Detailed view for Bm1_34510

Basic information

TDR Targets ID: 235411
Brugia malayi, calpain D

Source Database / ID:  GenBank

pI: 7.4281 | Length (AA): 700 | MW (Da): 79016 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Pfam domains

PF00648   Calpain family cysteine protease

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0008270   zinc ion binding  
GO:0004198   calcium-dependent cysteine-type endopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129863)

Species Accession Gene Product
Brugia malayi Bm1_34510 this record   calpain D
Caenorhabditis elegans CELE_T11A5.6   Protein T11A5.6, isoform C
Caenorhabditis elegans CELE_W05G11.4   Protein W05G11.4
Drosophila melanogaster Dmel_CG1391   small optic lobes
Entamoeba histolytica EHI_045290   calpain family cysteine protease, putative
Homo sapiens ENSG00000103326   calpain 15
Leishmania braziliensis LbrM.25.1350   calpain family cysteine protease-like protein
Leishmania donovani LdBPK_251540.1   calpain family cysteine protease-like protein
Leishmania infantum LinJ.25.1540   calpain family cysteine protease-like protein
Leishmania major LmjF.25.1480   calpain family cysteine protease-like protein
Leishmania mexicana LmxM.25.1480   calpain family cysteine protease-like protein
Loa Loa (eye worm) LOAG_01157   calpain D
Mus musculus ENSMUSG00000037326   calpain 15
Schmidtea mediterranea mk4.005279.01  
Schmidtea mediterranea mk4.005279.00  
Schmidtea mediterranea mk4.027150.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Leishmania major calpain family cysteine protease-like protein Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0343 0.331 0.3332
0.0288 0.3263 0.8541
0.0278 0.3096 0.5406

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Bm1_34510 (Brugia malayi), calpain D
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