Detailed view for Bm1_37565

Basic information

TDR Targets ID: 237539
Brugia malayi, Zn-finger in Ran binding protein and others containing protein
Source Database / ID:  GenBank

pI: 5.9193 | Length (AA): 729 | MW (Da): 82018 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00641   Zn-finger in Ran binding protein and others
PF02338   OTU-like cysteine protease

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0008270   zinc ion binding  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
109 140 3a9j (C) 662 693 31.00 0 0.32 0.422896 -0.72
109 138 1nj3 (A) 1 30 40.00 0.0099 0.48 0.469752 0.14
109 139 2k1p (A) 63 93 39.00 0 0.59 0.488524 -0.32
213 667 3zrh (A) 250 689 24.00 0 1 0.759343 0.28
421 591 3zje (A) 93 282 36.00 0.00000000059 1 0.477168 -0.28
421 587 5dod (F) 93 288 44.00 0.00000082 1 0.247681 0.56

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133625)

Species Accession Gene Product
Brugia malayi Bm1_37565   Zn-finger in Ran binding protein and others containing protein
Drosophila melanogaster Dmel_CG9448   trabid
Echinococcus granulosus EgrG_001071800   Zinc finger RanBP2 type
Echinococcus multilocularis EmuJ_001071800   Zinc finger, RanBP2 type
Homo sapiens ENSG00000019995   zinc finger, RAN-binding domain containing 1
Loa Loa (eye worm) LOAG_06865   Zn-finger in Ran binding protein
Loa Loa (eye worm) LOAG_05269   hypothetical protein
Mus musculus ENSMUSG00000030967   zinc finger, RAN-binding domain containing 1
Onchocerca volvulus OVOC4380   Ubiquitin thioesterase ZRANB1 homolog
Schistosoma japonicum Sjp_0314080   Conserved hypothetical protein
Schistosoma japonicum Sjp_0026540   Zinc finger Ran-binding domain-containing protein 1, putative
Schistosoma mansoni Smp_052350   TRABID protein (C64 family)
Schmidtea mediterranea mk4.004605.00   Ubiquitin thioesterase ZRANB1
Schmidtea mediterranea mk4.042926.00   Ubiquitin thioesterase ZRANB1
Schmidtea mediterranea mk4.011133.00   Ubiquitin thioesterase ZRANB1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0414 0.3472 0.3443
0.0219 0.2903 0.2903
0.0219 0.2903 0.2903
0.0096 0.336 0.3348
0.0138 0.3349 0.3294
0.0037 0.2654 0.2654
0.0209 0.3348 0.3256
0.0492 0.3407 0.336
0.0306 0.2511 0.3487
0.0261 0.3061 0.3061
0.0456 0.3409 0.3409
0.0247 0.2531 0.159
0.0128 0.3018 0.3018
0.0285 0.3113 0.3113
0.0422 0.2829 0.3479
0.0353 0.3507 0.3507
0.0133 0.3394 0
0.0498 0.3475 0.3475
0.0273 0.2964 0.3419
0.0123 0.3321 0.3321
0.0558 0.2532 0.3508
0.0254 0.2634 0.3399
0.0113 0.3091 0.316
0.0304 0.3509 0.3493
0.0307 0.3438 0.3438
0.0375 0.3505 0.3505
0.0331 0.3483 0.3453
0.0189 0.3334 0.1726
0.0395 0.3288 0.3264
