Detailed view for Bm1_26215

Basic information

TDR Targets ID: 236017
Brugia malayi, Ubiquitin carboxyl-terminal hydrolase family protein
Source Database / ID:  GenBank

pI: 5.0419 | Length (AA): 2976 | MW (Da): 339661 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00443   Ubiquitin carboxyl-terminal hydrolase
PF00883   Cytosol aminopeptidase family, catalytic domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0036459   GO:thiol-dependent ubiquitinyl hydrolase activity  

GO:0016579   protein deubiquitination  
GO:0005737   cytoplasm  
GO:0005622   intracellular  
GO:0008235   metalloexopeptidase activity  
GO:0004221   ubiquitin thiolesterase activity  
GO:0004177   aminopeptidase activity  
GO:0030145   manganese ion binding  
GO:0006511   ubiquitin-dependent protein catabolic process  
GO:0006508   proteolysis  
GO:0019538   protein metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 329 4k6j (A) 696 1046 9.00 0 0.03 0.165071 -0.02
106 179 3pei (A) 240 305 44.00 0.97 0.4 0.0553656 0.67
187 1105 4c0o (A) 4 902 11.00 0 0.86 0.363004 0.46
1244 2039 1z3h (A) 44 868 11.00 0 0.97 0.326673 0.47
1488 2065 2qna (A) 126 689 14.00 0 1 0.21242 0.59
1856 2244 5j7t (A) 213 518 35.00 0 1 0.249212 0.49
1857 2247 1vjv (A) 109 497 23.00 0 1 0.262584 0.06

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130114)

Species Accession Gene Product
Brugia malayi Bm1_26215   Ubiquitin carboxyl-terminal hydrolase family protein
Caenorhabditis elegans CELE_T24B8.7   Protein T24B8.7, isoform A
Drosophila melanogaster Dmel_CG1945   fat facets
Echinococcus granulosus EgrG_000696800   ubiquitin carboxyl terminal hydrolase
Echinococcus multilocularis EmuJ_000696800   ubiquitin carboxyl terminal hydrolase
Homo sapiens ENSG00000162402   ubiquitin specific peptidase 24
Homo sapiens ENSG00000124486   ubiquitin specific peptidase 9, X-linked
Homo sapiens ENSG00000114374   ubiquitin specific peptidase 9, Y-linked
Loa Loa (eye worm) LOAG_14196   hypothetical protein
Loa Loa (eye worm) LOAG_03956   hypothetical protein
Loa Loa (eye worm) LOAG_14586   hypothetical protein
Loa Loa (eye worm) LOAG_04131   hypothetical protein
Loa Loa (eye worm) LOAG_14950   hypothetical protein
Loa Loa (eye worm) LOAG_15883   hypothetical protein
Mus musculus ENSMUSG00000069044   ubiquitin specific peptidase 9, Y chromosome
Mus musculus ENSMUSG00000028514   ubiquitin specific peptidase 24
Mus musculus ENSMUSG00000031010   ubiquitin specific peptidase 9, X chromosome
Schistosoma japonicum Sjp_0032150   ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative
Schistosoma japonicum Sjp_0032170   ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative
Schistosoma mansoni Smp_131570   ubiquitin-specific peptidase 9X (C19 family)
Schmidtea mediterranea mk4.000419.05  
Schmidtea mediterranea mk4.004531.00  
Schmidtea mediterranea mk4.001582.03   Ubiquitin carboxyl-terminal hydrolase 24
Schmidtea mediterranea mk4.001582.01  
Schmidtea mediterranea mk4.009389.00  
Schmidtea mediterranea mk4.004531.01   Probable ubiquitin carboxyl-terminal hydrolase FAF
Schmidtea mediterranea mk4.001582.05   Probable ubiquitin carboxyl-terminal hydrolase FAF-X
Schmidtea mediterranea mk4.003251.01  
Schmidtea mediterranea mk4.001516.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ubiquitin specific peptidase 9, X-linked Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 457 aa 24.9% 398 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0102 0.3296 1
0.0056 0.4536 0.4536
0.0108 0.2544 0.3361
0.0108 0.2544 0.3361
0.0003 0.5 0.5
0.0004 0.5 0.5
0.0108 0.2544 0.3361
0.0103 0.4899 0.4848
0.0055 0.3328 0.3115
0.0102 0.2798 0.2798
0.0108 0.2544 0.3361
0.011 0.9687 0.9676
0.0053 0.3328 0.3115
0.0101 0.3355 0.6754
0.0004 0.5 0.5
0.011 0.2574 0.2575
0.0004 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_26215 (Brugia malayi), Ubiquitin carboxyl-terminal hydrolase family protein
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