Detailed view for Bm1_16430

Basic information

TDR Targets ID: 237769
Brugia malayi, dehydrogenases, short chain protein 2
Source Database / ID:  GenBank

pI: 7.5507 | Length (AA): 216 | MW (Da): 24299 | Paralog Number: 5

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00106   short chain dehydrogenase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016491   oxidoreductase activity  
GO:0005488   binding  
GO:0003824   catalytic activity  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
19 215 4g5h (A) 0 167 26.00 0.071 1 1.03294 0.17
26 215 5ics (A) 3 182 24.00 0 1 1.20653 -0.79
33 93 5va8 (A) 8 68 16.00 0 0.61 0.571207 -1.2
33 203 1hxh (A) 7 168 30.00 0.000026 1 1.11117 -0.2
36 156 2pd6 (A) 15 137 38.00 0.00082 1 0.912685 -0.23

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127235)

Species Accession Gene Product
Babesia bovis BBOV_IV010140   hypothetical protein
Brugia malayi Bm1_14935   D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor
Brugia malayi Bm1_16425   oxidoreductase, short chain dehydrogenase/reductase family protein
Brugia malayi Bm1_16440   oxidoreductase, short chain dehydrogenase/reductase family protein
Brugia malayi Bm1_16435   oxidoreductase, short chain dehydrogenase/reductase family protein
Brugia malayi Bm1_16200   hypothetical protein
Brugia malayi Bm1_16430   dehydrogenases, short chain protein 2
Caenorhabditis elegans CELE_F35B12.2   Protein DHS-20
Caenorhabditis elegans CELE_C10F3.2   Protein DHS-16
Caenorhabditis elegans CELE_F55A12.4   Protein DHS-2, isoform B
Drosophila melanogaster Dmel_CG12068   shroud
Drosophila melanogaster Dmel_CG8888   CG8888 gene product from transcript CG8888-RA
Homo sapiens ENSG00000073737   dehydrogenase/reductase (SDR family) member 9
Homo sapiens ENSG00000161267   3-hydroxybutyrate dehydrogenase, type 1
Homo sapiens 8608   retinol dehydrogenase 16 (all-trans)
Homo sapiens ENSG00000170426   short chain dehydrogenase/reductase family 9C, member 7
Loa Loa (eye worm) LOAG_16139   hypothetical protein
Loa Loa (eye worm) LOAG_15298   oxidoreductase
Loa Loa (eye worm) LOAG_13416   hypothetical protein
Loa Loa (eye worm) LOAG_16277   hypothetical protein
Loa Loa (eye worm) LOAG_11782   hypothetical protein
Mus musculus ENSMUSG00000046598   3-hydroxybutyrate dehydrogenase, type 1
Mus musculus ENSMUSG00000074639   cDNA sequence BC089597
Mus musculus ENSMUSG00000054052   retinol dehydrogenase 19
Mus musculus ENSMUSG00000040127   4short chain dehydrogenase/reductase family 9C, member 7
Mus musculus ENSMUSG00000040134   retinol dehydrogenase 7
Mus musculus ENSMUSG00000069456   retinol dehydrogenase 16
Mus musculus 241452   dehydrogenase/reductase (SDR family) member 9
Mus musculus ENSMUSG00000056148   retinol dehydrogenase 9
Mus musculus ENSMUSG00000089789   retinol dehydrogenase 1 (all trans)
Mycobacterium ulcerans MUL_3865   dehydrogenase/decarboxylase protein
Mycobacterium ulcerans MUL_0057   short chain dehydrogenase
Neospora caninum NCLIV_008280   short chain dehydrogenase domain-containing protein, putative
Onchocerca volvulus OVOC2299  
Onchocerca volvulus OVOC2301  
Onchocerca volvulus OVOC2302  
Onchocerca volvulus OVOC2303  
Onchocerca volvulus OVOC2298  
Onchocerca volvulus OVOC1715  
Schmidtea mediterranea mk4.001226.05  
Schmidtea mediterranea mk4.001226.04  
Schmidtea mediterranea mk4.048279.00  
Schmidtea mediterranea mk4.001226.08  
Schmidtea mediterranea mk4.001226.07  
Toxoplasma gondii TGME49_253960   oxidoreductase, short chain dehydrogenase/reductase family protein
Theileria parva TP01_0657   3-oxoacyl-[acyl-carrier protein] reductase, putative

