Detailed view for Bm1_44405

Basic information

TDR Targets ID: 240400
Brugia malayi, oxidoreductase, short chain dehydrogenase/reductase family protein
Source Database / ID:  GenBank

pI: 8.2485 | Length (AA): 282 | MW (Da): 31077 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00106   short chain dehydrogenase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016491   oxidoreductase activity  
GO:0005488   binding  
GO:0003824   catalytic activity  
GO:0008152   metabolic process  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 282 3gdg (A) 16 247 24.00 0 1 1.0581 0.09
2 278 1n5d (A) 2 279 39.00 0 1 1.56337 -1.44
6 275 1wma (A) 6 276 40.00 0 1 1.51255 -1.29
6 143 1yxm (A) 20 157 25.00 0.0063 1 0.967262 -1.58

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128075)

Species Accession Gene Product
Arabidopsis thaliana AT1G01800   Rossmann-fold NAD(P)-binding domain-containing protein
Arabidopsis thaliana AT2G24190   Short-chain dehydrogenase/reductase 2
Arabidopsis thaliana AT5G51030   Rossmann-fold NAD(P)-binding domain-containing protein
Arabidopsis thaliana AT3G61220   (+)-neomenthol dehydrogenase
Arabidopsis thaliana AT3G59710   Rossmann-fold NAD(P)-binding domain-containing protein
Arabidopsis thaliana AT5G61830   NAD(P)-binding Rossmann-fold superfamily protein
Brugia malayi Bm1_44405   oxidoreductase, short chain dehydrogenase/reductase family protein
Echinococcus granulosus EgrG_000114400   carbonyl reductase 1
Echinococcus granulosus EgrG_000114500   carbonyl reductase 1
Echinococcus granulosus EgrG_000115300   carbonyl reductase 1
Echinococcus granulosus EgrG_000113500   carbonyl reductase 1
Echinococcus granulosus EgrG_000115200   carbonyl reductase 1
Echinococcus multilocularis EmuJ_000115200   carbonyl reductase 1
Echinococcus multilocularis EmuJ_000113500   carbonyl reductase 1
Echinococcus multilocularis EmuJ_000114500   carbonyl reductase 1
Echinococcus multilocularis EmuJ_000114300   carbonyl reductase 1
Echinococcus multilocularis EmuJ_000114400   carbonyl reductase 1
Echinococcus multilocularis EmuJ_000115300   carbonyl reductase 1
Homo sapiens ENSG00000159231   carbonyl reductase 3
Homo sapiens ENSG00000159228   carbonyl reductase 1
Leishmania braziliensis LbrM.34.1150   short chain dehydrogenase, putative
Leishmania donovani LdBPK_351240.1   short chain dehydrogenase, putative
Leishmania infantum LinJ.35.1240   short chain dehydrogenase, putative
Leishmania major LmjF.35.1230   short chain dehydrogenase, putative
Leishmania mexicana LmxM.34.1230   short chain dehydrogenase, putative
Mus musculus ENSMUSG00000051483   carbonyl reductase 1
Mus musculus ENSMUSG00000022947   carbonyl reductase 3
Mus musculus 102641578   carbonyl reductase [NADPH] 1-like
Mus musculus 102642943   carbonyl reductase [NADPH] 1-like
Neospora caninum NCLIV_042760   Dehydrogenases with different specificities, related
Oryza sativa 4344332   Os07g0685800
Oryza sativa 4336497   Os04g0532400
Oryza sativa 4329932   Os02g0607700
Oryza sativa 4336495   Os04g0532100
Oryza sativa 4336494   Os04g0531900
Oryza sativa 4336492   Os04g0531700
Oryza sativa 4326939   Os01g0929500
Oryza sativa 9271852   Os04g0531750
Onchocerca volvulus OVOC8261  
Schistosoma japonicum Sjp_0075840   ko:K00079 carbonyl reductase (NADPH) [EC1.1.1.184], putative
Schistosoma japonicum Sjp_0128240   Carbonyl reductase [NADPH] 1, putative
Schistosoma mansoni Smp_033530.1   carbonyl reductase
Schistosoma mansoni Smp_033530.3   carbonyl reductase
Schistosoma mansoni Smp_140270   carbonyl reductase
Schistosoma mansoni Smp_033540   carbonyl reductase
Schmidtea mediterranea mk4.039386.02  
Schmidtea mediterranea mk4.008144.00  
Trypanosoma cruzi TcCLB.508297.50   short chain dehydrogenase, putative
Trypanosoma cruzi TcCLB.508805.80   short chain dehydrogenase, putative
Toxoplasma gondii TGME49_290890   carbonyl reductase 1, putative

