pI: 8.0777 |
Length (AA): 451 |
MW (Da): 51693 |
Paralog Number:
182
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
78 | 450 | 1miq (A) | 78 | 327 | 58.00 | 0 | 1 | 1.67 | -1.84 |
77 | 451 | 3qvc (A) | 77 | 328 | 99.99 | 0 | 1 | 2.08169 | -1.7 |
222 | 449 | 3qrv (A) | 98 | 326 | 68.00 | 0.0000015 | 1 | 1.22494 | -0.83 |
371 | 449 | 1b5f (B) | 249 | 326 | 32.00 | 0.000033 | 0.44 | 0.475566 | 0.28 |
404 | 449 | 1j71 (A) | 283 | 324 | 36.00 | 0.077 | 0.1 | 0.0173956 | 2.21 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Ring. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Oocyst. | Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Sporozoite, Male Gametocyte. | Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Female Gametocyte. | Lasonder E |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Compound | Source | Reference |
---|---|---|
ChEMBL23 | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Callithrix jacchus | Renin | 400 aa | 29.8% | 336 aa | Compounds | References |
Macaca fascicularis | Renin | 406 aa | 29.8% | 346 aa | Compounds | References |
Oryctolagus cuniculus | Renin | 280 aa | 27.8% | 284 aa | Compounds | References |
Plasmodium vivax | plasmepsin IV, putative | 450 aa | 52.7% | 450 aa | Compounds | References |
Macaca mulatta | Renin | 406 aa | 29.9% | 345 aa | Compounds | References |
Rattus norvegicus | Renin | 402 aa | 29.9% | 345 aa | Compounds | References |
Penicillium janthinellum | Penicillopepsin | 323 aa | 20.4% | 309 aa | Compounds | References |
Bos taurus | Cathepsin D | 390 aa | 27.0% | 344 aa | Compounds | References |
Sus scrofa | Pepsin A | 385 aa | 26.2% | 363 aa | Compounds | References |
Rattus norvegicus | Pepsinogen C | 392 aa | 26.5% | 373 aa | Compounds | References |
140 literature references were collected for this gene.