Detailed view for Bm1_27855

Basic information

TDR Targets ID: 236921
Brugia malayi, Spectrin alpha chain
Source Database / ID:  GenBank

pI: 5.1263 | Length (AA): 2423 | MW (Da): 281193 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00018   SH3 domain
PF00435   Spectrin repeat
PF08726   Ca2+ insensitive EF hand
PF13499   EF-hand domain pair

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0005509   calcium ion binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
985 1046 1neg (A) 6 67 76.00 0 1 0.829888 -0.95
1089 1192 3uul (A) 314 418 30.00 0.15 1 0.565722 -1.86
1180 2284 5hdt (A) 29 1049 12.00 0 1 0.328346 0.87

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126924)

Species Accession Gene Product
Brugia malayi Bm1_55530   beta-G spectrin, identical
Brugia malayi Bm1_22625   probable spectrin beta chain
Brugia malayi Bm1_27855   Spectrin alpha chain
Brugia malayi Bm1_52790   beta-G spectrin
Caenorhabditis elegans CELE_R31.1   Protein SMA-1, isoform B
Caenorhabditis elegans CELE_K11C4.3   Protein UNC-70, isoform B
Caenorhabditis elegans CELE_K10B3.10   Protein SPC-1, isoform A
Drosophila melanogaster Dmel_CG5870   beta Spectrin
Drosophila melanogaster Dmel_CG12008   karst
Drosophila melanogaster Dmel_CG1977   alpha Spectrin
Echinococcus granulosus EgrG_000243500   spectrin beta chain
Echinococcus granulosus EgrG_000849000   spectrin beta chain
Echinococcus granulosus EgrG_000650120   spectrin beta chain, erythrocyte
Echinococcus granulosus EgrG_000486600   Spectrin alpha actinin
Echinococcus granulosus EgrG_000151600   Spectrin alpha actinin
Echinococcus multilocularis EmuJ_000849900   Spectrin beta chain brain 3
Echinococcus multilocularis EmuJ_000004400   Spectrin beta chain brain 3
Echinococcus multilocularis EmuJ_000243500  
Echinococcus multilocularis EmuJ_000486600   Spectrin alpha actinin
Echinococcus multilocularis EmuJ_000151600   Spectrin alpha actinin
Echinococcus multilocularis EmuJ_000849000   spectrin beta chain
Echinococcus multilocularis EmuJ_000139000   zinc finger, C2H2 type
Echinococcus multilocularis EmuJ_000023200   Spectrin alpha actinin
Echinococcus multilocularis EmuJ_000650100   Pleckstrin y
Echinococcus multilocularis EmuJ_000650120  
Homo sapiens ENSG00000197694   spectrin, alpha, non-erythrocytic 1
Homo sapiens ENSG00000137877   spectrin, beta, non-erythrocytic 5
Homo sapiens ENSG00000115306   spectrin, beta, non-erythrocytic 1
Homo sapiens ENSG00000070182   spectrin, beta, erythrocytic
Homo sapiens ENSG00000163554   spectrin, alpha, erythrocytic 1
Homo sapiens ENSG00000173898   spectrin, beta, non-erythrocytic 2
Homo sapiens ENSG00000160460   spectrin, beta, non-erythrocytic 4
Loa Loa (eye worm) LOAG_10744   hypothetical protein
Loa Loa (eye worm) LOAG_10975   hypothetical protein
Loa Loa (eye worm) LOAG_02130   hypothetical protein
Loa Loa (eye worm) LOAG_06581   Spna2 protein
Loa Loa (eye worm) LOAG_15931   hypothetical protein
Loa Loa (eye worm) LOAG_12941   hypothetical protein
Loa Loa (eye worm) LOAG_10976   hypothetical protein
Loa Loa (eye worm) LOAG_05013   hypothetical protein
Loa Loa (eye worm) LOAG_04011   hypothetical protein
Mus musculus ENSMUSG00000067889   spectrin beta, non-erythrocytic 2
Mus musculus ENSMUSG00000020315   spectrin beta, non-erythrocytic 1
Mus musculus ENSMUSG00000057738   spectrin alpha, non-erythrocytic 1
Mus musculus ENSMUSG00000011751   spectrin beta, non-erythrocytic 4
Mus musculus 640524   spectrin beta, non-erythrocytic 5
Mus musculus ENSMUSG00000021061   spectrin beta, erythrocytic
Mus musculus ENSMUSG00000026532   spectrin alpha, erythrocytic 1
Schistosoma japonicum Sjp_0086140   Spectrin beta chain, erythrocyte, putative
Schistosoma japonicum Sjp_0091570   Spectrin beta chain, putative
Schistosoma japonicum Sjp_0314410   Spectrin beta chain, putative
Schistosoma japonicum Sjp_0119700   Spectrin beta chain, putative
Schistosoma japonicum Sjp_0302210   IPR003604,Zinc finger, U1-type;IPR007087,Zinc finger, C2H2-type,domain-containing
Schistosoma japonicum Sjp_0119780   Spectrin beta chain, putative
Schistosoma japonicum Sjp_0017310   ko:K06115 spectrin beta, putative
Schistosoma japonicum Sjp_0038660   Conserved hypothetical protein
Schistosoma japonicum Sjp_0034150   ko:K06114 spectrin alpha, putative
Schistosoma japonicum Sjp_0091560   Spectrin beta chain, brain 1, putative
Schistosoma mansoni Smp_143470.1   Spectrin beta chain brain 3 (Spectrin non-erythroid beta chain 3) (Beta-IV spectrin)
Schistosoma mansoni Smp_128920   alpha-actinin
Schistosoma mansoni Smp_170310   hypothetical protein
Schistosoma mansoni Smp_128930   hypothetical protein
Schistosoma mansoni Smp_143470.2   Spectrin beta chain brain 3 (Spectrin non-erythroid beta chain 3) (Beta-IV spectrin)
Schmidtea mediterranea mk4.001226.00  
Schmidtea mediterranea mk4.007578.00   Spectrin beta chain
Schmidtea mediterranea mk4.012777.00   Spectrin beta chain, brain 4
Schmidtea mediterranea mk4.004981.04   Spectrin beta chain
Schmidtea mediterranea mk4.012174.02   Spectrin alpha chain
Schmidtea mediterranea mk4.019898.01  
Schmidtea mediterranea mk4.033946.00  
Schmidtea mediterranea mk4.003579.03  
Schmidtea mediterranea mk4.019898.00   Spectrin beta chain, non-erythrocytic 4
Schmidtea mediterranea mk4.001623.02  
Schmidtea mediterranea mk4.012174.00   Uncharacterized calcium-binding protein
Schmidtea mediterranea mk4.001226.02  
Schmidtea mediterranea mk4.004981.02  
Schmidtea mediterranea mk4.003579.00   Spectrin beta chain, non-erythrocytic 4
Schmidtea mediterranea mk4.009111.00   Spectrin beta chain, brain 4
Schmidtea mediterranea mk4.004981.03  
Schmidtea mediterranea mk4.009111.01   Spectrin alpha chain
Schmidtea mediterranea mk4.001226.01  
Schmidtea mediterranea mk4.005764.00  
Schmidtea mediterranea mk4.007578.01  
Schmidtea mediterranea mk4.005915.01   Spectrin beta chain
Schmidtea mediterranea mk4.001623.03   Spectrin beta chain, non-erythrocytic 4
Schmidtea mediterranea mk4.005764.01   Spectrin beta chain
Schmidtea mediterranea mk4.003579.01   Spectrin beta chain
Schmidtea mediterranea mk4.012174.01   Spectrin alpha chain
Schmidtea mediterranea mk4.003768.00   Spectrin beta chain
Trichomonas vaginalis TVAG_247460   beta chain spectrin, putative
Trichomonas vaginalis TVAG_247470   hypothetical protein

