pI: 7.0546 |
Length (AA): 326 |
MW (Da): 35419 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
15 | 325 | 2h9l (A) | 14 | 333 | 36.00 | 0.00000000025 | 1 | 1.30599 | -0.17 |
68 | 325 | 2h9l (A) | 23 | 333 | 81.00 | 0 | 1 | 1.57371 | -1.15 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128632)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G49660 | COMPASS-like H3K4 histone methylase component WDR5A |
Brugia malayi | Bm1_28000 | Will die slowly protein |
Candida albicans | CaO19.10961 | WD40 repeat protein similar to S. cerevisiae SWD3 (YBR175W) COMPASS histone methyltransferase complex component |
Candida albicans | CaO19.3457 | WD40 repeat protein similar to S. cerevisiae SWD3 (YBR175W) COMPASS histone methyltransferase complex component |
Caenorhabditis elegans | CELE_C14B1.4 | Protein WDR-5.1 |
Dictyostelium discoideum | DDB_G0287273 | WD40 repeat-containing protein |
Drosophila melanogaster | Dmel_CG17437 | will die slowly |
Echinococcus granulosus | EgrG_001184200 | protein will die slowly |
Echinococcus multilocularis | EmuJ_001184200 | protein will die slowly |
Homo sapiens | ENSG00000196363 | WD repeat domain 5 |
Homo sapiens | ENSG00000196981 | WD repeat domain 5B |
Loa Loa (eye worm) | LOAG_03831 | WD40 repeat protein |
Mus musculus | ENSMUSG00000026917 | WD repeat domain 5 |
Mus musculus | ENSMUSG00000034379 | WD repeat domain 5B |
Oryza sativa | 4333964 | Os03g0725400 |
Onchocerca volvulus | OVOC3321 |
|
Saccharomyces cerevisiae | YBR175W | Swd3p |
Schistosoma japonicum | Sjp_0094150 | WD repeat-containing protein 5, putative |
Schistosoma mansoni | Smp_046750 | hypothetical protein |
Schmidtea mediterranea | mk4.002606.02 | |
Schmidtea mediterranea | mk4.004394.01 | |
Trichomonas vaginalis | TVAG_032580 | WD repeat domain, putative |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | WD repeat domain 5 | Compounds | References |