Detailed view for Bm1_22785

Basic information

TDR Targets ID: 237048
Brugia malayi, Protein kinase domain containing protein
Source Database / ID:  GenBank

pI: 7.5282 | Length (AA): 1265 | MW (Da): 143532 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0005488   binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

Regulation of autophagy (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129368)

Species Accession Gene Product
Arabidopsis thaliana AT4G29380   phosphoinositide-3-kinase, regulatory subunit 4, p150
Brugia malayi Bm1_22785   Protein kinase domain containing protein
Candida albicans CaO19.7773   similar to S. cerevisiae VPS15 (YBR097W)
Candida albicans CaO19.7776   similar to N terminal half of VPS15 protein kinase involved in vacuolar protein sorting
Candida albicans CaO19.7775   similar to S. cerevisiae VPS15 (YBR097W)
Candida albicans CaO19.130   similar to N terminal half of VPS15 protein kinase involved in vacuolar protein sorting
Candida albicans CaO19.129   similar to S. cerevisiae VPS15 (YBR097W)
Caenorhabditis elegans CELE_ZK930.1   Protein ZK930.1, isoform B
Dictyostelium discoideum DDB_G0282627   VPS15 family protein kinase
Drosophila melanogaster Dmel_CG9746   immune response deficient 1
Echinococcus granulosus EgrG_000725500   phosphoinositide 3 kinase regulatory subunit 4
Entamoeba histolytica EHI_044190   protein kinase with WD repeats
Echinococcus multilocularis EmuJ_000725500   phosphoinositide 3 kinase regulatory subunit 4
Homo sapiens ENSG00000196455   phosphoinositide-3-kinase, regulatory subunit 4
Loa Loa (eye worm) LOAG_03673   VPS15 protein kinase
Loa Loa (eye worm) LOAG_11033   hypothetical protein
Mus musculus ENSMUSG00000032571   phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150
Oryza sativa 4331010   Os02g0796700
Saccharomyces cerevisiae YBR097W   Vps15p
Schistosoma japonicum Sjp_0032570   Phosphoinositide 3-kinase regulatory subunit 4, putative
Schistosoma japonicum Sjp_0032530   ko:K08333 phosphoinositide-3-kinase, regulatory subunit 4, p150, putative
Schistosoma mansoni Smp_123610   serine/threonine protein kinase
Schmidtea mediterranea mk4.001936.06  
Schmidtea mediterranea mk4.001936.03   Phosphoinositide 3-kinase regulatory subunit 4
Schmidtea mediterranea mk4.001936.02   Serine/threonine kinase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens phosphoinositide-3-kinase, regulatory subunit 4 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Jak1 protein 210 aa 22.8% 193 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0033 1 1
0.0039 0.9485 1
0.0022 0.5 0.5
0.0036 0.5 0.5
0.0008 0.5 0.5
0.0081 1 1
0.0066 0.3101 0
0.0004 0.5 0.5
0.0081 0.5 0.5
0.0059 1 1
0.0042 0.5 0.5
0.0039 0.5 0.5
0.0067 0.5 0.5
0.0012 0.5 0.5
0.0027 1 1
0.0069 0.3067 0.9179
0.0032 0.5 0.5
0.0026 0.5 0.5
0.0091 1 1
0.0092 1 1
0.0007 0.5 0.5
0.0003 0.5 0.5
0.0061 0.6883 0.6808
0.0063 0.7244 0
0.0039 0.5 0.5
0.0062 0.6935 0.7231
0.0093 0.8828 0
0.0029 0.5 0.5
0.0018 0.5 0.5
0.0037 1 0.5
0.0023 0.5 0.5
0.0011 1 1
0.0007 0.5 0.5
0.0012 0.5 0.5
0.0059 1 1
0.0064 0.3377 0.3377
0.0007 0.5 0.5
0.0033 0.5 0.5
0.0032 0.5 0.5
0.0059 1 1
0.0016 0.5 0.5
0.0098 0.3242 0.2614
0.0012 0.5 0.5
0.0016 0.5 0.5
0.0063 1 1
0.0056 1 1
0.0088 0.4477 0.4477

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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User comments

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Gene identifier Bm1_22785 (Brugia malayi), Protein kinase domain containing protein
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