Detailed view for Bm1_00185

Basic information

TDR Targets ID: 239474
Brugia malayi, 40S ribosomal protein S26
Source Database / ID:  GenBank

pI: 11.4629 | Length (AA): 65 | MW (Da): 7453 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01283   Ribosomal protein S26e

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 51 4kzy (a) 57 107 76.00 0 1 1.49422 1.44
29 58 3sde (A) 249 278 30.00 0 0.05 0.941738 -1.92

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127138)

Species Accession Gene Product
Arabidopsis thaliana AT2G40590   40S ribosomal protein S26-1
Arabidopsis thaliana AT3G56340   40S ribosomal protein S26-3
Arabidopsis thaliana AT2G40510   40S ribosomal protein S26-2
Babesia bovis BBOV_III002940   ribosomal protein S26e, putative
Brugia malayi Bm1_00185   40S ribosomal protein S26
Brugia malayi Bm1_00195   40S ribosomal protein S26
Candida albicans CaO19.1470   likely cytosolic ribosomal protein similar to S. cerevisiae RPS26A (YGL189C) and RPS26B (YER131W) small subunit protein S26
Candida albicans CaO19.9045   likely cytosolic ribosomal protein similar to S. cerevisiae RPS26A (YGL189C) and RPS26B (YER131W) small subunit protein S26
Caenorhabditis elegans CELE_F39B2.6   Protein RPS-26
Cryptosporidium parvum cgd1_2270   40S ribosomal protein S26
Dictyostelium discoideum DDB_G0281677   40S ribosomal protein S26
Drosophila melanogaster Dmel_CG10305   Ribosomal protein S26
Echinococcus granulosus EgrG_000659300   ribosomal protein s26
Echinococcus granulosus EgrG_000659600   ribosomal protein s26
Entamoeba histolytica EHI_158550   40S ribosomal protein S26, putative
Entamoeba histolytica EHI_039010   40S ribosomal protein S26, putative
Entamoeba histolytica EHI_105180   40S ribosomal protein S26, putative
Echinococcus multilocularis EmuJ_000659600   ribosomal protein s26
Echinococcus multilocularis EmuJ_000659300   ribosomal protein s26
Giardia lamblia GL50803_17364   Ribosomal protein S26
Homo sapiens ENSG00000197728   ribosomal protein S26
Homo sapiens 101929876   40S ribosomal protein S26-like
Homo sapiens 100996747   40S ribosomal protein S26-like
Leishmania braziliensis LbrM.28.0560   ribosomal protein S26, putative
Leishmania braziliensis LbrM.30.3230   ribosomal protein S26, putative
Leishmania donovani LdBPK_280570.1   ribosomal protein S26, putative
Leishmania donovani LdBPK_303240.1   ribosomal protein S26, putative
Leishmania infantum LinJ.30.3240   ribosomal protein S26, putative
Leishmania infantum LinJ.28.0570   ribosomal protein S26, putative
Leishmania major LmjF.30.3200   ribosomal protein S26, putative
Leishmania major LmjF.28.0540   ribosomal protein S26, putative
Leishmania mexicana LmxM.29.3200   ribosomal protein S26, putative
Leishmania mexicana LmxM.28.0540   ribosomal protein S26, putative
Loa Loa (eye worm) LOAG_00472   hypothetical protein
Mus musculus ENSMUSG00000025362   ribosomal protein S26
Mus musculus 102642963   40S ribosomal protein S26-like
Neospora caninum NCLIV_018290   Ribosomal protein S26E, related
Oryza sativa 4339104   Os05g0477300
Oryza sativa 4327570   Os01g0823300
Oryza sativa 9272278   Os03g0816200
Plasmodium berghei PBANKA_0314500   40S ribosomal protein S26, putative
Plasmodium falciparum PF3D7_0217800   40S ribosomal protein S26
Plasmodium knowlesi PKNH_0403100   40S ribosomal protein S26, putative
Plasmodium vivax PVX_002650   40S ribosomal protein S26, putative
Plasmodium yoelii PY04712   Ribosomal protein S26e
Saccharomyces cerevisiae YGL189C   ribosomal 40S subunit protein S26A
Saccharomyces cerevisiae YER131W   ribosomal 40S subunit protein S26B
Schistosoma japonicum Sjp_0049180   IPR000892,Ribosomal protein S26E,domain-containing
Schistosoma japonicum Sjp_0122690   expressed protein
Schistosoma japonicum Sjp_0049740   ko:K02976 small subunit ribosomal protein S26e, putative
Schistosoma mansoni Smp_031310   40S ribosomal protein S26
Schistosoma mansoni Smp_183650   40S ribosomal protein S26
Schmidtea mediterranea mk4.009838.01   40S ribosomal protein S26
Trypanosoma brucei gambiense Tbg972.11.9370   ribosomal protein S26, putative
Trypanosoma brucei Tb927.11.8200   ribosomal protein S26, putative
Trypanosoma cruzi TcCLB.508817.60   ribosomal protein S26, putative
Trypanosoma cruzi TcCLB.503801.20   ribosomal protein S26, putative
Toxoplasma gondii TGME49_243570   ribosomal protein RPS26
Theileria parva TP01_0980   40S ribosomal protein S26e, putative
Trichomonas vaginalis TVAG_164600   40S ribosomal protein S26, putative
Trichomonas vaginalis TVAG_302160   40S ribosomal protein S26, putative
Trichomonas vaginalis TVAG_347960   40S ribosomal protein S26, putative
Trichomonas vaginalis TVAG_333200   40S ribosomal protein S26, putative
Trichomonas vaginalis TVAG_040120   40S ribosomal protein S26, putative
Trichomonas vaginalis TVAG_242190   40S ribosomal protein S26, putative
Trichomonas vaginalis TVAG_061920   40S ribosomal protein S26, putative
Trichomonas vaginalis TVAG_277940   40S ribosomal protein S26, putative
Trichomonas vaginalis TVAG_335820   40S ribosomal protein S26, putative

Essentiality

Bm1_00185 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.0355 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.0355 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.0355 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.0355 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F39B2.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_F39B2.6 Caenorhabditis elegans larval arrest wormbase
CELE_F39B2.6 Caenorhabditis elegans larval lethal wormbase
CELE_F39B2.6 Caenorhabditis elegans slow growth wormbase
CELE_F39B2.6 Caenorhabditis elegans terminal arrest variable wormbase
YGL189C Saccharomyces cerevisiae inviable yeastgenome
TGME49_243570 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Bm1_00185 (Brugia malayi), 40S ribosomal protein S26
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