Affected Entity |
Phenotypic quality |
Occurs in |
Occurs at |
Evidence |
Observed in |
Drugs/Inhibitors |
growth (GO:0040007)
|
decreased time (PATO:0000716)
|
single cell organism (CARO:0000064)
|
promastigote (BTO:0001124)
|
inferred from bioassay (ECO:0000094)
|
Leishmania donovani
|
No drug identifiers listed for this gene.
|
Annotator: |
aaronjr@u.washington.edu. |
Comment: |
Drug: (azasterols) 623550-27-6; Drug: 383365-51-3; Drug: 383365-46-6; Drug: 185993-05-9; Drug: 171782-23-3. chemical inhibition with sterol 24-c-methyltransferase (2.1.1.41) inhibitors leads to slow growth of Leishmania sp. in cell assay; Q6RW42_LEIDO; azasterol inhibitors. |
References: |
7755579
|
growth (GO:0040007)
|
decreased time (PATO:0000716)
|
single cell organism (CARO:0000064)
|
promastigote (BTO:0001124)
|
inferred from bioassay (ECO:0000094)
|
Leishmania mexicana
|
No drug identifiers listed for this gene.
|
Annotator: |
aaronjr@u.washington.edu. |
Comment: |
Drug: (azasterols) 623550-27-6; Drug: 383365-51-3; Drug: 383365-46-6; Drug: 185993-05-9; Drug: 171782-23-3. chemical inhibition with sterol 24-c-methyltransferase (2.1.1.41) inhibitors leads to slow growth of Leishmania sp. in cell assay; low dose leads to membrane disruption, but not cell death (high dose leads to cell inviability); Q6RW42_LEIDO; azasterol inhibitors. |
References: |
11796362
|
growth (GO:0040007)
|
decreased time (PATO:0000716)
|
single cell organism (CARO:0000064)
|
promastigote (BTO:0001124)
|
inferred from bioassay (ECO:0000094)
|
Leishmania donovani
|
No drug identifiers listed for this gene.
|
Annotator: |
aaronjr@u.washington.edu. |
Comment: |
Drug: (azasterols) 623550-27-6; Drug: 383365-51-3; Drug: 383365-46-6; Drug: 185993-05-9; Drug: 171782-23-3. chemical inhibition with sterol 24-c-methyltransferase (2.1.1.41) inhibitors leads to slow growth of Leishmania sp. in cell assay; low dose leads to membrane disruption, but not cell death (high dose leads to cell inviability); Q6RW42_LEIDO; azasterol inhibitors. |
References: |
11796362
|
growth (GO:0040007)
|
decreased time (PATO:0000716)
|
single cell organism (CARO:0000064)
|
promastigote (BTO:0001124)
|
inferred from bioassay (ECO:0000094)
|
Leishmania amazonensis
|
No drug identifiers listed for this gene.
|
Annotator: |
aaronjr@u.washington.edu. |
Comment: |
Drug: (azasterols) 623550-27-6; Drug: 383365-51-3; Drug: 383365-46-6; Drug: 185993-05-9; Drug: 171782-23-3. chemical inhibition with sterol 24-c-methyltransferase (2.1.1.41) inhibitors leads to slow growth of Leishmania sp. in cell assay; low dose leads to membrane disruption, but not cell death (high dose leads to cell inviability); Q6RW42_LEIDO; azasterol inhibitors. |
References: |
11796362
|
growth (GO:0040007)
|
decreased time (PATO:0000716)
|
single cell organism (CARO:0000064)
|
amastigote (BTO:0000062)
|
inferred from bioassay (ECO:0000094)
|
Leishmania mexicana
|
No drug identifiers listed for this gene.
|
Annotator: |
aaronjr@u.washington.edu. |
Comment: |
Drug: (azasterols) 623550-27-6; Drug: 383365-51-3; Drug: 383365-46-6; Drug: 185993-05-9; Drug: 171782-23-3. chemical inhibition with sterol 24-c-methyltransferase (2.1.1.41) inhibitors leads to slow growth of Leishmania sp. in cell assay; low dose leads to membrane disruption, but not cell death (high dose leads to cell inviability); Q6RW42_LEIDO; azasterol inhibitors. |
References: |
11796362
|
growth (GO:0040007)
|
decreased time (PATO:0000716)
|
single cell organism (CARO:0000064)
|
amastigote (BTO:0000062)
|
inferred from bioassay (ECO:0000094)
|
Leishmania donovani
|
No drug identifiers listed for this gene.
|
Annotator: |
aaronjr@u.washington.edu. |
Comment: |
Drug: (azasterols) 623550-27-6; Drug: 383365-51-3; Drug: 383365-46-6; Drug: 185993-05-9; Drug: 171782-23-3. chemical inhibition with sterol 24-c-methyltransferase (2.1.1.41) inhibitors leads to slow growth of Leishmania sp. in cell assay; low dose leads to membrane disruption, but not cell death (high dose leads to cell inviability); Q6RW42_LEIDO; azasterol inhibitors. |
References: |
11796362
|
growth (GO:0040007)
|
decreased time (PATO:0000716)
|
single cell organism (CARO:0000064)
|
amastigote (BTO:0000062)
|
inferred from bioassay (ECO:0000094)
|
Leishmania amazonensis
|
No drug identifiers listed for this gene.
