pI: 4.3937 |
Length (AA): 505 |
MW (Da): 55205 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 500 | 1z3h (B) | 371 | 908 | 11.00 | 0 | 1 | 0.982219 | 0.45 |
71 | 476 | 4uae (A) | 71 | 486 | 76.00 | 0 | 1 | 1.82006 | -2.02 |
116 | 386 | 4v3r (A) | 13 | 291 | 36.00 | 0 | 1 | 1.11073 | -1.65 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126761)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G02690 | importin alpha isoform 6 |
Arabidopsis thaliana | AT1G09270 | importin alpha isoform 4 |
Arabidopsis thaliana | AT4G16143 | importin alpha isoform 2 |
Arabidopsis thaliana | AT5G49310 | importin alpha isoform 5 |
Arabidopsis thaliana | AT3G06720 | Importin subunit alpha-1 |
Arabidopsis thaliana | AT4G02150 | Importin alpha 3 |
Babesia bovis | BBOV_III009880 | armadillo/beta-catenin-like repeat domain containing protein |
Brugia malayi | Bm1_32450 | Importin alpha-3 subunit |
Candida albicans | CaO19.5682 | Karyopherin-alpha or importin |
Caenorhabditis elegans | CELE_F32E10.4 | Protein IMA-3 |
Cryptosporidium hominis | Chro.80378 | importin alpha |
Cryptosporidium parvum | cgd8_3260 | importin alpha subunit |
Dictyostelium discoideum | DDB_G0272318 | hypothetical protein |
Drosophila melanogaster | Dmel_CG8548 | karyopherin alpha1 |
Drosophila melanogaster | Dmel_CG9423 | karyopherin alpha3 |
Echinococcus granulosus | EgrG_000479600 | importin subunit alpha 3 |
Entamoeba histolytica | EHI_148070 | importin alpha, putative |
Entamoeba histolytica | EHI_179940 | hypothetical protein |
Entamoeba histolytica | EHI_025350 | importin alpha, putative |
Echinococcus multilocularis | EmuJ_000479600 | importin subunit alpha 3 |
Homo sapiens | ENSG00000025800 | karyopherin alpha 6 (importin alpha 7) |
Homo sapiens | ENSG00000114030 | karyopherin alpha 1 (importin alpha 5) |
Homo sapiens | ENSG00000102753 | karyopherin alpha 3 (importin alpha 4) |
Homo sapiens | ENSG00000186432 | karyopherin alpha 4 (importin alpha 3) |
Homo sapiens | ENSG00000196911 | karyopherin alpha 5 (importin alpha 6) |
Leishmania braziliensis | LbrM.30.1240 | importin alpha, putative |
Leishmania donovani | LdBPK_301180.1 | importin alpha, putative |
Leishmania infantum | LinJ.30.1180 | importin alpha, putative |
Leishmania major | LmjF.30.1120 | importin alpha, putative |
Leishmania mexicana | LmxM.29.1120 | importin alpha, putative |
Loa Loa (eye worm) | LOAG_14865 | hypothetical protein |
Loa Loa (eye worm) | LOAG_01346 | importin alpha-3 subunit |
Mus musculus | ENSMUSG00000022905 | karyopherin (importin) alpha 1 |
Mus musculus | ENSMUSG00000027782 | karyopherin (importin) alpha 4 |
Mus musculus | ENSMUSG00000021929 | karyopherin (importin) alpha 3 |
Mus musculus | ENSMUSG00000003731 | karyopherin (importin) alpha 6 |
Neospora caninum | NCLIV_007390 | MGC78841 protein, related |
Oryza sativa | 4327117 | Os01g0253300 |
Oryza sativa | 4326488 | Os01g0343200 |
Oryza sativa | 4337853 | Os05g0155500 |
Plasmodium berghei | PBANKA_1425100 | karyopherin alpha, putative |
Plasmodium falciparum | PF3D7_0812400 | karyopherin alpha |
Plasmodium knowlesi | PKNH_1428200 | karyopherin alpha, putative |
Plasmodium vivax | PVX_123150 | karyopherin alpha, putative |
Plasmodium yoelii | PY01795 | putative impotin alpha 1b |
Saccharomyces cerevisiae | YNL189W | karyopherin alpha |
Schistosoma japonicum | Sjp_0070960 | Importin subunit alpha-3, putative |
Schistosoma mansoni | Smp_051210.1 | importin alpha 34 |
Schistosoma mansoni | Smp_051210.3 | importin alpha 34 |
Schmidtea mediterranea | mk4.007993.00 | |
Schmidtea mediterranea | mk4.003549.01 | |
Schmidtea mediterranea | mk4.022525.00 | Importin subunit alpha-3 |
Schmidtea mediterranea | mk4.031324.00 | Importin subunit alpha-3 |
Schmidtea mediterranea | mk4.007005.00 | Importin subunit alpha-3 |
Schmidtea mediterranea | mk4.003829.03 | Importin subunit alpha-3 |
Trypanosoma brucei gambiense | Tbg972.6.2400 | importin alpha subunit, putative |
Trypanosoma brucei | Tb927.6.2640 | importin alpha subunit, putative |
Trypanosoma congolense | TcIL3000_6_2120 | importin alpha subunit, putative |
Trypanosoma cruzi | TcCLB.509965.110 | importin alpha, putative |
Trypanosoma cruzi | TcCLB.509057.20 | importin alpha, putative |
Toxoplasma gondii | TGME49_252290 | importin alpha, putative |
Theileria parva | TP04_0908 | importin alpha, putative |
Trichomonas vaginalis | TVAG_235230 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.2640 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.2640 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.2640 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.6.2640 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F32E10.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F32E10.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F32E10.4 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F32E10.4 | Caenorhabditis elegans | sterile | wormbase |
YNL189W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1425100 | Plasmodium berghei | Essential | plasmo |
TGME49_252290 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.