Detailed view for Bm1_07635

Basic information

TDR Targets ID: 235687
Brugia malayi, GM16138p
Source Database / ID:  GenBank

pI: 4.8178 | Length (AA): 98 | MW (Da): 11038 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0090305   GO:nucleic acid phosphodiester bond hydrolysis  

GO:0004521   endoribonuclease activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_134106)

Species Accession Gene Product
Brugia malayi Bm1_07635   GM16138p
Caenorhabditis elegans CELE_F49C12.12   Protein F49C12.12
Caenorhabditis elegans CELE_C46G7.1   Protein C46G7.1
Drosophila melanogaster Dmel_CG40127   CG40127 gene product from transcript CG40127-RB
Echinococcus granulosus EgrG_001096200   ribonuclease kappa
Echinococcus multilocularis EmuJ_001096200   ribonuclease kappa
Homo sapiens ENSG00000219200   ribonuclease, RNase K
Loa Loa (eye worm) LOAG_13418   hypothetical protein
Mus musculus ENSMUSG00000093989   ribonuclease, RNase K
Onchocerca volvulus OVOC2369  
Schistosoma japonicum Sjp_0057680   Conserved hypothetical protein
Schistosoma mansoni Smp_105100   ribonuclease

Essentiality

Bm1_07635 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F49C12.12 Caenorhabditis elegans embryonic lethal wormbase
CELE_F49C12.12 Caenorhabditis elegans larval arrest wormbase
CELE_F49C12.12 Caenorhabditis elegans larval lethal wormbase
CELE_F49C12.12 Caenorhabditis elegans slow growth wormbase
CELE_F49C12.12 Caenorhabditis elegans sterile wormbase
CELE_C46G7.1 Caenorhabditis elegans larval lethal wormbase
CELE_C46G7.1 Caenorhabditis elegans slow growth wormbase
CELE_C46G7.1 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_07635 (Brugia malayi), GM16138p
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