Detailed view for Bm1_19625

Basic information

TDR Targets ID: 238496
Brugia malayi, eukaryotic translation initiation factor 3 subunit 7, putative
Source Database / ID:  GenBank

pI: 9.4773 | Length (AA): 493 | MW (Da): 56319 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05091   Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005852   eukaryotic translation initiation factor 3 complex  
GO:0005737   cytoplasm  
GO:0003743   translation initiation factor activity  
GO:0006413   translational initiation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
32 93 1szi (A) 218 278 23.00 0 0.01 0.450661 -1.28
78 239 2epl (X) 351 518 31.00 0.095 0.81 0.5519 0.19
122 493 5k4b (A) 172 530 61.00 0 1 1.53316 -1.28

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128265)

Species Accession Gene Product
Arabidopsis thaliana AT4G20980   eukaryotic translation initiation factor 3 subunit 7
Arabidopsis thaliana AT5G44320   translation initiation factor eIF-3 subunit 7
Babesia bovis BBOV_III000500   eukaryotic translation initiation factor 3 subunit 7, putative
Brugia malayi Bm1_03660   translation initiation factor 3 subunit 7
Brugia malayi Bm1_00085   translation initiation factor 3 subunit 7
Brugia malayi Bm1_19625   eukaryotic translation initiation factor 3 subunit 7, putative
Caenorhabditis elegans CELE_R08D7.3   Protein EIF-3.D
Cryptosporidium hominis Chro.20034   eukaryotic translation initiation factor 3 subunit 7
Cryptosporidium parvum cgd2_270   translation initiation factor eIF-3 subunit 7
Dictyostelium discoideum DDB_G0274627   eIF-3 zeta
Drosophila melanogaster Dmel_CG4810   CG4810 gene product from transcript CG4810-RA
Drosophila melanogaster Dmel_CG10161   Eukaryotic initiation factor 3 p66 subunit
Echinococcus granulosus EgrG_001125000   eukaryotic translation initiation factor 3
Echinococcus multilocularis EmuJ_001125000   eukaryotic translation initiation factor 3
Homo sapiens ENSG00000100353   eukaryotic translation initiation factor 3, subunit D
Leishmania braziliensis LbrM.30.3030   eukaryotic translation initiation factor 3 subunit 7-like protein
Leishmania donovani LdBPK_303080.1   eukaryotic translation initiation factor 3 subunit d
Leishmania infantum LinJ.30.3080   eukaryotic translation initiation factor 3 subunit 7-like protein
Leishmania mexicana LmxM.29.3040   eukaryotic translation initiation factor 3 subunit 7-like protein
Loa Loa (eye worm) LOAG_03764   hypothetical protein
Mus musculus ENSMUSG00000016554   eukaryotic translation initiation factor 3, subunit D
Neospora caninum NCLIV_012130   Eukaryotic translation initiation factor 3 subunit 7-like protein, related
Oryza sativa 4339634   Os05g0566500
Plasmodium berghei PBANKA_1206100   eukaryotic translation initiation factor 3 subunit D, putative
Plasmodium falciparum PF3D7_1007900   eukaryotic translation initiation factor 3 subunit D, putative
Plasmodium knowlesi PKNH_0806900   eukaryotic translation initiation factor 3 subunit D, putative
Plasmodium vivax PVX_094590   eukaryotic translation initiation factor 3 subunit 7, putative
Plasmodium yoelii PY04269   eukaryotic translation initiation factor 3 subunit 7
Schistosoma japonicum Sjp_0300780   ko:K03251 translation initiation factor eIF-3 subunit 7, putative
Schistosoma mansoni Smp_136290   eukaryotictranslation initiation factor 3 subunit
Schmidtea mediterranea mk4.000946.00   Eukaryotic translation initiation factor 3 subunit D
Trypanosoma brucei gambiense Tbg972.6.4180   eukaryotic translation initiation factor 3 subunit 7-like protein, putative
Trypanosoma brucei Tb927.6.4370   eukaryotic translation initiation factor 3 subunit d
Trypanosoma congolense TcIL3000_6_3790   eukaryotic translation initiation factor 3 subunit d
Trypanosoma cruzi TcCLB.509065.160   eukaryotic translation initiation factor 3 subunit d
Trypanosoma cruzi TcCLB.506943.160   eukaryotic translation initiation factor 3 subunit 7
Toxoplasma gondii TGME49_317720   eukaryotic translation initiation factor 3 subunit 7, putative
Theileria parva TP03_0787   eukaryotic translation initiation factor 3 subunit 7, putative
Trichomonas vaginalis TVAG_062640   eukaryotic translation initiation factor 3 subunit, putative

Essentiality

Bm1_19625 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.4370 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.6.4370 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.6.4370 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.6.4370 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_R08D7.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_R08D7.3 Caenorhabditis elegans slow growth wormbase
CELE_R08D7.3 Caenorhabditis elegans sterile wormbase
PBANKA_1206100 Plasmodium berghei Essential plasmo
TGME49_317720 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_19625 (Brugia malayi), eukaryotic translation initiation factor 3 subunit 7, putative
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