Detailed view for Bm1_43015

Basic information

TDR Targets ID: 237747
Brugia malayi, TBC domain containing protein
Source Database / ID:  GenBank

pI: 5.7312 | Length (AA): 892 | MW (Da): 102612 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00169   PH domain
PF00566   Rab-GTPase-TBC domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0005097   Rab GTPase activator activity  
GO:0032313   regulation of Rab GTPase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
55 131 1v5u (A) 23 108 34.00 0.99 0.99 0.306723 0.14
57 134 2i5f (A) 257 347 35.00 0.0016 1 0.573844 -1.01
58 144 2d9x (A) 25 114 23.00 0 0.97 0.409834 -1.08
230 447 5cwm (A) 5 214 27.00 0.54 1 0.628795 -0.99
590 877 5tub (A) 318 626 16.00 0 1 0.45417 -0.4
598 870 3qye (A) 762 1034 25.00 0 1 0.609354 -1.18
602 859 1fkm (A) 250 600 22.00 0 1 0.402538 -0.72
603 878 3hzj (A) 513 772 28.00 0 1 0.618717 -1.18
607 825 5tub (A) 339 571 28.00 0.000038 0.93 0.435916 -0.12
607 885 4nc6 (A) 545 810 31.00 0 1 0.68018 -0.72

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127311)

Species Accession Gene Product
Arabidopsis thaliana AT3G07890   RabGAP/TBC domain-containing protein
Babesia bovis BBOV_IV005540   RabGAP/TBC domain-containing protein, putative
Brugia malayi Bm1_04155   TBC domain containing protein
Brugia malayi Bm1_43015   TBC domain containing protein
Candida albicans CaO19.8209   GTPase-activating protein for Sec4p
Candida albicans CaO19.578   GTPase-activating protein for Sec4p
Caenorhabditis elegans CELE_C04A2.1   Protein TBC-6
Caenorhabditis elegans CELE_ZK1248.10   Protein TBC-2
Caenorhabditis elegans CELE_C31E10.8   Protein TBC-19
Dictyostelium discoideum DDB_G0275345   hypothetical protein
Drosophila melanogaster Dmel_CG5916   CG5916 gene product from transcript CG5916-RB
Echinococcus granulosus EgrG_000523200   TBC1 domain family B
Echinococcus granulosus EgrG_001184100   growth hormone regulated TBC protein 1 A
Echinococcus granulosus EgrG_000523000   tbc tre 2:bub2:cdc16 domain family member
Echinococcus multilocularis EmuJ_000523000   tbc (tre 2:bub2:cdc16) domain family member
Echinococcus multilocularis EmuJ_000523200   TBC1 domain family B
Echinococcus multilocularis EmuJ_000567800   growth hormone regulated TBC protein
Echinococcus multilocularis EmuJ_001184100   growth hormone regulated TBC protein 1 A
Homo sapiens ENSG00000167202   TBC1 domain family, member 2B
Homo sapiens ENSG00000095383   TBC1 domain family, member 2
Homo sapiens ENSG00000139835   growth hormone regulated TBC protein 1
Leishmania braziliensis LbrM.29.1650   GTPase activator protein, putative
Leishmania mexicana LmxM.08_29.1560   GTPase activator protein, putative
Loa Loa (eye worm) LOAG_08500   hypothetical protein
Loa Loa (eye worm) LOAG_12385   hypothetical protein
Loa Loa (eye worm) LOAG_10835   TBC domain-containing protein
Loa Loa (eye worm) LOAG_13593   hypothetical protein
Loa Loa (eye worm) LOAG_14117   hypothetical protein
Loa Loa (eye worm) LOAG_14724   hypothetical protein
Mus musculus 102637899   predicted gene, 34595
Mus musculus ENSMUSG00000039813   TBC1 domain family, member 2
Mus musculus ENSMUSG00000038515   GH regulated TBC protein 1
Mus musculus ENSMUSG00000037410   TBC1 domain family, member 2B
Neospora caninum NCLIV_026190   Ankyrin repeat-containing protein, related
Oryza sativa 4345310   Os08g0337700
Onchocerca volvulus OVOC3300  
Onchocerca volvulus OVOC3297  
Plasmodium berghei PBANKA_0933400   GTPase-activating protein, putative
Plasmodium falciparum PF3D7_1114200   GTPase-activating protein, putative
Plasmodium knowlesi PKNH_0911800   GTPase-activating protein, putative
Plasmodium vivax PVX_091355   hypothetical protein, conserved
Plasmodium yoelii PY00727   hypothetical protein
Saccharomyces cerevisiae YNL293W   Msb3p
Saccharomyces cerevisiae YOL112W   Msb4p
Schistosoma japonicum Sjp_0061840   Growth hormone-regulated TBC protein 1, putative
Schistosoma japonicum Sjp_0305770   Growth hormone-regulated TBC protein 1, putative
Schistosoma japonicum Sjp_0044490   TBC1 domain family member 2B, putative
Schistosoma japonicum Sjp_0044510   hypothetical protein
Schistosoma japonicum Sjp_0044500   hypothetical protein
Schistosoma mansoni Smp_001420   gh regulated tbc protein-1
Schistosoma mansoni Smp_160470   hypothetical protein
Schmidtea mediterranea mk4.024480.00   Gh regulated tbc protein-1, putative
Schmidtea mediterranea mk4.004874.04   Gh regulated tbc protein-1, putative
Schmidtea mediterranea mk4.001566.00   Gh regulated tbc protein-1, putative
Trypanosoma cruzi TcCLB.506175.60   GTPase activator protein, putative
Trypanosoma cruzi TcCLB.509669.110   GTPase activator protein, putative
Toxoplasma gondii TGME49_261200   TBC domain-containing protein
Theileria parva TP01_0360   hypothetical protein, conserved
Trichomonas vaginalis TVAG_087290   gh regulated tbc protein-1, putative
Trichomonas vaginalis TVAG_265570   run and tbc1 domain containing 3, plant, putative

Essentiality

Bm1_43015 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_ZK1248.10 Caenorhabditis elegans embryonic lethal wormbase
CELE_ZK1248.10 Caenorhabditis elegans sterile wormbase
TGME49_261200 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Bm1_43015 (Brugia malayi), TBC domain containing protein
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