Essentiality

Bm1_27855 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_R31.1 Caenorhabditis elegans slow growth wormbase
CELE_K10B3.10 Caenorhabditis elegans embryonic lethal wormbase
CELE_K10B3.10 Caenorhabditis elegans larval arrest wormbase
CELE_K10B3.10 Caenorhabditis elegans larval lethal wormbase
CELE_K11C4.3 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Calmodulin 149 aa 28.6% 154 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0322685 0.273741 0.262341
0.0282 0.283 0.4203
0.0068 0.2794 0.2794
0.0137 0.2846 0.2741
0.0039 0.2713 0.2713
0.0282 0.283 0.4203
0.0378 0.315 0.3101
0.0048 0.281 0.281
0.0075 0.2576 0.0875
0.00394418 0.278418 0.262031
0.0039 0.2713 0.2713
0.0029 0.4037 0.4037
0.0027 0.3179 0.2816
0.0027 0.3179 0.2816
0.0351989 0.270507 0.26116
0.0029 0.4037 0.4037
0.0061 1 1
0.0048 0.3625 0.3625
0.0064 0.3347 0.3362
0.0137 0.3036 0.3036
0.0059 0.3 0.3006
0.0065 0.3464 0.32
0.00394418 0.278418 0.262031
0.0065 0.3464 0.32
0.0336199 0.276589 0.265254

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Bm1_27855 (Brugia malayi), Spectrin alpha chain
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