Detailed view for Bm1_23790

Basic information

TDR Targets ID: 240741
Brugia malayi, Coelomocyte uptake defective protein 5
Source Database / ID:  GenBank

pI: 5.8696 | Length (AA): 643 | MW (Da): 73995 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 6

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF08016   Polycystin cation channel

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005216   ion channel activity  
GO:0006811   ion transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
92 310 5tjb (A) 89 281 24.00 0 0.86 0.133591 0.82
489 589 5hj8 (A) 180 284 32.00 0.11 0.05 0.175476 1.62

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129484)

Species Accession Gene Product
Brugia malayi Bm1_23790   Coelomocyte uptake defective protein 5
Caenorhabditis elegans CELE_R13A5.1   Protein CUP-5, isoform C
Dictyostelium discoideum DDB_G0291275   hypothetical protein
Drosophila melanogaster Dmel_CG8743   Transient receptor potential cation channel, mucolipin ortholog
Drosophila melanogaster Dmel_CG42638   CG42638 gene product from transcript CG42638-RA
Echinococcus granulosus EgrG_001106300   mucolipin 3
Echinococcus multilocularis EmuJ_001106300   mucolipin 3
Homo sapiens ENSG00000153898   mucolipin 2
Homo sapiens ENSG00000055732   mucolipin 3
Homo sapiens ENSG00000090674   mucolipin 1
Loa Loa (eye worm) LOAG_04987   mucolipin 1
Mus musculus ENSMUSG00000036853   mucolipin 3
Mus musculus ENSMUSG00000004567   mucolipin 1
Mus musculus ENSMUSG00000011008   mucolipin 2
Schistosoma japonicum Sjp_0200840   ko:K04994 mucolipin 3, putative
Schistosoma japonicum Sjp_0129760   expressed protein
Schistosoma mansoni Smp_190090   mucolipin
Schistosoma mansoni Smp_166210   mucolipin
Schmidtea mediterranea mk4.017880.01  
Schmidtea mediterranea mk4.015549.00  
Schmidtea mediterranea mk4.008303.02  
Schmidtea mediterranea mk4.019855.00  
Schmidtea mediterranea mk4.008303.00  
Schmidtea mediterranea mk4.017880.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens mucolipin 3 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0127 0.2996 0.5376
0.0269 0.3743 0.4088
0.0063 0.2515 0.2515
0.0131 0.2591 0.2596
0.0067 0.3143 0.3143
0.0071 0.5764 0.5394
0.0071 0.4242 0.4242
0.0329 0.2603 0.448
0.0329 0.2603 0.448
0.013 0.298 0.5481
0.0253 0.3739 0.5191
0.0063 0.8858 0.8747
0.0079 0.2728 0.3144
0.0079 0.2728 0.3144
0.0132 0.2634 0.255
0.0135 0.3043 0.5586
0.0079 0.2515 0.2515
0.013 0.2586 0.3808
0.007 0.2642 0.2521
0.0133 0.2642 0.263
0.0071 0.5764 0.5394
0.0079 0.3143 0.3143
0.013 0.2597 0.2597
0.0076 0.278 0.2708
0.0329 0.2603 0.448
0.0127 0.2748 0.5284
0.0132 0.2596 0.2596
0.0079 0.5537 0.5436
0.0137 0.3858 0.7879
0.0065 0.4123 0.3519
0.0131 0.3077 0.5493
0.0071 0.4296 0.4296
0.0071 0.5764 0.5394
0.0127 0.2748 0.5284
0.0139 0.2771 0.2771
0.0065 0.3532 0.4559
0.0329 0.2603 0.448
0.0132 0.2596 0.2596
0.0064 0.2505 0.2505
0.0065 0.4042 0.392
0.0197 0.4656 0.4832

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_23790 (Brugia malayi), Coelomocyte uptake defective protein 5
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