Essentiality

Bm1_44405 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_290890 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens carbonyl reductase 3 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0089 0.5 0.5
0.0119 0.2746 1
0.0114 1 1
0.0032 1 1
0.016 0.577 1
0.0045 1 1
0.0057 0.284 0.2725
0.0027 0.5 0.5
0.0196 0.8679 0.8679
0.0165 1 1
0.0009 0.5 0.5
0.0222 0.5 0.5
0.0218 0.5 0.5
0.0089 0.5 0.5
0.0073 0.3811 0.3811
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0009 0.5 0.5
0.0019 0.4322 1
0.0102 0.7451 1
0.0039 1 1
0.0053 1 1
0.0009 1 0.5
0.0097 0.4304 1
0.0088 0.6544 0.6544
0.0131 0.5 0.5
0.0108 0.5 0.5
0.0056 0.875 0.875
0.0073 0.3141 1
0.0118 1 1
0.0058 0.3931 0.5176
0.0073 0.2873 0.2873
0.0196 0.8679 0.8679
0.0021 0.3321 0.3321
0.0113 1 1
0.011 0.3568 0.3568
0.0004 0.5 0.5
0.004 0.5 0.5
0.0097 1 1
0.0068 0.2585 0.4116
0.0082 1 1
0.0073 0.3811 0.3811
0.0408 0.5144 0.8021
0.0106 0.2872 0.4415
0.0093 0.5 0.5
0.0106 1 1
0.0009 0.5 0.5
0.0132 0.3658 0.3658
0.0046 0.3082 0
0.0009 0.7374 0.7374
0.008 0.5 0.5
0.0004 0.5 0.5
0.0171 0.4063 0.3122
0.007 1 1
0.0005 0.5 0.5
0.0004 0.5 0.5
0.0067 0.3468 0.3468
0.0106 0.5 0.5
0.0088 1 1
0.0058 1 1
0.0004 0.5 0.5
0.0053 1 1
0.0087 0.5 0.5
0.0009 0.5 0.5
0.0071 0.3141 0.3141
0.0026 0.5 0.5
0.0056 1 1
0.0084 0.4283 0.4283
0.0013 1 1
0.0157 0.5 0.5
0.007 1 1
0.0009 0.5 0.5
0.0064 0.3508 0.3956
0.0085 1 1
0.0408 0.5144 0.8021
0.0171 0.4063 0.3122
0.0123 0.5 0.5
0.0027 0.5 0.5
0.0005 0.5 0.5
0.0021 0.5 0.5
0.0106 1 1
0.0004 0.5 0.5
0.003 0.4425 0.5985
0.007 0.2916 0.4349
0.0408 0.5144 0.8021
0.0021 0.3321 0.3321
0.0016 0.5 0.5
0.0013 0.5 0.5
0.0035 1 1
0.0012 0.5 0.5
0.0068 1 1
0.0196 0.8679 0.8679
0.016 0.577 1
0.0076 1 1
0.0114 1 1
0.0009 0.5 0.5
0.0012 0.5 0.5
0.007 0.2916 0.4349
0.0073 0.4546 0.4546
0.0009 0.5 0.5
0.0402 1 1
0.007 0.2916 0.4349
0.0009 0.5 0.5
0.0066 0.3586 0.3586
0.007 1 1
0.0162 1 1
0.0068 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_44405 (Brugia malayi), oxidoreductase, short chain dehydrogenase/reductase family protein
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