pI: 6.1666 |
Length (AA): 666 |
MW (Da): 78381 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
564 | 640 | 1ufm (A) | 294 | 370 | 23.00 | 0 | 0.42 | 0.49 | -1.78 |
43 | 117 | 1na3 (A) | 4 | 75 | 17.00 | 0.013 | 0.28 | 0.343213 | -0.96 |
71 | 634 | 3txn (A) | 38 | 390 | 32.00 | 0 | 1 | 0.304447 | 3.28 |
111 | 229 | 4yvo (A) | 202 | 312 | 16.00 | 0.16 | 0.81 | 0.358279 | -0.32 |
47 | 113 | 2xev (A) | 5 | 71 | 10.00 | 0.18 | 0.05 | 0.284679 | -1 |
71 | 625 | 3txn (A) | 38 | 390 | 32.00 | 0 | 1 | 0.361249 | 2.95 |
573 | 628 | 2mr3 (A) | 301 | 356 | 14.00 | 0.12 | 0.24 | 0.187936 | 0.39 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 24 hs. | Otto TD |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, early schizont, Oocyst, Ring. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | sporozoite, early ring, early trophozoite, late schizont, late trophozoite, Sporozoite, Female Gametocyte, Male Gametocyte. | PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | gametocyte. | PlasmoDB |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Ortholog group members (OG5_127922)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G29150 | 26S proteasome non-ATPase regulatory subunit 9 |
Babesia bovis | BBOV_III008580 | PCI domain containing protein |
Brugia malayi | Bm1_41190 | Proteasome regulatory particle, non-atpase-like protein 6 |
Candida albicans | CaO19.1299 | similar to S. cerevisiae RPN6 (YDL097C) subunit of the 19S regulatory particle of the 26S proteasome |
Candida albicans | CaO19.8879 | similar to S. cerevisiae RPN6 (YDL097C) subunit of the 19S regulatory particle of the 26S proteasome |
Caenorhabditis elegans | CELE_F57B9.10 | Protein RPN-6.1, isoform B |
Cryptosporidium hominis | Chro.60414 | 26S proteasome non-ATPase regulatory subunit |
Cryptosporidium parvum | cgd6_3590 | 26S proteasome regulatory subunit Rpn6-like; PINT domain containing protein |
Dictyostelium discoideum | DDB_G0281315 | 26S proteasome non-ATPase regulatory subunit 11 |
Drosophila melanogaster | Dmel_CG10149 | Regulatory particle non-ATPase 6 |
Echinococcus granulosus | EgrG_000736900 | 26S proteasome non ATPase regulatory subunit |
Entamoeba histolytica | EHI_182600 | proteasome regulatory subunit, putative |
Echinococcus multilocularis | EmuJ_000736900 | 26S proteasome non ATPase regulatory subunit |
Giardia lamblia | GL50803_16659 | Hypothetical protein |
Homo sapiens | ENSG00000108671 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 |
Leishmania braziliensis | LbrM.02.0400 | proteasome regulatory non-ATPase subunit 6, putative |
Leishmania donovani | LdBPK_020340.1 | proteasome regulatory non-ATPase subunit 6, putative |
Leishmania infantum | LinJ.02.0340 | proteasome regulatory non-ATPase subunit 6, putative |
Leishmania major | LmjF.02.0370 | proteasome regulatory non-ATPase subunit 6, putative |
Leishmania mexicana | LmxM.02.0370 | proteasome regulatory non-ATPase subunit 6, putative |
Loa Loa (eye worm) | LOAG_04911 | proteasome regulatory particle |
Mus musculus | ENSMUSG00000017428 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 |
Neospora caninum | NCLIV_045440 | proteasome PCI domain-containing protein, putative |
Oryza sativa | 4333303 | Os03g0576400 |
Oryza sativa | 4335951 | Os04g0444600 |
Plasmodium berghei | PBANKA_1039600 | 26S proteasome regulatory subunit RPN6, putative |
Plasmodium falciparum | PF3D7_1402300 | 26S proteasome regulatory subunit RPN6 |
Plasmodium knowlesi | PKNH_1355800 | 26S proteasome regulatory subunit RPN6, putative |
Plasmodium vivax | PVX_086315 | 26S proteasome regulatory subunit RPN6, putative |
Plasmodium yoelii | PY00119 | hypothetical protein |
Saccharomyces cerevisiae | YDL097C | proteasome regulatory particle lid subunit RPN6 |
Schistosoma japonicum | Sjp_0096060 | ko:K03036 26S proteasome regulatory subunit N6, putative |
Schistosoma mansoni | Smp_061650 | 26S proteasome subunit S9 |
Schmidtea mediterranea | mk4.001308.00 | 26S proteasome subunit S9, putative |
Trypanosoma brucei gambiense | Tbg.972.2.990 | proteasome regulatory non-ATPase subunit 6 |
Trypanosoma brucei | Tb927.2.2440 | proteasome regulatory non-ATPase subunit 6 |
Trypanosoma cruzi | TcCLB.508741.300 | proteasome regulatory non-ATPase subunit 6, putative |
Toxoplasma gondii | TGME49_227960 | PCI domain-containing protein |
Theileria parva | TP04_0762 | proteosome subunit, putative |
Trichomonas vaginalis | TVAG_388670 | 26S proteasome subunit S9, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.2.2440 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.2.2440 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.2.2440 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.2.2440 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F57B9.10 | Caenorhabditis elegans | adult lethal | wormbase |
CELE_F57B9.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F57B9.10 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F57B9.10 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F57B9.10 | Caenorhabditis elegans | sterile | wormbase |
YDL097C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_227960 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | Compounds | References |