0.0501 0.3438 0.3438
0.0579 0.3402 0.3402
0.0363 0.3359 0.3359
0.0155 0.2818 0.2818
0.0382 0.3427 0.3427
0.0336 0.3214 0.3214
0.0349 0.3468 0.3467
0.032 0.3438 0.3438
0.0274 0.296 0.3491
0.0319 0.3438 0.3438
0.0327 0.3261 0.3261
0.0469 0.3466 0.3466
0.041 0.3449 0.3449
0.0043 0.2685 0.2428
0.0247 0.2525 0.1577
0.0254 0.3313 0.3253
0.0034 0.2564 0.2564
0.0245 0.258 0.2572
0.032 0.3438 0.3438
0.0254 0.2634 0.3399
0.0258 0.3422 0.2992
0.017 0.2828 0.1095
0.0311 0.3264 0.3264
0.0102475 0.280464 0.23837
0.0313 0.285 0.3487
0.032 0.3438 0.3438
0.0036 0.2882 0.2568
0.0382 0.3427 0.3427
0.0219 0.2903 0.2903
0.0127 0.2969 0.2969
0.043 0.2664 0.2664
0.0532 0.2616 0
0.0521 0.34 0.3475
0.0203 0.2647 0.2609
0.0486 0.3438 0.3438
0.0304 0.2781 0.3476
0.0445 0.3486 0.3486
0.0129 0.2501 0.2501
0.0228 0.2543 0.3256
0.0516 0.3074 0.2267
0.0455 0.2669 0.3477
0.0311 0.3264 0.3264
0.038 0.3496 0.3496
0.0568 0.3496 0.3492
0.0288 0.352 0.352
0.0176 0.3337 0.3134
0.0273 0.2964 0.3419
0.0259 0.2982 0.342
0.0505 0.3488 0.3488
0.0142 0.3105 0.3105
0.033 0.3178 0.3156
0.0037 0.2654 0.2654
0.0123 0.293 0.293
0.0354 0.345 0.345
0.0313 0.3521 0.3495
0.0058 0.3143 0.3143
0.0492 0.3407 0.336
0.0323 0.3234 0.3481
0.0282 0.3434 0.3043
0.0401 0.2719 0.2719
0.0209 0.3348 0.3256
0.0351 0.3239 0.3239
0.0129 0.2501 0.2501
0.0311 0.3239 0.3239
0.0355 0.3433 0.3446
0.0029 0.2659 0.2221
0.0134 0.2618 0.1776
0.0339 0.3438 0.3438
0.0443 0.334 0.3336
0.0175 0.3372 0.3372
0.0138 0.3349 0.3294
0.008 0.3346 0.3346
0.0566 0.3159 0.3524
0.0133 0.3027 0.347
0.0422 0.2829 0.3479
0.0044 0.2766 0
0.0133 0.3027 0.347
0.0201 0.282 0.282
0.0022 0.2793 0.2793
0.0466 0.2741 0.2741
0.0544 0.3142 0.3032
0.0489 0.306 0.2128
0.0286 0.3142 0.3137
0.0207 0.2745 0.3143
0.0071 0.2779 0.3183
0.0111 0.2753 0.2718
0.0521 0.3438 0.3438
0.0138 0.3225 0.3225
0.0311 0.3115 0.2438
0.0228 0.3438 0.3438
0.0273 0.2964 0.3419
0.0219 0.2903 0.2903
0.0127 0.3436 0.3436
0.0152 0.2714 0.2714
0.0138 0.2666 0.1877
0.0416 0.3472 0.3472
0.0304 0.3509 0.3493
0.00665706 0.325018 0.311691
0.0534 0.3528 0.3528
0.0164 0.3128 0
0.0445 0.3486 0.3486
0.0023 0.3148 0.3148
0.0542 0.3099 0.234
0.0219 0.2903 0.2903
0.0129 0.3347 0.3347
0.012 0.3388 0.3352
0.0509 0.3457 0.3457
0.0476 0.3254 0.3254
0.0092 0.3412 0.3412
0.0219 0.2903 0.2903
0.049 0.3157 0.3157
0.0489 0.345 0.345
0.0505 0.3488 0.3488
0.0365 0.2915 0.2823
0.0469 0.3466 0.3466
0.0378 0.3425 0.3416
0.0448 0.3057 0.3049
0.0293 0.2686 0.3219
0.0459 0.3397 0.3397
0.0355 0.3433 0.3446
0.0394 0.2708 0.3448
0.0504 0.3096 0.3091
0.0232 0.3204 0.318
0.0185 0.3331 0.3331
0.0155 0.2763 0
0.0255 0.321 0.321
0.0261 0.3061 0.3061
