Detailed view for Bm1_00225

Basic information

TDR Targets ID: 240763
Brugia malayi, protein ZC84.6

Source Database / ID:  GenBank

pI: 5.0986 | Length (AA): 469 | MW (Da): 53063 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00014   Kunitz/Bovine pancreatic trypsin inhibitor domain
PF01683   EB module

Gene Ontology

Mouse over links to read term descriptions.
GO:0004867   serine-type endopeptidase inhibitor activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_141765)

Species Accession Gene Product
Brugia malayi Bm1_13500   EB module family protein
Brugia malayi Bm1_00225   protein ZC84.6
Caenorhabditis elegans CELE_ZC84.6   Protein ZC84.6
Caenorhabditis elegans CELE_T22F7.5   Protein T22F7.5
Caenorhabditis elegans CELE_Y55F3BR.2   Protein Y55F3BR.2
Caenorhabditis elegans CELE_ZC84.1   Protein ZC84.1
Caenorhabditis elegans CELE_T22F7.3   Protein T22F7.3
Caenorhabditis elegans CELE_F30H5.3   Protein F30H5.3
Echinococcus multilocularis EmuJ_000077700   Kunitz:Bovine pancreatic trypsin inhibitor
Loa Loa (eye worm) LOAG_14886   hypothetical protein
Loa Loa (eye worm) LOAG_14394   hypothetical protein
Loa Loa (eye worm) LOAG_09210   hypothetical protein
Loa Loa (eye worm) LOAG_08007   hypothetical protein
Loa Loa (eye worm) LOAG_14440   hypothetical protein

Essentiality

Bm1_00225 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y55F3BR.2 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_00225 (Brugia malayi), protein ZC84.6
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