Essentiality

Bm1_16430 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_253960 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Dehydrogenase/reductase SDR family member 9 Compounds References
Homo sapiens dehydrogenase/reductase (SDR family) member 9 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Macaca mulatta Hydroxysteroid 11-beta dehydrogenase 1 140 aa 21.4% 145 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0021 0.3321 0.3321
0.0068 0.2585 0.4116
0.0171 0.4063 0.3122
0.0046 0.3082 0
0.0119 0.2746 1
0.008 0.5 0.5
0.0131 0.5 0.5
0.0097 0.4304 1
0.0408 0.5144 0.8021
0.0108 0.5 0.5
0.0408 0.5144 0.8021
0.0106 1 1
0.0171 0.4063 0.3122
0.0073 0.3141 1
0.0045 1 1
0.0004 0.5 0.5
0.0005 0.5 0.5
0.007 0.2916 0.4349
0.0196 0.8679 0.8679
0.0009 0.5 0.5
0.0054 0.3206 0
0.0066 0.3586 0.3586
0.0027 0.5 0.5
0.0004 0.5 0.5
0.0408 0.5144 0.8021
0.0053 1 1
0.0009 0.5 0.5
0.0009 0.5 0.5
0.0093 0.5 0.5
0.004 0.5 0.5
0.0009 0.7374 0.7374
0.0118 1 1
0.0073 0.2873 0.2873
0.0088 0.6544 0.6544
0.0097 1 1
0.0009 0.5 0.5
0.0196 0.8679 0.8679
0.0123 0.5 0.5
0.0106 1 1
0.0009 0.5 0.5
0.0088 1 1
0.007 1 1
0.0106 0.2872 0.4415
0.0222 0.5 0.5
0.0019 0.4322 1
0.0068 1 1
0.011 0.3568 0.3568
0.0027 0.5 0.5
0.0026 0.5 0.5
0.0113 1 1
0.0068 1 1
0.016 0.577 1
0.0073 0.3811 0.3811
0.0004 0.5 0.5
0.0084 0.4283 0.4283
0.0089 0.5 0.5
0.0053 1 1
0.0165 1 1
0.0085 1 1
0.0056 1 1
0.0058 0.3931 0.5176
0.0054 0.3206 0
0.0218 0.5 0.5
0.0073 0.4546 0.4546
0.0009 1 0.5
0.0073 0.3811 0.3811
0.016 0.577 1
0.0032 1 1
0.0082 1 1
0.0064 0.3508 0.3956
0.007 0.2916 0.4349
0.0004 0.5 0.5
0.0402 1 1
0.0013 1 1
0.007 0.2916 0.4349
0.0012 0.5 0.5
0.0196 0.8679 0.8679
0.0004 0.5 0.5
0.0009 0.5 0.5
0.0102 0.7451 1
0.0058 1 1
0.0157 0.5 0.5
0.0132 0.3658 0.3658
0.0046 0.3206 0
0.0071 0.3141 0.3141
0.0087 0.5 0.5
0.0056 0.875 0.875
0.0067 0.3468 0.3468
0.0009 0.5 0.5
0.0114 1 1
0.0089 0.5 0.5
0.0039 1 1
0.0057 0.284 0.2725
0.0021 0.5 0.5
0.0114 1 1
0.0016 0.5 0.5
0.0035 1 1
0.007 1 1
0.0076 1 1
0.0009 0.5 0.5
0.0004 0.5 0.5
0.0005 0.5 0.5
0.0004 0.5 0.5
0.0013 0.5 0.5
0.0162 1 1
0.007 1 1
0.0106 0.5 0.5
0.0021 0.3321 0.3321
0.0012 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Bm1_16430 (Brugia malayi), dehydrogenases, short chain protein 2
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