Detailed view for Bm1_54240

Basic information

TDR Targets ID: 236336
Brugia malayi, Endonuclease/Exonuclease/phosphatase family protein
Source Database / ID:  GenBank

pI: 8.284 | Length (AA): 391 | MW (Da): 44640 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03372   Endonuclease/Exonuclease/phosphatase family

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Sphingolipid metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 281 3g6s (A) 4 260 17.00 0 1 0.82984 0.13
5 279 1ako (A) 1 266 15.00 0 0.97 0.740725 0.14
189 231 2i13 (B) 117 174 37.00 0.12 0.19 0.517374 -0.27
298 347 3a1p (B) 14 63 32.00 0.79 0.23 0.406277 0.56

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130232)

Species Accession Gene Product
Brugia malayi Bm1_54240   Endonuclease/Exonuclease/phosphatase family protein
Candida albicans CaO19.6629   potential endonuclease/phosphatase similar to S. cerevisiae ISC1 (YER019W) phospholipase C/sphingomyelinase
Candida albicans CaO19.13950   potential endonuclease/phosphatase similar to S. cerevisiae ISC1 (YER019W) phospholipase C/sphingomyelinase
Caenorhabditis elegans CELE_T27F6.6   Protein T27F6.6
Drosophila melanogaster Dmel_CG12034   CG12034 gene product from transcript CG12034-RA
Echinococcus granulosus EgrG_001052200   expressed conserved protein
Echinococcus granulosus EgrG_000372200   neutral sphingomyelinase
Echinococcus granulosus EgrG_000705800   hypothetical protein
Echinococcus multilocularis EmuJ_000372200   neutral sphingomyelinase
Echinococcus multilocularis EmuJ_000705800   conserved hypothetical protein
Echinococcus multilocularis EmuJ_001052200   expressed conserved protein
Homo sapiens ENSG00000135587   sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
Loa Loa (eye worm) LOAG_05145   hypothetical protein
Mus musculus ENSMUSG00000019822   sphingomyelin phosphodiesterase 2, neutral
Onchocerca volvulus OVOC8931   Putative neutral sphingomyelinase
Saccharomyces cerevisiae YER019W   inositol phosphosphingolipid phospholipase
Schistosoma japonicum Sjp_0211770   ko:K01117 sphingomyelin phosphodiesterase [EC3.1.4.12], putative
Schistosoma japonicum Sjp_0312040   expressed protein
Schistosoma mansoni Smp_162880   neutral sphingomyelinase
Schmidtea mediterranea mk4.019670.01   Putative neutral sphingomyelinase
Schmidtea mediterranea mk4.000653.02   Sphingomyelin phosphodiesterase 2

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) Compounds References
Rattus norvegicus Neutral sphingomyelinase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1135 0.2633 1
0.0393 0.3934 1
0.0115 0.4359 0.4343
0.0257 0.3046 1
0.012 0.6433 0.6238
0.1112 0.759 1
0.0358 0.4376 0.7993
0.0144 0.3238 0.8386
0.012 0.6433 0.6238
0.0144 0.6273 0.6273
0.0291 0.3976 1
0.0291 0.3976 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_54240 (Brugia malayi), Endonuclease/Exonuclease/phosphatase family protein
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