0.0319 0.3391 0.3391
0.0534 0.3528 0.3528
0.0039 0.2989 0.273
0.012 0.3388 0.3352
0.0493 0.352 0.352
0.0521 0.34 0.3475
0.0273 0.2964 0.3419
0.0347 0.3424 0
0.0375 0.3505 0.3505
0.032 0.3438 0.3438
0.0076 0.2765 0.2765
0.0232 0.3204 0.318
0.0396 0.3457 0.3441
0.0443 0.334 0.3336
0.0493 0.352 0.352
0.0432 0.3438 0.3438
0.0247 0.3217 0.3217
0.0349 0.3246 0.3246
0.0043 0.3043 0.3043
0.0448 0.3057 0.3049
0.0467 0.305 0.3044
0.0493 0.352 0.352
0.0488 0.3448 0.3445
0.0343 0.3464 0.3453
0.0552 0.2987 0.3369
0.0056 0.2663 0.2663
0.054 0.3513 0.3476
0.0396 0.3457 0.3441
0.0117 0.2688 0.3394
0.0139 0.2681 0.1908
0.0238 0.3438 0.3438
0.0189 0.3334 0.1726
0.0445 0.3486 0.3486
0.0433 0.3324 0.3324
0.0538 0.269 0.269
0.0138 0.3225 0.3225
0.0527 0.3375 0.3375
0.0445 0.3486 0.3486
0.0556 0.3051 0.2706
0.0579 0.3385 0.3382
0.0538 0.269 0.269
0.0127 0.3436 0.3436
0.0179 0.2669 0.2665
0.041 0.3428 0.3428
0.0219 0.2903 0.2903
0.0538 0.269 0.269
0.0533 0.2913 0.1273
0.0451 0.324 0.3524
0.0036 0.2947 0.2666
0.0493 0.352 0.352
0.0368 0.2526 0.3413
0.0403 0.3537 0.3537
0.0354 0.345 0.345
0.0082 0.3426 0.3424
0.0048 0.2849 0.2849
0.0085 0.2648 0.256
0.0273 0.2964 0.3419
0.0129 0.2501 0.2501
0.0453 0.3529 0.351
0.0416 0.3472 0.3472
0.0347 0.3424 0
0.0219 0.2903 0.2903
0.0229 0.3337 0.345
0.0256 0.2563 0.1658
0.013 0.3049 0.319
0.0212 0.3148 0.3131
0.0521 0.3438 0.3438
0.054 0.2542 0
0.049 0.3157 0.3157
0.0337 0.3431 0.3431
0.0129 0.2612 0.1764
0.014 0.315 0.315
0.0024 0.2575 0.2087
0.0349 0.3246 0.3246
0.0361 0.3397 0.3397
0.0203 0.2977 0.2503
0.0063 0.3204 0.3204
0.0521 0.34 0.3475
0.0176 0.3438 0.3438
0.0296 0.3477 0.3477
0.0068 0.264 0.2998
0.0117 0.2688 0.3394
0.0131 0.2515 0
0.0214 0.2745 0.2745
0.0085 0.2846 0.3248
0.0418 0.3438 0.3438
0.0256 0.2563 0.1658
0.0343 0.3529 0.3529
0.0273 0.3426 0.3426
0.0209 0.3348 0.3256
0.0476 0.3438 0.3438
0.0285 0.3113 0.3113
0.0577 0.3352 0
0.0285 0.3113 0.3113
0.0093 0.2786 0.3452
0.0343 0.3464 0.3453
0.0037 0.2654 0.2654
0.0396 0.3457 0.3441
0.0349 0.3246 0.3246
0.016 0.3422 0.3422
0.0331 0.3483 0.3453
0.0368 0.2849 0
0.0492 0.35 0.35
0.0169 0.2843 0.2238
0.0273 0.2964 0.3419
0.0445 0.3486 0.3486
0.0396 0.3457 0.3441
0.0311 0.3115 0.2438
0.0259 0.3438 0.3438
0.0577 0.3257 0.3257
0.0273 0.3426 0.3426
0.049 0.3322 0.3057
0.0381 0.3359 0
0.0113 0.3091 0.316
0.0109 0.3407 0.3367
0.0307 0.3438 0.3438
0.0334 0.3513 0.3513
0.0455 0.2669 0.3477
0.0353 0.3484 0.3472

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Bm1_37565 (Brugia malayi), Zn-finger in Ran binding protein and others containing protein
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