Detailed view for Bm1_52610

Basic information

TDR Targets ID: 238962
Brugia malayi, RasGEF domain containing protein
Source Database / ID:  GenBank

pI: 6.5324 | Length (AA): 1081 | MW (Da): 124802 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00617   RasGEF domain
PF00618   RasGEF N-terminal motif

Gene Ontology

Mouse over links to read term descriptions.
GO:0046982   protein heterodimerization activity  
GO:0005622   intracellular  
GO:0005089   Rho guanyl-nucleotide exchange factor activity  
GO:0005085   guanyl-nucleotide exchange factor activity  
GO:0003677   DNA binding  
GO:0035023   regulation of Rho protein signal transduction  
GO:0007264   small GTPase mediated signal transduction  
GO:0051056   regulation of small GTPase mediated signal transduction  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
29 1064 3ksy (A) 12 1002 36.00 0 1 1.23217 0.29
39 208 4m6b (A) 37 213 21.00 0.2 1 0.473562 -1.16
234 1050 1xd4 (A) 198 988 43.00 0 1 1.04508 0.21
822 1073 2ije (S) 1027 1258 26.00 0 1 0.537917 -0.72

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128862)

Species Accession Gene Product
Brugia malayi Bm1_52610   RasGEF domain containing protein
Candida albicans CaO19.14188   cell division cycle protein
Candida albicans CaO19.6926   cell division cycle protein
Caenorhabditis elegans CELE_T28F12.3   Protein SOS-1
Drosophila melanogaster Dmel_CG7793   Son of sevenless
Entamoeba histolytica EHI_148500   Ras guanine nucleotide exchange factor, putative
Entamoeba histolytica EHI_139450   Ras guanine nucleotide exchange factor, putative
Homo sapiens ENSG00000115904   son of sevenless homolog 1 (Drosophila)
Homo sapiens ENSG00000100485   son of sevenless homolog 2 (Drosophila)
Loa Loa (eye worm) LOAG_02079   RasGEF domain-containing protein
Mus musculus ENSMUSG00000024241   son of sevenless homolog 1 (Drosophila)
Mus musculus ensembl-mmu:ENSMUSG00000034801   son of sevenless homolog 2 (Drosophila)
Saccharomyces cerevisiae YLR310C   Cdc25p
Schistosoma japonicum Sjp_0016840   Protein son of sevenless, putative
Schistosoma mansoni Smp_035190.2   ras GTP exchange factor son of sevenless
Schmidtea mediterranea mk4.020659.02   Protein son of sevenless
Schmidtea mediterranea mk4.011929.02   Protein son of sevenless
Schmidtea mediterranea mk4.020659.00   Protein son of sevenless
Trypanosoma cruzi TcCLB.507093.270   guanine nucleotide releasing protein, putative
Trichomonas vaginalis TVAG_180350   ras GTP exchange factor, putative
Trichomonas vaginalis TVAG_149260   ras GTP exchange factor, putative
Trichomonas vaginalis TVAG_471030   ras guanine nucleotide exchange factor, slime mold, putative
Trichomonas vaginalis TVAG_083970   ras GTP exchange factor, son of sevenless, putative

Essentiality

Bm1_52610 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T28F12.3 Caenorhabditis elegans slow growth wormbase
CELE_T28F12.3 Caenorhabditis elegans sterile wormbase
YLR310C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_52610 (Brugia malayi), RasGEF domain containing protein
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