Detailed view for Bm1_52540

Basic information

TDR Targets ID: 238727
Brugia malayi, Protein kinase domain containing protein
Source Database / ID:  GenBank

pI: 9.0162 | Length (AA): 522 | MW (Da): 58545 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004712   protein serine/threonine/tyrosine kinase activity  
GO:0051304   chromosome separation  
GO:0007093   mitotic cell cycle checkpoint  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0005524   ATP binding  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 195 4k6j (A) 673 876 9.00 0 0.08 0.520763 -0.89
102 462 3kvw (A) 0 463 22.00 0 1 0.641571 0.22
114 492 4wb7 (A) 24 383 22.00 0 1 0.869054 0.19
186 462 4js8 (A) 515 792 49.00 0 1 1.04365 -0.61
196 498 3c0g (B) 12 305 24.00 0 1 0.77846 -0.36
196 499 5dew (B) 270 538 34.00 0 1 0.711475 0.36

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129339)

Species Accession Gene Product
Arabidopsis thaliana AT1G77720   putative protein kinase 1
Brugia malayi Bm1_52540   Protein kinase domain containing protein
Candida albicans CaO19.7293   protein threonine/tyrosine kinase
Dictyostelium discoideum DDB_G0280995   TTK family protein kinase
Drosophila melanogaster Dmel_CG7643   altered disjunction
Echinococcus granulosus EgrG_000595100   dual specificity serine:threonine tyrosine
Echinococcus multilocularis EmuJ_000595100   dual specificity serine:threonine tyrosine
Giardia lamblia GL50803_4405   Kinase, TTK
Homo sapiens ENSG00000112742   TTK protein kinase
Loa Loa (eye worm) LOAG_00261   TTK protein kinase
Mus musculus ENSMUSG00000038379   Ttk protein kinase
Oryza sativa 4333851   Os03g0704400
Onchocerca volvulus OVOC6636   Dual specificity protein kinase TTK homolog
Saccharomyces cerevisiae YDL028C   Mps1p
Schistosoma japonicum Sjp_0015280   ko:K05501 TetR/AcrR family transcriptional regulator, putative
Schistosoma mansoni Smp_171610   dual specificity serine/threonine tyrosine kinase
Schmidtea mediterranea mk4.005475.01  
Schmidtea mediterranea mk4.000052.13  
Schmidtea mediterranea mk4.013149.00  
Trichomonas vaginalis TVAG_267290   CAMK family protein kinase
Trichomonas vaginalis TVAG_335520   CAMK family protein kinase

