Detailed view for Bm1_57535

Basic information

TDR Targets ID: 239675
Brugia malayi, Ubiquitin fusion degradation protein UFD1 containing protein
Source Database / ID:  GenBank

pI: 6.3503 | Length (AA): 320 | MW (Da): 35279 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03152   Ubiquitin fusion degradation protein UFD1

Gene Ontology

Mouse over links to read term descriptions.
GO:0006511   ubiquitin-dependent protein catabolic process  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 202 1zc1 (A) 1 206 46.00 0 1 1.11235 0.21
6 194 2yuj (A) 1 190 56.00 0 1 1.22353 -0.09

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127577)

Species Accession Gene Product
Arabidopsis thaliana AT2G21270   ubiquitin fusion degradation 1
Arabidopsis thaliana AT4G38930   ubiquitin fusion degradation UFD1 family protein
Arabidopsis thaliana AT2G29070   ubiquitin fusion degradation UFD1-like protein
Babesia bovis BBOV_II005920   ubiquitin fusion degradation protein, putative
Brugia malayi Bm1_57535   Ubiquitin fusion degradation protein UFD1 containing protein
Candida albicans CaO19.13255   ubiquitin fusion degradation protein
Candida albicans CaO19.5833   ubiquitin fusion degradation protein
Caenorhabditis elegans CELE_F19B6.2   Protein UFD-1, isoform B
Cryptosporidium hominis Chro.40141   hypothetical protein
Cryptosporidium parvum cgd4_1200   ubiquitin fusion degradation protein (UFD1); double Psi beta barrel fold
Dictyostelium discoideum DDB_G0271122   ubiquitin fusion degradation protein UFD1 family protein
Drosophila melanogaster Dmel_CG6233   Ubiquitin fusion-degradation 1-like
Echinococcus granulosus EgrG_000786200   ubiquitin fusion degradation protein 1
Entamoeba histolytica EHI_125920   ubiquitin fusion degradation protein 1 homolog, putative
Echinococcus multilocularis EmuJ_000786200   ubiquitin fusion degradation protein 1
Giardia lamblia GL50803_3994   Ubiquitin fusion degradation protein 1
Homo sapiens ENSG00000070010   ubiquitin fusion degradation 1 like (yeast)
Leishmania braziliensis LbrM.35.6830   ubiquitin fusion degradation protein, putative
Leishmania braziliensis LbrM.35.6940   ubiquitin fusion degradation protein, putative
Leishmania donovani LdBPK_366780.1   ubiquitin fusion degradation protein, putative
Leishmania infantum LinJ.36.6780   ubiquitin fusion degradation protein, putative
Leishmania major LmjF.36.6490   ubiquitin fusion degradation protein, putative
Leishmania mexicana LmxM.36.6490   ubiquitin fusion degradation protein, putative
Loa Loa (eye worm) LOAG_04983   ubiquitin fusion degradation protein UFD1 containing protein
Mus musculus ENSMUSG00000005262   ubiquitin fusion degradation 1 like
Neospora caninum NCLIV_036230   Ubiquitin fusion-degradation protein (ISS), related
Oryza sativa 4336742   Os04g0577000
Oryza sativa 4328514   Os02g0181800
Plasmodium berghei PBANKA_1024700   ubiquitin fusion degradation protein UFD1, putative
Plasmodium falciparum PF3D7_1418000   ubiquitin fusion degradation protein UFD1, putative
Plasmodium knowlesi PKNH_1340000   ubiquitin fusion degradation protein UFD1, putative
Plasmodium vivax PVX_085555   ubiquitin fusion degradation protein, putative
Plasmodium yoelii PY01641   hypothetical protein
Saccharomyces cerevisiae YGR048W   polyubiquitin-binding protein UFD1
Schistosoma japonicum Sjp_0032290   Ubiquitin fusion degradation protein 1 homolog, putative
Schistosoma mansoni Smp_144460.1   ubiquitin fusion degradaton protein
Schistosoma mansoni Smp_144460.2   ubiquitin fusion degradaton protein
Schmidtea mediterranea mk4.000501.08   Ubiquitin fusion degradation protein 1 homolog
Schmidtea mediterranea mk4.004163.05   Ubiquitin fusion degradation protein 1 homolog
Schmidtea mediterranea mk4.022630.00   Ubiquitin fusion degradation protein 1 homolog
Schmidtea mediterranea mk4.000501.05   Ubiquitin fusion degradation protein 1 homolog
Schmidtea mediterranea mk4.009103.00   Ubiquitin fusion degradation protein 1 homolog
Schmidtea mediterranea mk4.022630.01   Ubiquitin fusion degradation protein 1 homolog
Schmidtea mediterranea mk4.025564.00   Ubiquitin fusion degradation protein 1 homolog
Schmidtea mediterranea mk4.029243.00   Ubiquitin fusion degradation protein 1 homolog
Schmidtea mediterranea mk4.000839.03   Ubiquitin fusion degradation protein 1 homolog
Schmidtea mediterranea mk4.000501.06   Ubiquitin fusion degradation protein 1 homolog
Schmidtea mediterranea mk4.036498.01   Ubiquitin fusion degradation protein 1 homolog
Trypanosoma brucei gambiense Tbg972.10.9550   ubiquitin fusion degradation protein, putative
Trypanosoma brucei Tb927.10.7790   ubiquitin fusion degradation protein, putative
Trypanosoma congolense TcIL3000_10_6650   ubiquitin fusion degradation protein, putative
Trypanosoma cruzi TcCLB.504167.40   ubiquitin fusion degradation protein, putative
Trypanosoma cruzi TcCLB.398235.20   ubiquitin fusion degardation protein, putative
Toxoplasma gondii TGME49_270530   ubiquitin fusion degradation protein UFD1CY
Theileria parva TP02_0530   hypothetical protein
Trichomonas vaginalis TVAG_024980   ubiquitin fusion degradaton protein, putative
Trichomonas vaginalis TVAG_055050   ubiquitin fusion degradaton protein, putative
Trichomonas vaginalis TVAG_009810   conserved hypothetical protein
Trichomonas vaginalis TVAG_276420   ubiquitin fusion degradaton protein, putative

Essentiality

Bm1_57535 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.7790 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.7790 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.7790 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.7790 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F19B6.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_F19B6.2 Caenorhabditis elegans larval arrest wormbase
CELE_F19B6.2 Caenorhabditis elegans larval lethal wormbase
CELE_F19B6.2 Caenorhabditis elegans slow growth wormbase
CELE_F19B6.2 Caenorhabditis elegans sterile wormbase
YGR048W Saccharomyces cerevisiae inviable yeastgenome
TGME49_270530 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Bm1_57535 (Brugia malayi), Ubiquitin fusion degradation protein UFD1 containing protein
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