Detailed view for Bm1_42240

Basic information

TDR Targets ID: 235418
Brugia malayi, Uncoordinated protein 104
Source Database / ID:  GenBank

pI: 7.5242 | Length (AA): 865 | MW (Da): 99368 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00169   PH domain
PF12423   Kinesin protein 1B
PF12473   Kinesin protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0003777   microtubule motor activity  
GO:0007018   microtubule-based movement  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 86 5b64 (B) 705 795 18.00 0.015 0.23 0.125754 -0.1
693 787 5afr (A) 292 410 35.00 0.37 0.06 0.163627 1.02
755 847 2dhj (A) 9 113 25.00 0 0.94 0.299314 -0.64
757 847 2w2w (H) 8 109 17.00 0 0.44 0.237002 -0.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126833)

Species Accession Gene Product
Brugia malayi Bm1_02450   kinesin like protein KLP-4
Brugia malayi Bm1_42245   kinesin-related protein
Brugia malayi Bm1_42240   Uncoordinated protein 104
Brugia malayi Bm1_42250   Uncoordinated protein 104
Candida albicans CaO19.3667   kinesin motor domain protein
Candida albicans CaO19.11151   kinesin motor domain protein
Caenorhabditis elegans CELE_R144.1   Protein KLP-6
Caenorhabditis elegans CELE_C52E12.2   Protein UNC-104, isoform B
Caenorhabditis elegans CELE_F56E3.3   Protein KLP-4, isoform A
Dictyostelium discoideum DDB_G0290963   kinesin family member 1
Drosophila melanogaster Dmel_CG8566   unc-104 ortholog (C. elegans)
Drosophila melanogaster Dmel_CG8183   Kinesin heavy chain 73
Echinococcus granulosus EgrG_000732900   kinesin
Echinococcus granulosus EgrG_000626900   Kinesin motor region
Echinococcus granulosus EgrG_000518900   kinesin protein KIF1B
Echinococcus multilocularis EmuJ_000732900   kinesin
Echinococcus multilocularis EmuJ_000518900   kinesin protein KIF1B
Echinococcus multilocularis EmuJ_000626900   Kinesin, motor region
Giardia lamblia GL50803_112846   Kinesin-3
Giardia lamblia GL50803_6262   Kinesin-3
Giardia lamblia GL50803_102101   Kinesin-3
Homo sapiens ENSG00000137177   kinesin family member 13A
Homo sapiens ENSG00000197892   kinesin family member 13B
Homo sapiens ENSG00000054523   kinesin family member 1B
Homo sapiens ENSG00000130294   kinesin family member 1A
Homo sapiens ENSG00000129250   kinesin family member 1C
Leishmania braziliensis LbrM.20.3890   Unc104-like kinesin, putative
Leishmania infantum LinJ.34.4090   Unc104-like kinesin, putative
Leishmania major LmjF.34.4260   Unc104-like kinesin, putative
Leishmania mexicana LmxM.33.4260   Unc104-like kinesin, putative
Loa Loa (eye worm) LOAG_15064   hypothetical protein
Loa Loa (eye worm) LOAG_10299   hypothetical protein
Loa Loa (eye worm) LOAG_15935   hypothetical protein
Loa Loa (eye worm) LOAG_10397   KIF16B
Loa Loa (eye worm) LOAG_14247   hypothetical protein
Loa Loa (eye worm) LOAG_07928   Kif1c protein
Loa Loa (eye worm) LOAG_13846   hypothetical protein
Loa Loa (eye worm) LOAG_13824   hypothetical protein
Loa Loa (eye worm) LOAG_07927   uncoordinated protein 104
Mus musculus ENSMUSG00000014602   kinesin family member 1A
Mus musculus ENSMUSG00000063077   kinesin family member 1B
Mus musculus ENSMUSG00000020821   kinesin family member 1C
Mus musculus ENSMUSG00000021375   kinesin family member 13A
Mus musculus ENSMUSG00000087236   predicted gene 1305
Mus musculus ENSMUSG00000060012   kinesin family member 13B
Neospora caninum NCLIV_004960   kinesin motor domain cointaining protein, putative
Neospora caninum NCLIV_062040   kinesin, putative
Schistosoma japonicum Sjp_0009810   ko:K10392 kinesin family member 1/13/14, putative
Schistosoma japonicum Sjp_0015350   Kinesin-like protein KIF1A, putative
Schistosoma japonicum Sjp_0123640   Kinesin-like protein unc-104, putative
Schistosoma japonicum Sjp_0009820   Kinesin-like protein KIF1B, putative
Schistosoma mansoni Smp_159790   hypothetical protein
Schistosoma mansoni Smp_134330   hypothetical protein
Schmidtea mediterranea mk4.000503.08  
Schmidtea mediterranea mk4.010388.00  
Schmidtea mediterranea mk4.000503.11   Kinesin-73
Schmidtea mediterranea mk4.000503.13   Kinesin-73
Schmidtea mediterranea mk4.013742.00  
Schmidtea mediterranea mk4.002945.12   Kinesin-like protein unc-104
Schmidtea mediterranea mk4.003433.01   Kinesin-73
Schmidtea mediterranea mk4.003433.02   Kinesin-73
Schmidtea mediterranea mk4.000477.01  
Schmidtea mediterranea mk4.010653.00  
Schmidtea mediterranea mk4.002945.11   Kinesin-like protein unc-104
Schmidtea mediterranea mk4.002945.06   Kinesin-like protein unc-104
Schmidtea mediterranea mk4.013742.02   Kinesin-related
Schmidtea mediterranea mk4.003433.00  
Schmidtea mediterranea mk4.000477.02  
Schmidtea mediterranea mk4.002945.07   Kinesin-like protein unc-104
Schmidtea mediterranea mk4.000503.09  
Schmidtea mediterranea mk4.029123.00   Kinesin-like protein unc-104
Schmidtea mediterranea mk4.019823.00  
Schmidtea mediterranea mk4.002549.02  
Schmidtea mediterranea mk4.025365.00  
Schmidtea mediterranea mk4.019823.02  
Schmidtea mediterranea mk4.002945.04   Kinesin-like protein unc-104
Schmidtea mediterranea mk4.002549.01  
Trypanosoma congolense TcIL3000.11.2290   Unc104-like kinesin, putative
Trypanosoma cruzi TcCLB.510687.94   Unc104-like kinesin, putative
Trypanosoma cruzi TcCLB.510687.100   Unc104-like kinesin, putative
Toxoplasma gondii TGME49_221420   Chromosome-associated kinesin KLP1, putative
Toxoplasma gondii TGME49_218210   Chromosome-associated kinesin KLP1, putative

Essentiality

Bm1_42240 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_221420 Toxoplasma gondii Probably essential sidik
TGME49_218210 Toxoplasma gondii Probably essential sidik
TGME49_221420 Toxoplasma gondii Essentiality uncertain sidik
TGME49_218210 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_42240 (Brugia malayi), Uncoordinated protein 104
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