pI: 11.119 |
Length (AA): 108 |
MW (Da): 12043 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 104 | 4bxo (B) | 117 | 214 | 26.00 | 0.0000013 | 0.78 | 1.17924 | -0.29 |
46 | 107 | 2a1j (B) | 234 | 295 | 37.00 | 0.000000032 | 1 | 1.14367 | -1.06 |
50 | 107 | 1x2i (A) | 12 | 69 | 21.00 | 0 | 0.73 | 0.871137 | -0.66 |
65 | 108 | 2kkp (A) | 41 | 89 | 43.00 | 0.58 | 0.59 | 0.773007 | 0.07 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128697)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G05210 | DNA excision repair protein ERCC-1 |
Babesia bovis | BBOV_III011710 | hypothetical protein |
Brugia malayi | Bm1_36110 | Helix-hairpin-helix motif family protein |
Candida albicans | CaO19.2469 | similar to ERCC1, known complex with ERCC4 protein |
Candida albicans | CaO19.10006 | similar to ERCC1, known complex with ERCC4 protein |
Caenorhabditis elegans | CELE_F10G8.7 | Protein ERCC-1 |
Cryptosporidium hominis | Chro.60302 | excision repair cross-complementing rodent repair deficiency,complementation group 1 |
Cryptosporidium parvum | cgd6_2610 | ERCC1 excision repair 1; C-terminal HhH domain |
Dictyostelium discoideum | DDB_G0267682 | DNA excision repair protein 1 |
Drosophila melanogaster | Dmel_CG10215 | CG10215 gene product from transcript CG10215-RA |
Echinococcus granulosus | EgrG_000614500 | DNA excision repair protein ERCC 1 |
Entamoeba histolytica | EHI_126160 | DNA excision repair protein, putative |
Echinococcus multilocularis | EmuJ_000614500 | DNA excision repair protein ERCC 1 |
Homo sapiens | ENSG00000012061 | excision repair cross-complementation group 1 |
Loa Loa (eye worm) | LOAG_05710 | helix-hairpin-helix domain-containing protein family protein |
Mus musculus | ENSMUSG00000003549 | excision repair cross-complementing rodent repair deficiency, complementation group 1 |
Neospora caninum | NCLIV_065530 | DNA repair protein rad10 domain-containing protein, putative |
Oryza sativa | 4349131 | Os10g0518900 |
Plasmodium berghei | PBANKA_0301200 | ERCC1 nucleotide excision repair protein, putative |
Plasmodium falciparum | PF3D7_0203300 | ERCC1 nucleotide excision repair protein, putative |
Plasmodium knowlesi | PKNH_0417800 | ERCC1 nucleotide excision repair protein, putative |
Plasmodium vivax | PVX_003600 | ERCC1 nucleotide excision repair protein, putative |
Plasmodium yoelii | PY06905 | DNA repair protein rad10, putative |
Saccharomyces cerevisiae | YML095C | Rad10p |
Schistosoma japonicum | Sjp_0202620 | DNA excision repair protein ERCC-1, putative |
Schistosoma mansoni | Smp_022470 | excision repair cross-complementing 1 ercc1 |
Toxoplasma gondii | TGME49_249330 | DNA repair protein rad10 subfamily protein |
Theileria parva | TP01_0997 | hypothetical protein |
Trichomonas vaginalis | TVAG_093320 | excision repair cross-complementing 1 ercc1, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_249330 | Toxoplasma gondii | Essentiality uncertain | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | excision repair cross-complementation group 1 | Compounds | References |