Detailed view for Bm1_00165

Basic information

TDR Targets ID: 237440
Brugia malayi, KE2 family protein

Source Database / ID:  GenBank

pI: 7.287 | Length (AA): 454 | MW (Da): 51259 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01920   Prefoldin subunit

Gene Ontology

Mouse over links to read term descriptions.
GO:0016272   prefoldin complex  
GO:0051082   unfolded protein binding  
GO:0006457   protein folding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
76 145 3ndm (C) 356 402 30.00 0.077 0.03 -0.269315 1.97
334 449 4r61 (A) 20 140 28.00 0.14 0.05 0.450007 -0.16
342 453 2yfa (A) 140 251 9.00 0 0.05 0.504096 -2.14
342 449 4a55 (B) 458 559 21.00 0 0.33 0.455285 -0.67

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129530)

Species Accession Gene Product
Arabidopsis thaliana AT2G07340   prefoldin 1
Brugia malayi Bm1_13160   hypothetical protein
Brugia malayi Bm1_00165   KE2 family protein
Brugia malayi Bm1_00435   hypothetical protein
Candida albicans CaO19.3687   similar to prefoldin subunit 1 chaperone component
Candida albicans CaO19.11171   similar to prefoldin subunit 1 chaperone component
Caenorhabditis elegans CELE_C08F8.13   Protein PFD-1, isoform B
Caenorhabditis elegans CELE_C08F8.1   Protein PFD-1, isoform A
Dictyostelium discoideum DDB_G0287827   prefoldin beta-like domain containing protein
Drosophila melanogaster Dmel_CG13993   CG13993 gene product from transcript CG13993-RA
Homo sapiens ENSG00000113068   prefoldin subunit 1
Loa Loa (eye worm) LOAG_00479   hypothetical protein
Loa Loa (eye worm) LOAG_00478   hypothetical protein
Mus musculus ENSMUSG00000024346   prefoldin 1
Oryza sativa 4329310   Os02g0462900
Onchocerca volvulus OVOC398  
Saccharomyces cerevisiae YJL179W   Pfd1p
Schistosoma japonicum Sjp_0058260   IPR002777,Prefoldin beta-like;IPR009053,Prefoldin,domain-containing
Schistosoma mansoni Smp_009390.1   prefoldin subunit
Schistosoma mansoni Smp_009390.2   prefoldin subunit
Schmidtea mediterranea mk4.002678.00  

Essentiality

Bm1_00165 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C08F8.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_C08F8.1 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_00165 (Brugia malayi), KE2 family protein
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