Essentiality

Bm1_52540 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
YDL028C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens TTK protein kinase Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 25.5% 306 aa Compounds References
Patiria pectinifera Cdc2 300 aa 25.8% 298 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 26.9% 301 aa Compounds References
Xenopus laevis Aurora kinase B-A 361 aa 23.5% 388 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 29.0% 276 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 24.0% 300 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 18.7% 193 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 25.5% 298 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0554 0.8948 1
0.0089 0.5773 0.5634
0.0658 0.8156 1
0.0699 0.391 0.391
0.0679 0.8564 1
0.0087 0.7795 0.7987
0.0222 0.3112 1
0.0007 0.5 0.5
0.0307 0.302 0.4413
0.0843 0.4987 0.6809
0.0998 0.4831 0.4831
0.0088 0.5642 0.5642
0.025 0.2991 0.2991
0.1684 0.6372 0.6371
0.0087 0.5162 0
0.0088 0.2559 0.2062
0.0398 0.6531 0.6531
0.007 0.7208 0.7208
0.6206 0.7273 1
0.0304 0.4017 1
0.0934 0.4462 0.4462
0.0699 0.391 0.391
0.0088 0.4609 0.4609
0.0397 0.2678 0.2678
0.0306 0.3007 0.3007
0.0033 1 1
0.0059 1 1
0.1568 0.549 1
0.0032 0.5 0.5
0.3388 0.3086 0.3084
0.0089 0.618 0.5995
0.0023 0.5 0.5
0.0149 0.4253 0.4253
0.0398 0.6531 0.6531
0.0093 0.8828 0
0.0152 0.5571 0.9823
0.0088 0.4609 0.4609
0.0142 0.4931 0.4931
0.0155 0.3698 0.8536
0.0332 0.7185 1
0.0022 0.5 0.5
0.0039 0.5 0.5
0.0247 0.3402 1
0.0583 0.745 1
0.0239 0.2925 1
0.0721 0.4716 1
0.2444 0.7455 0.7455
0.3388 0.3086 0.3084
0.0747 0.9532 1
0.0089 0.5773 0.5634
0.2559 0.7406 1
0.0985 0.5476 0.5473
0.0679 0.8564 1
0.2565 0.273 0.273
0.2201 0.8915 0.8914
0.0554 0.8948 1
0.0793 0.7444 0.7444
0.0298 0.3135 1
0.0431 0.3815 0.3682
0.6206 0.7273 1
0.1677 0.5718 0.5718
0.0087 0.378 0.3769
0.2444 0.7455 0.7455
0.0934 0.4462 0.4462
0.0297 0.4075 0.4074
0.1949 0.8005 0.7924
0.0312 0.2993 0.2993
0.0063 1 1
0.0586 0.2727 0.2727
0.6121 0.5285 0.5527
0.1078 0.2561 0.2421
0.0087 0.378 0.3769
0.0088 0.2559 0.2062
0.6121 0.5285 0.5527
0.0061 0.6883 0.6808
0.0081 1 1
0.2444 0.7455 0.7455
0.0842 0.6125 1
0.0071 0.3723 0.3723
0.2449 0.5345 0.5343
0.0012 0.5 0.5
0.0312 0.3099 0.3079
0.119 0.5284 0.5279
0.0012 0.5 0.5
0.0375 0.821 1
0.0039 0.5 0.5
0.0087 0.5162 0
0.2444 0.7455 0.7455
0.0799 0.8086 0.8086
0.0323 0.3061 0.3061
0.1837 0.7376 0.6644
0.0715 0.8549 1
0.0523 0.2675 1
0.0166 0.3371 0.3371
0.0059 1 1
0.0583654 0.836861 1
0.0004 0.5 0.5
0.0377 0.5773 0.5634
0.1689 0.7492 0.7002
0.0799 0.8086 0.8086
0.0087 0.5162 0
0.0066 0.3101 0
0.0395 0.5206 0.5206
0.0523 0.2675 1
0.0378 0.3774 0.682
0.2559 0.7406 1
0.5784 0.7206 1
0.0032 0.5 0.5
0.0622 0.2617 1
0.3798 0.4939 0.4938
0.2449 0.5345 0.5343
0.133 0.9837 0.9837
0.2444 0.7455 0.7455
0.215 0.9132 0.9128
0.0622 0.2617 1
0.0396 0.3628 0.3628
0.0011 1 1
0.119 0.5284 0.5279
0.0087 0.5162 0
0.0711 0.444 1
0.0067 0.5 0.5
0.0222 0.4435 0.4435
0.0709 0.5275 0.5275
0.0747 0.9532 1
0.0089 0.5772 0.5084
0.0387 0.5431 0.6213
0.0082 0.358 0.358
0.0223 0.3472 0.3472
0.0936 0.3933 0.4553
0.0088 0.931 0.9266
0.0324 0.3369 0.3369
0.6206 0.7273 1
0.0092 1 1
0.0016 0.5 0.5
0.05 0.5719 1
0.0142 0.5349 0.5155
