Detailed view for Bm1_57590

Basic information

TDR Targets ID: 240063
Brugia malayi, glycosyl transferase, group 1 family protein
Source Database / ID:  GenBank

pI: 7.9355 | Length (AA): 594 | MW (Da): 68137 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13692   Glycosyl transferases group 1

Gene Ontology

Mouse over links to read term descriptions.
GO:0016757   transferase activity, transferring glycosyl groups  
GO:0009058   biosynthetic process  

Metabolic Pathways

N-Glycan biosynthesis (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
301 479 2bfw (A) 219 390 19.00 0 1 0.521847 -0.76

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128548)

Species Accession Gene Product
Arabidopsis thaliana AT1G16570   UDP-glycosyltransferase superfamily protein
Brugia malayi Bm1_57590   glycosyl transferase, group 1 family protein
Candida albicans CaO19.4410   Beta-mannosyltransferase
Candida albicans CaO19.11888   Beta-mannosyltransferase
Caenorhabditis elegans CELE_T26A5.4   Protein T26A5.4
Cryptosporidium hominis Chro.70211   glycosyl transferase
Cryptosporidium parvum cgd7_1810   ALG1 like beta-1,4 mannosyltransferase with possible signal peptide
Dictyostelium discoideum DDB_G0286011   hypothetical protein
Drosophila melanogaster Dmel_CG18012   CG18012 gene product from transcript CG18012-RC
Echinococcus granulosus EgrG_000194200   chitobiosyldiphosphodolichol
Entamoeba histolytica EHI_028950   chitobiosyldiphosphodolichol beta-mannosyltransferase, putative
Echinococcus multilocularis EmuJ_000194200   chitobiosyldiphosphodolichol
Homo sapiens 101060670   chitobiosyldiphosphodolichol beta-mannosyltransferase-like
Homo sapiens 56052   ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
Leishmania braziliensis LbrM.18.0960   dolichyl-P-Man:GDP-ManGlcNAc2-PP-dolichyl beta-1,4-mannosyltransferase, putative
Leishmania donovani LdBPK_180900.1   glycosyltransferase, putative
Leishmania infantum LinJ.18.0900   dolichyl-P-Man:GDP-ManGlcNAc2-PP-dolichyl beta-1,4-mannosyltransferase, putative
Leishmania major LmjF.18.0900   dolichyl-P-Man:GDP-ManGlcNAc2-PP-dolichyl beta-1,4-mannosyltransferase, putative
Leishmania mexicana LmxM.18.0900   glycosyltransferase, putative
Loa Loa (eye worm) LOAG_01802   glycosyl transferase
Mus musculus ENSMUSG00000039427   asparagine-linked glycosylation 1 (beta-1,4-mannosyltransferase)
Neospora caninum NCLIV_031100   hypothetical protein
Oryza sativa 4331831   Os03g0180700
Oryza sativa 4341323   Os06g0564800
Saccharomyces cerevisiae YBR110W   chitobiosyldiphosphodolichol beta-1,4 mannosyltransferase
Schistosoma japonicum Sjp_0077160   ko:K03842 beta-1,4-mannosyltransferase, putative
Schistosoma mansoni Smp_005010   chitobiosyldiphosphodolichol alpha-mannosyltransferase
Schmidtea mediterranea mk4.019538.00   Chitobiosyldiphosphodolichol beta-mannosyltransferase
Schmidtea mediterranea mk4.008395.00   Chitobiosyldiphosphodolichol alpha-mannosyltransferase
Schmidtea mediterranea mk4.009979.01   Chitobiosyldiphosphodolichol alpha-mannosyltransferase
Trypanosoma brucei gambiense Tbg972.10.15970   glycosyltransferase, putative
Trypanosoma brucei Tb11.v5.0694   glycosyltransferase, putative
Trypanosoma congolense TcIL3000_10_11300   glycosyltransferase, putative
Trypanosoma cruzi TcCLB.508891.10   dolichyl-P-Man:GDP-ManGlcNAc2-PP-dolichyl beta-1,4-mannosyltransferase, putative
Trypanosoma cruzi TcCLB.504215.20   dolichyl-P-Man:GDP-ManGlcNAc2-PP-dolichyl beta-1,4-mannosyltransferase, putative
Toxoplasma gondii TGME49_230590   chitobiosyldiphosphodolichol beta-mannosyltransferase
Trichomonas vaginalis TVAG_061110   beta1,4 mannosyltransferase, putative

Essentiality

Bm1_57590 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.13210 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.13210 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.13210 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.13210 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T26A5.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_T26A5.4 Caenorhabditis elegans sterile wormbase
YBR110W Saccharomyces cerevisiae inviable yeastgenome
TGME49_230590 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Bm1_57590 (Brugia malayi), glycosyl transferase, group 1 family protein
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