pI: 7.1824 |
Length (AA): 284 |
MW (Da): 30773 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
5 | 282 | 3u0b (A) | 178 | 447 | 26.00 | 0 | 1 | 1.20517 | -0.07 |
35 | 282 | 2jah (A) | 4 | 246 | 37.00 | 0 | 1 | 1.41054 | -1.28 |
38 | 69 | 4fn4 (A) | 8 | 39 | 47.00 | 0 | 0.85 | 0.582876 | 0.72 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127267)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_41060 | oxidoreductase |
Candida albicans | CaO19.4633 | similar to insect-type short-chain alcohol dehydrogenase |
Candida albicans | CaO19.12103 | similar to insect-type short-chain alcohol dehydrogenase |
Dictyostelium discoideum | DDB_G0282357 | 3-oxoacyl-[acyl-carrier protein] reductase |
Drosophila melanogaster | Dmel_CG3301 | CG3301 gene product from transcript CG3301-RB |
Drosophila melanogaster | Dmel_CG40486 | CG40486 gene product from transcript CG40486-RC |
Drosophila melanogaster | Dmel_CG9360 | CG9360 gene product from transcript CG9360-RA |
Drosophila melanogaster | Dmel_CG40485 | CG40485 gene product from transcript CG40485-RB |
Drosophila melanogaster | Dmel_CG1386 | CG1386 gene product from transcript CG1386-RA |
Escherichia coli | b1539 | NADP-dependent 3-hydroxy acid dehydrogenase |
Echinococcus granulosus | EgrG_000754200 | oxidoreductase |
Echinococcus multilocularis | EmuJ_000754200 | oxidoreductase |
Homo sapiens | ENSG00000278535 | dehydrogenase/reductase (SDR family) member 11 |
Loa Loa (eye worm) | LOAG_08687 | oxidoreductase |
Mus musculus | ENSMUSG00000034449 | dehydrogenase/reductase (SDR family) member 11 |
Mycobacterium tuberculosis | Rv0484c | Probable short-chain type oxidoreductase |
Mycobacterium ulcerans | MUL_0028 | short-chain dehydrogenase |
Mycobacterium ulcerans | MUL_4554 | short-chain type oxidoreductase |
Saccharomyces cerevisiae | YMR226C | oxidoreductase |
Schmidtea mediterranea | mk4.005957.00 | Dehydrogenase/reductase SDR family member 11 |
Schmidtea mediterranea | mk4.000223.14 | Dehydrogenase/reductase SDR family member 11 |
Schmidtea mediterranea | mk4.002331.09 | |
Schmidtea mediterranea | mk4.054278.00 | Dehydrogenase/reductase SDR family member 11 |
Schmidtea mediterranea | mk4.004675.05 | |
Trichomonas vaginalis | TVAG_446780 | short-chain dehydrogenase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu489 | Mycobacterium tuberculosis | non-essential | nmpdr |
b1539 | Escherichia coli | non-essential | goodall |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Macaca mulatta | Hydroxysteroid 11-beta dehydrogenase 1 | 140 aa | 30.1% | 143 aa | Compounds | References |