|
Annotator: |
aaronjr@u.washington.edu. |
Comment: |
Drug: (azasterols) 623550-27-6; Drug: 383365-51-3; Drug: 383365-46-6; Drug: 185993-05-9; Drug: 171782-23-3. chemical inhibition with sterol 24-c-methyltransferase (2.1.1.41) inhibitors leads to slow growth of Leishmania sp. in cell assay; low dose leads to membrane disruption, but not cell death (high dose leads to cell inviability); Q6RW42_LEIDO; azasterol inhibitors. |
References: |
11796362
|
plasma membrane (GO:0005886)
|
disrupted (PATO:0001507)
|
single cell organism (CARO:0000064)
|
promastigote (BTO:0001124)
|
inferred from visible phenotype (ECO:0000176)
|
Leishmania mexicana
|
No drug identifiers listed for this gene.
|
Annotator: |
aaronjr@u.washington.edu. |
Comment: |
Drug: (azasterols) 623550-27-6; Drug: 383365-51-3; Drug: 383365-46-6; Drug: 185993-05-9; Drug: 171782-23-3. chemical inhibition with sterol 24-c-methyltransferase (2.1.1.41) inhibitors leads to slow growth of Leishmania sp. in cell assay; low dose leads to membrane disruption, but not cell death (high dose leads to cell inviability); Q6RW42_LEIDO; azasterol inhibitors. |
References: |
11796362
|
plasma membrane (GO:0005886)
|
disrupted (PATO:0001507)
|
single cell organism (CARO:0000064)
|
promastigote (BTO:0001124)
|
inferred from visible phenotype (ECO:0000176)
|
Leishmania donovani
|
No drug identifiers listed for this gene.
|
Annotator: |
aaronjr@u.washington.edu. |
Comment: |
Drug: (azasterols) 623550-27-6; Drug: 383365-51-3; Drug: 383365-46-6; Drug: 185993-05-9; Drug: 171782-23-3. chemical inhibition with sterol 24-c-methyltransferase (2.1.1.41) inhibitors leads to slow growth of Leishmania sp. in cell assay; low dose leads to membrane disruption, but not cell death (high dose leads to cell inviability); Q6RW42_LEIDO; azasterol inhibitors. |
References: |
11796362
|
plasma membrane (GO:0005886)
|
disrupted (PATO:0001507)
|
single cell organism (CARO:0000064)
|
promastigote (BTO:0001124)
|
inferred from visible phenotype (ECO:0000176)
|
Leishmania amazonensis
|
No drug identifiers listed for this gene.
|
Annotator: |
aaronjr@u.washington.edu. |
Comment: |
Drug: (azasterols) 623550-27-6; Drug: 383365-51-3; Drug: 383365-46-6; Drug: 185993-05-9; Drug: 171782-23-3. chemical inhibition with sterol 24-c-methyltransferase (2.1.1.41) inhibitors leads to slow growth of Leishmania sp. in cell assay; low dose leads to membrane disruption, but not cell death (high dose leads to cell inviability); Q6RW42_LEIDO; azasterol inhibitors. |
References: |
11796362
|
plasma membrane (GO:0005886)
|
disrupted (PATO:0001507)
|
single cell organism (CARO:0000064)
|
amastigote (BTO:0000062)
|
inferred from visible phenotype (ECO:0000176)
|
Leishmania mexicana
|
No drug identifiers listed for this gene.
|
Annotator: |
aaronjr@u.washington.edu. |
Comment: |
Drug: (azasterols) 623550-27-6; Drug: 383365-51-3; Drug: 383365-46-6; Drug: 185993-05-9; Drug: 171782-23-3. chemical inhibition with sterol 24-c-methyltransferase (2.1.1.41) inhibitors leads to slow growth of Leishmania sp. in cell assay; low dose leads to membrane disruption, but not cell death (high dose leads to cell inviability); Q6RW42_LEIDO; azasterol inhibitors. |
References: |
11796362
|
plasma membrane (GO:0005886)
|
disrupted (PATO:0001507)
|
single cell organism (CARO:0000064)
|
amastigote (BTO:0000062)
|
inferred from visible phenotype (ECO:0000176)
|
Leishmania donovani
|
No drug identifiers listed for this gene.
