Detailed view for Bm1_11520

Basic information

TDR Targets ID: 238835
Brugia malayi, PHD-finger family protein

Source Database / ID:  GenBank

pI: 8.6355 | Length (AA): 2192 | MW (Da): 250127 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00439   Bromodomain
PF00628   PHD-finger
PF02791   DDT domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0035064   methylated histone residue binding  
GO:0016589   NURF complex  
GO:0008270   zinc ion binding  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133298)

Species Accession Gene Product
Brugia malayi Bm1_11520   PHD-finger family protein
Drosophila melanogaster Dmel_CG32346   Enhancer of bithorax
Echinococcus granulosus EgrG_000977000   acetyl coenzyme A C acetyltransferase
Echinococcus multilocularis EmuJ_001115900   fetal alzheimer antigen, falz
Echinococcus multilocularis EmuJ_000977000   acetyl coenzyme A C acetyltransferase
Homo sapiens ENSG00000171634   bromodomain PHD finger transcription factor
Loa Loa (eye worm) LOAG_08322   PHD-finger family protein
Loa Loa (eye worm) LOAG_10716   hypothetical protein
Mus musculus ENSMUSG00000040481   bromodomain PHD finger transcription factor
Schistosoma japonicum Sjp_0081380   expressed protein
Schmidtea mediterranea mk4.001276.06   Nucleosome-remodeling factor subunit NURF301-like

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens bromodomain PHD finger transcription factor Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0029 0.2574 0.2371
0.0032 0.2918 0.2406
0.0662 0.2735 0.273
0.0079 0.2905 1
0.0026 0.2918 0.2406
0.0032 0.2814 0.2435
0.0027 0.2793 0.2406
0.0032 0.2918 0.2406
0.0026 0.2742 0.2742
0.0027 0.2637 0.2194
0.0026 0.2918 0.2545
0.0032 0.2979 0.2406
0.0032 0.2918 0.2406
0.0769 0.2647 0.2647
0.0028 0.2776 0.2501
0.0635 0.2739 0.2729
0.0528 0.2555 0.2555
0.0097 0.2687 0.5347
0.0032 0.2858 0.2406
0.0566 0.2608 0.2608
0.0323 0.3002 0.2993
0.0031 0.2918 0.2505
0.0028 0.2918 0.2435
0.0628 0.2738 0.2727
0.0028 0.2858 0.2406
0.06 0.2867 0.2867
0.0029 0.2979 0.2406
0.0793 0.267 0.2815
0.0769 0.2647 0.2647
0.0028 0.2793 0.2406
0.0026 0.2918 0.2384
0.0029 0.2918 0.2406
0.0032 0.2793 0.2406
0.0262 0.2719 0.2719
0.0032 0.2858 0.2406
0.0032 0.2858 0.2406
0.0028 0.285 0.2406
0.0032 0.2918 0.2471
0.0163 0.312 0.312
0.0032 0.2858 0.2406
0.0026 0.2755 0.2755
0.0032 0.2918 0.2406
0.0032 0.2732 0.2536

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Bm1_11520 (Brugia malayi), PHD-finger family protein
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