Detailed view for Bm1_19500

Basic information

TDR Targets ID: 237426
Brugia malayi, recombination factor GdRad54
Source Database / ID:  GenBank

pI: 8.1284 | Length (AA): 865 | MW (Da): 97729 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00176   SNF2 family N-terminal domain
PF00271   Helicase conserved C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004386   helicase activity  
GO:0003677   DNA binding  
GO:0003676   nucleic acid binding  

Metabolic Pathways

Homologous recombination (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
196 844 1z3i (X) 92 735 60.00 0 1 1.51779 -0.87

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127098)

Species Accession Gene Product
Arabidopsis thaliana AT3G19210   Rad54-like protein
Babesia bovis BBOV_IV009640   DNA repair and recombination protein RAD54-like, putative
Brugia malayi Bm1_13120   Type III restriction enzyme, res subunit family protein
Brugia malayi Bm1_19500   recombination factor GdRad54
Candida albicans CaO19.5004   similar to S. cerevisiae DNA-dependent ATPase required for x-ray damage repair and recombination
Candida albicans CaO19.12827   Putative helicase similar to RAD54
Candida albicans CaO19.5367   Putative helicase similar to RAD54
Candida albicans CaO19.12471   similar to S. cerevisiae DNA-dependent ATPase required for x-ray damage repair and recombination
Caenorhabditis elegans CELE_Y116A8C.13   Protein Y116A8C.13, isoform B
Caenorhabditis elegans CELE_W06D4.6   Protein RAD-54
Cryptosporidium hominis Chro.10140   DNA repair protein RAD54-like
Cryptosporidium parvum cgd1_1180   RAD54 like SWI/SNF2 ATpase
Dictyostelium discoideum DDB_G0285117   CHR group protein
Dictyostelium discoideum DDB_G0282997   CHR group protein
Drosophila melanogaster Dmel_CG3736   okra
Echinococcus granulosus EgrG_000609300   SPRY domain containing protein
Echinococcus granulosus EgrG_000446700   SPRY domain containing protein
Echinococcus granulosus EgrG_000375000   dna repair and recombination protein rad54
Echinococcus granulosus EgrG_000303900   DNA repair and recombination protein RAD54B
Echinococcus granulosus EgrG_000093900   SPRY domain containing protein
Entamoeba histolytica EHI_114930   DNA repair protein, putative
Entamoeba histolytica EHI_103840   DNA repair protein, putative
Echinococcus multilocularis EmuJ_000446700   SPRY domain containing protein
Echinococcus multilocularis EmuJ_000335300   dna repair and recombination protein rad54
Echinococcus multilocularis EmuJ_000303900  
Echinococcus multilocularis EmuJ_000375000   dna repair and recombination protein rad54
Echinococcus multilocularis EmuJ_000609300  
Echinococcus multilocularis EmuJ_000336000   dna repair and recombination protein rad54
Echinococcus multilocularis EmuJ_000093900   SPRY domain containing protein
Homo sapiens ENSG00000197275   RAD54 homolog B (S. cerevisiae)
Homo sapiens ENSG00000085999   RAD54-like (S. cerevisiae)
Leishmania braziliensis LbrM.24.0770   DNA repair and recombination protein RAD54, putative
Leishmania donovani LdBPK_240770.1   DNA repair and recombination protein RAD54, putative
Leishmania infantum LinJ.24.0770   DNA repair and recombination protein RAD54, putative
Leishmania major LmjF.24.0760   DNA repair and recombination protein RAD54, putative
Leishmania mexicana LmxM.24.0760   DNA repair and recombination protein RAD54, putative
Loa Loa (eye worm) LOAG_08903   hypothetical protein
Loa Loa (eye worm) LOAG_09350   type III restriction enzyme
Loa Loa (eye worm) LOAG_09349   hypothetical protein
Loa Loa (eye worm) LOAG_02898   hypothetical protein
Loa Loa (eye worm) LOAG_09351   hypothetical protein
Mus musculus ENSMUSG00000028702   RAD54 like (S. cerevisiae)
Mus musculus ENSMUSG00000078773   RAD54 homolog B (S. cerevisiae)
Neospora caninum NCLIV_032440   hypothetical protein
Oryza sativa 4330819   Os02g0762800
Plasmodium berghei PBANKA_1226800   DNA repair and recombination protein RAD54, putative
Plasmodium falciparum PF3D7_0803400   DNA repair and recombination protein RAD54, putative
Plasmodium knowlesi PKNH_0115500   DNA repair and recombination protein RAD54, putative
Plasmodium vivax PVX_093575   DNA repair protein RAD54, putative
Plasmodium yoelii PY00810   DNA repair protein RAD54-like-related
Saccharomyces cerevisiae YGL163C   DNA-dependent ATPase RAD54
Saccharomyces cerevisiae YBR073W   DNA-dependent ATPase RDH54
Schistosoma japonicum Sjp_0119580   DNA repair and recombination protein RAD54-like, putative
Schistosoma japonicum Sjp_0079550   DNA repair and recombination protein RAD54B, putative
Schistosoma japonicum Sjp_0031520   IPR000299,Band 4.1,domain-containing
Schistosoma japonicum Sjp_0031540   ko:K01529 RAD54L, GdRAD54; RAD54-like [EC:3.6.1.-], putative
Schistosoma japonicum Sjp_0080310   ATP-dependent RNA helicase DDX1, putative
Schistosoma mansoni Smp_194820   DNA repair and recombination protein rad54-related
Schistosoma mansoni Smp_026030   DNA repair and recombination protein rad54-related
Schmidtea mediterranea mk4.004644.01   DNA repair and recombination protein RAD54-like
Schmidtea mediterranea mk4.011618.00   Putative 4.1 G protein
Schmidtea mediterranea mk4.001926.03  
Schmidtea mediterranea mk4.004146.02   Putative 4.1 G protein
Schmidtea mediterranea mk4.031513.01  
Trypanosoma brucei gambiense Tbg972.11.6120   DNA repair and recombination protein RAD54, putative
Trypanosoma brucei Tb927.11.5430   DNA repair and recombination protein RAD54, putative
Trypanosoma congolense TcIL3000.11.5670   DNA repair and recombination protein RAD54, putative
Trypanosoma cruzi TcCLB.505183.40   DNA repair and recombination protein RAD54, putative
Trypanosoma cruzi TcCLB.508647.290   DNA repair and recombination protein RAD54, putative
Theileria parva TP01_0805   DNA repair protein rad54, putative

Essentiality

Bm1_19500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.3110 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.3110 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb11.02.3110 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb11.02.3110 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y116A8C.13 Caenorhabditis elegans embryonic lethal wormbase
PBANKA_1226800 Plasmodium berghei Slow plasmo
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens RAD54-like (S. cerevisiae) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

6 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Bm1_19500 (Brugia malayi), recombination factor GdRad54
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