaldehyde dehydrogenase
Homo sapiens ENSG00000187758   alcohol dehydrogenase 1A (class I), alpha polypeptide
Homo sapiens ENSG00000196616   alcohol dehydrogenase 1B (class I), beta polypeptide
Homo sapiens ENSG00000197894   alcohol dehydrogenase 5 (class III), chi polypeptide
Homo sapiens ENSG00000248144   alcohol dehydrogenase 1C (class I), gamma polypeptide
Loa Loa (eye worm) LOAG_03095   alcohol dehydrogenase class III
Mycobacterium leprae ML1784   Probable S-nitrosomycothiol reductase MscR
Mus musculus 100417514   alcohol dehydrogenase 6B (class V)
Mus musculus ENSMUSG00000053054   alcohol dehydrogenase 6A (class V)
Mus musculus ENSMUSG00000074207   alcohol dehydrogenase 1 (class I)
Mus musculus ENSMUSG00000028138   alcohol dehydrogenase 5 (class III), chi polypeptide
Mycobacterium tuberculosis Rv3086   Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase)
Mycobacterium tuberculosis Rv0761c   Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB
Mycobacterium tuberculosis Rv0162c   Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1
Mycobacterium ulcerans MUL_4872   zinc-type alcohol dehydrogenase AdhD
Mycobacterium ulcerans MUL_1292   zinc-dependent alcohol dehydrogenase AdhE2
Mycobacterium ulcerans MUL_3861   zinc-containing alcohol dehydrogenase NAD dependent AdhB
Mycobacterium ulcerans MUL_0470   zinc-containing alcohol dehydrogenase NAD-dependent AdhB
Mycobacterium ulcerans MUL_4777   zinc-dependent alcohol dehydrogenase
Neospora caninum NCLIV_055560   alcohol dehydrogenase class III, putative
Oryza sativa 4344469   Os08g0109200
Oryza sativa 4350053   Os11g0210300
Oryza sativa 4331130   Os02g0815500
Oryza sativa 4350054   Os11g0210500
Onchocerca volvulus OVOC6614   Putative alcohol dehydrogenase
Saccharomyces cerevisiae YDL168W   bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase
Schistosoma japonicum Sjp_0102900   Alcohol dehydrogenase class-3, putative
Schistosoma japonicum Sjp_0101110   Alcohol dehydrogenase class-3, putative
Schistosoma japonicum Sjp_0313140   ko:K00001 alcohol dehydrogenase [EC1.1.1.1], putative
Schistosoma mansoni Smp_044440   alcohol dehydrogenase
Schmidtea mediterranea mk4.001010.01   Putative alcohol dehydrogenase
Toxoplasma gondii TGME49_311780   Zn-containing alcohol dehydrogenase

Essentiality

Bm1_52445 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu3139 Mycobacterium tuberculosis non-essential nmpdr
b0356 Escherichia coli non-essential goodall
TGME49_311780 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens alcohol dehydrogenase 1A (class I), alpha polypeptide Compounds References
Homo sapiens alcohol dehydrogenase 1B (class I), beta polypeptide Compounds References
Equus caballus Alcohol dehydrogenase Compounds References
Homo sapiens alcohol dehydrogenase 1C (class I), gamma polypeptide Compounds References
Homo sapiens alcohol dehydrogenase 5 (class III), chi polypeptide Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Sorbitol dehydrogenase 357 aa 25.6% 320 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0734 0.9048 1
0.1005 0.2836 0.2836
0.1212 0.647 1
0.0154 0.4414 1
0.0228 0.2642 0.4954
0.1212 0.647 1
0.0085 0.4513 1
0.023 0.2814 0.8769
0.023 0.2814 0.8769
0.0078 0.3151 0.6915
0.0164 0.7858 0.7858
0.0156 0.4777 0.4777
0.0365 0.4222 1
0.0376 0.4347 1
0.0235 0.5394 0.539
0.0365 0.46 0.8177
0.0228 0.3497 1
0.0088 0.5269 0.5269
0.1388 0.5248 1
0.0072 0.4026 1
0.0734 0.9048 1
0.0228 0.7436 1
0.1005 0.2836 0.2836
0.0143 0.6967 0.6967
0.023 0.2814 0.8769
0.1388 0.5248 1
0.1388 0.5248 1
0.023 0.2814 0.8769
0.0147 0.4528 1
0.0228 0.271 1
0.1388 0.5248 1
0.0682 0.5861 0.5856
0.1005 0.2836 0.2836
0.015 0.4669 1
0.1388 0.5248 1
0.1005 0.2836 0.2836
0.1005 0.2836 0.2836
0.0679 0.4112 0.895
0.1054 0.9092 1
0.067 0.3779 0.8748
0.023 0.2814 0.8769
0.1319 0.5007 1
0.0088 0.5216 0.266
0.1319 0.5007 1
0.0365 0.4615 1
0.0841 0.9538 1
0.0147 0.4528 1
0.1005 0.2836 0.2836
0.0222 0.6062 0.6062
0.1005 0.2836 0.2836
0.0156 0.4777 0.4777

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Bm1_52445 (Brugia malayi), Alcohol dehydrogenase class III
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