|
Annotator: |
aaronjr@u.washington.edu. |
Comment: |
Drug: (azasterols) 623550-27-6; Drug: 383365-51-3; Drug: 383365-46-6; Drug: 185993-05-9; Drug: 171782-23-3. chemical inhibition with sterol 24-c-methyltransferase (2.1.1.41) inhibitors leads to slow growth of Leishmania sp. in cell assay; low dose leads to membrane disruption, but not cell death (high dose leads to cell inviability); Q6RW42_LEIDO; azasterol inhibitors. |
References: |
11796362
|
plasma membrane (GO:0005886)
|
disrupted (PATO:0001507)
|
single cell organism (CARO:0000064)
|
amastigote (BTO:0000062)
|
inferred from visible phenotype (ECO:0000176)
|
Leishmania amazonensis
|
No drug identifiers listed for this gene.
|
Annotator: |
aaronjr@u.washington.edu. |
Comment: |
Drug: (azasterols) 623550-27-6; Drug: 383365-51-3; Drug: 383365-46-6; Drug: 185993-05-9; Drug: 171782-23-3. chemical inhibition with sterol 24-c-methyltransferase (2.1.1.41) inhibitors leads to slow growth of Leishmania sp. in cell assay; low dose leads to membrane disruption, but not cell death (high dose leads to cell inviability); Q6RW42_LEIDO; azasterol inhibitors. |
References: |
11796362
|
growth (GO:0040007)
|
decreased time (PATO:0000716)
|
single cell organism (CARO:0000064)
|
promastigote (BTO:0001124)
|
inferred from bioassay (ECO:0000094)
|
Leishmania amazonensis
|
No drug identifiers listed for this gene.
|
Annotator: |
aaronjr@u.washington.edu. |
Comment: |
Drug: azasterols. chemical inhibition with sterol 24-c-methyltransferase (2.1.1.41) inhibitors leads to slow growth of Leishmania sp. in cell assay; low dose leads to membrane disruption, but not cell death (high dose leads to cell inviability); azasterol inhibitors. |
References: |
14561091
|
growth (GO:0040007)
|
decreased time (PATO:0000716)
|
single cell organism (CARO:0000064)
|
amastigote (BTO:0000062)
|
inferred from bioassay (ECO:0000094)
|
Leishmania amazonensis
|
No drug identifiers listed for this gene.
|
Annotator: |
aaronjr@u.washington.edu. |
Comment: |
Drug: azasterols. chemical inhibition with sterol 24-c-methyltransferase (2.1.1.41) inhibitors leads to slow growth of Leishmania sp. in cell assay; low dose leads to membrane disruption, but not cell death (high dose leads to cell inviability); azasterol inhibitors. |
References: |
14561091
|
plasma membrane (GO:0005886)
|
disrupted (PATO:0001507)
|
single cell organism (CARO:0000064)
|
promastigote (BTO:0001124)
|
inferred from visible phenotype (ECO:0000176)
|
Leishmania amazonensis
|
No drug identifiers listed for this gene.
|
Annotator: |
aaronjr@u.washington.edu. |
Comment: |
Drug: azasterols. chemical inhibition with sterol 24-c-methyltransferase (2.1.1.41) inhibitors leads to slow growth of Leishmania sp. in cell assay; low dose leads to membrane disruption, but not cell death (high dose leads to cell inviability); azasterol inhibitors. |
References: |
14561091
|
plasma membrane (GO:0005886)
|
disrupted (PATO:0001507)
|
single cell organism (CARO:0000064)
|
amastigote (BTO:0000062)
|
inferred from visible phenotype (ECO:0000176)
|
Leishmania amazonensis
|
No drug identifiers listed for this gene.
|
Annotator: |
aaronjr@u.washington.edu. |
Comment: |
Drug: azasterols. chemical inhibition with sterol 24-c-methyltransferase (2.1.1.41) inhibitors leads to slow growth of Leishmania sp. in cell assay; low dose leads to membrane disruption, but not cell death (high dose leads to cell inviability); azasterol inhibitors. |
References: |
14561091
|
catalytic activity (GO:0003824)
|
decreased (PATO:0000468)
|
in vitro (MI:0492)
|
|
inferred from specific protein inhibition (ECO:0000020)
|
Leishmania major
|
No drug identifiers listed for this gene.
|
Annotator: |
aaronjr@u.washington.edu. |
Comment: |
Drug: azasterols. chemical inhibition with sterol 24-c-methyltransferase (2.1.1.41) inhibitors leads to reduced enzyme activity in vitro; azasterol inhibitors. |
References: |
14561091
16046134
|
growth (GO:0040007)
|
decreased time (PATO:0000716)
|
single cell organism (CARO:0000064)
|
amastigote (BTO:0000062)
|
inferred from bioassay (ECO:0000094)
|
Leishmania donovani
|
No drug identifiers listed for this gene.
|
Annotator: |
aaronjr@u.washington.edu. |
Comment: |
Drug: azasterols. chemical inhibition with sterol 24-c-methyltransferase (2.1.1.41) inhibitors leads to slow growth of Leishmania sp. in cell assay; Q6RW42_LEIDO; azasterol inhibitors. |
References: |
16046134
|