0.0436 0.4424 1
0.6206 0.7273 1
0.0087 0.3809 1
0.3798 0.4939 0.4938
0.0151 0.4154 0.4133
0.0523 0.2675 1
0.0222 0.3112 1
0.00966485 0.424148 0.430857
0.0003 0.5 0.5
0.2444 0.7455 0.7455
0.0056 1 1
0.0016 0.5 0.5
0.0474 0.7778 1
0.0543 0.5881 1
0.0843 0.4987 0.6809
0.0607 0.4269 0.4269
0.1243 0.6685 1
0.6206 0.7273 1
0.1833 0.4638 0.4638
0.0239 0.2762 0.4028
0.0246 0.3614 0.3614
0.0597533 0.3231 0.303282
0.1529 0.4762 0.4561
0.0064 0.3377 0.3377
0.0033 0.5 0.5
0.2417 0.6829 1
0.2444 0.7455 0.7455
0.0063 0.7244 0
0.0319 0.3013 0.299
0.0679 0.8564 1
0.0843 0.4987 0.6809
0.2362 0.2698 0.2697
0.1949 0.8005 0.7924
0.0029 0.5 0.5
0.0515 0.4841 0.9254
0.009 0.2566 0.4924
0.0147 0.4988 0
0.0039 0.9485 1
0.0152 0.3696 0.3696
0.0316 0.4616 0.4616
0.0241 0.2718 1
0.0243 0.2667 0.847
0.2065 0.8021 0.8016
0.0069 0.3067 0.9179
0.0842 0.6125 1
0.0635 0.7592 1
0.2417 0.6829 1
0.0156 0.8935 1
0.0089 0.3511 0.54
0.0151 0.2537 0.6581
0.0747 0.9532 1
0.0515 0.4841 0.9254
0.2444 0.7455 0.7455
0.0222 0.4435 0.4435
0.0534 0.7032 0.7032
0.0027 1 1
0.0834 0.8511 1
0.0088 0.3059 0.3427
0.0543 0.5881 1
0.0081 0.5 0.5
0.0567552 0.296973 0.381178
0.0242 0.3949 0.3949
0.2444 0.7455 0.7455
0.0397 0.3034 1
0.0699 0.391 0.391
0.5784 0.7206 1
0.0497 0.7012 1
0.0404 0.4758 1
0.053 0.7204 0.7204
0.0917 0.4354 0.7604
0.0142 0.5349 0.5155
0.0374 0.4464 0.8955
0.0007 0.5 0.5
0.3798 0.4939 0.4938
0.0088 0.4477 0.4477
0.0367 0.8976 1
0.036 0.4214 1
0.0153 0.3874 0.3874
0.3154 0.6679 0.6679
0.168 0.5725 0.5721
0.1243 0.6685 1
0.1078 0.2561 0.2421
0.0321 0.4417 0.4417
0.008 0.297 0.297
0.0299 0.3752 1
0.6206 0.7273 1
0.0141 0.2722 0.426
0.0716 0.6184 0.6184
0.0158 0.8906 1
0.0088 0.2708 0.2708
0.0037 1 0.5
0.5784 0.7206 1
0.0159 0.4268 0.7705
0.0026 0.5 0.5
0.0036 0.5 0.5
0.0071 0.6442 0.5932
0.0212512 1 1
0.009 0.2566 0.4924
0.0747 0.9532 1
0.0475 0.591 0.9636
0.0012 0.5 0.5
0.0926 0.9454 1
0.5784 0.7206 1
0.0220641 0.692257 0.978776
0.05 0.5719 1
0.0162 0.3894 0
0.0231 0.477 0.4691
0.0088 0.2559 0.2062
0.1447 0.533 0.8995
0.0018 0.5 0.5
0.0672 0.251 0.2503
0.0059 1 1
0.0193 0.2755 0.3416
0.007 0.7208 0.7208
0.0162 0.4409 0.7654
0.2065 0.8021 0.8016
0.0396 0.3628 0.3628
0.0827 0.5995 1
0.6206 0.7273 1
0.0438 0.5707 1
0.0088 0.5642 0.5642
0.0747 0.9532 1
0.0747 0.9532 1
0.0098 0.3242 0.2614
0.0091 1 1
0.0087 0.2972 0.2972
0.0088 0.4303 0.6338
0.0297 0.278 0.3
0.1704 0.3859 0.3859
0.009 0.2566 0.4924
0.0087 0.5162 0
0.0747 0.9532 1
0.2444 0.7455 0.7455
0.0438 0.5707 1
0.0554 0.8948 1
0.0317 0.4517 0.4517
0.0554 0.8948 1
0.0042 0.5 0.5
0.0222 0.3112 1
0.0222 0.4435 0.4435
0.0062 0.6935 0.7231
0.0312 0.3267 1
0.0543 0.5881 1
0.2444 0.7455 0.7455
0.2444 0.7455 0.7455
0.0294 0.4346 0.4308
0.2444 0.7455 0.7455
0.0827 0.5995 1
0.0008 0.5 0.5
0.0326 0.4423 0.4423
0.0088 0.2931 0.2931
0.2444 0.7455 0.7455
0.0747 0.9532 1
0.0231 0.477 0.4691
0.0312 0.3267 1
0.0699 0.391 0.391
0.225 0.918 1
0.2444 0.7455 0.7455
0.0243 0.2667 0.847
0.0088 0.3774 0.3774
0.0699 0.391 0.391
0.1078 0.2561 0.2421
0.0153 0.3874 0.3874
0.0375 0.4563 1
0.0374 0.4464 0.8955
0.0007 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_52540 (Brugia malayi), Protein kinase domain containing protein
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