Detailed view for Bm1_00140

Basic information

TDR Targets ID: 235453
Brugia malayi, Cell division protein

Source Database / ID:  GenBank

pI: 7.9775 | Length (AA): 427 | MW (Da): 49594 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00735   Septin

Gene Ontology

Mouse over links to read term descriptions.
GO:0031105   septin complex  
GO:0005525   GTP binding  
GO:0005515   protein binding  
GO:0007049   cell cycle  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
29 312 2qag (B) 21 305 40.00 0 1 0.869105 0.63
39 309 4z54 (A) 15 290 48.00 0 1 1.35666 -1.53
45 313 5cyo (A) 21 293 47.00 0 1 1.34898 -1.7
46 310 3t5d (A) 30 295 59.00 0 1 1.24661 -0.97
327 394 4uos (A) 3 69 31.00 0.32 0.45 0.715251 -2.22

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein


No expression data available for this gene


Ortholog group members (OG5_129485)

Species Accession Gene Product
Brugia malayi Bm1_00140   Cell division protein
Candida albicans CaO19.8657   septin
Candida albicans CaO19.1055   Deduced CDC3 protein
Caenorhabditis elegans CELE_W09C5.2   Protein UNC-59
Drosophila melanogaster Dmel_CG8705   peanut
Echinococcus granulosus EgrG_000208600   septin 7
Echinococcus multilocularis EmuJ_000208600   septin 7
Homo sapiens ENSG00000122545   septin 7
Loa Loa (eye worm) LOAG_10166   hypothetical protein
Mus musculus ENSMUSG00000001833   septin 7
Saccharomyces cerevisiae YLR314C   septin CDC3
Schistosoma mansoni Smp_060070   septin
Schmidtea mediterranea mk4.008378.00   Septin-7
Schmidtea mediterranea mk4.011252.00  
Schmidtea mediterranea mk4.020797.00   Septin 4
Schmidtea mediterranea mk4.004210.00   Septin-7
Schmidtea mediterranea mk4.001328.06  


Bm1_00140 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_W09C5.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_W09C5.2 Caenorhabditis elegans larval arrest wormbase
CELE_W09C5.2 Caenorhabditis elegans larval lethal wormbase
CELE_W09C5.2 Caenorhabditis elegans sterile wormbase
YLR314C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site,, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model


Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Bm1_00140 (Brugia malayi), Cell division protein
Title for this comment