Detailed view for Bm1_48265

Basic information

TDR Targets ID: 241171
Brugia malayi, Endonuclease/Exonuclease/phosphatase family protein
Source Database / ID:  GenBank

pI: 6.6098 | Length (AA): 671 | MW (Da): 76641 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03372   Endonuclease/Exonuclease/phosphatase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0046856   phosphoinositide dephosphorylation  
GO:0004437   inositol or phosphatidylinositol phosphatase activity  

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
15 363 4cmn (A) 219 559 41.00 0 1 1.04402 -0.69
30 346 4cml (A) 259 567 42.00 0 1 1.06033 -1.33
48 337 2imq (X) 20 280 30.00 0 0.97 0.654091 0.22
367 631 3qis (A) 563 883 29.00 0 1 0.688533 -0.08
367 631 3qis (A) 563 883 32.00 0 1 0.621833 0
371 637 3qis (A) 567 889 25.00 0 1 0.646814 0.26
572 669 5jd0 (A) 1007 1105 14.00 0.0065 0.09 0.362951 -0.83

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127907)

Species Accession Gene Product
Arabidopsis thaliana AT2G43900   5-inositol-phosphate phosphatase
Arabidopsis thaliana AT2G01900   DNAse I-like superfamily protein
Arabidopsis thaliana AT2G31830   Type II inositol-1,4,5-trisphosphate 5-phosphatase 14
Arabidopsis thaliana AT1G65580   Type II inositol-1,4,5-trisphosphate 5-phosphatase FRA3
Arabidopsis thaliana AT2G37440   DNAse I-like superfamily protein
Arabidopsis thaliana AT1G05630   Type I inositol-1,4,5-trisphosphate 5-phosphatase 13
Brugia malayi Bm1_48265   Endonuclease/Exonuclease/phosphatase family protein
Caenorhabditis elegans CELE_C16C2.3   Protein OCRL-1, isoform B
Dictyostelium discoideum DDB_G0267462   RhoGAP domain-containing protein
Drosophila melanogaster Dmel_CG3573   Oculocerebrorenal syndrome of Lowe ortholog (H. sapiens)
Echinococcus granulosus EgrG_000933200   inositol polyphosphate 5 phosphatase OCRL 1
Entamoeba histolytica EHI_159880   inositol polyphosphate 5-phosphatase, putative
Entamoeba histolytica EHI_153490   inositol polyphosphate 5-phosphatase, putative
Entamoeba histolytica EHI_088450   inositol polyphosphate 5-phosphatase, putative
Entamoeba histolytica EHI_160860   inositol polyphosphate 5-phosphatase, putative
Entamoeba histolytica EHI_046590   inositol polyphosphate-5-phosphatase, putative
Echinococcus multilocularis EmuJ_000933200   inositol polyphosphate 5 phosphatase OCRL 1
Giardia lamblia GL50803_14787   Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor
Homo sapiens ENSG00000204084   inositol polyphosphate-5-phosphatase, 75kDa
Homo sapiens ENSG00000122126   oculocerebrorenal syndrome of Lowe
Leishmania braziliensis LbrM.15.1160   inositol/phosphatidylinositol phosphatase, putative
Leishmania donovani LdBPK_151210.1   inositol/phosphatidylinositol phosphatase, putative
Leishmania infantum LinJ.15.1210   inositol/phosphatidylinositol phosphatase, putative
Leishmania major LmjF.15.1210   inositol/phosphatidylinositol phosphatase, putative
Leishmania mexicana LmxM.15.1210   inositol/phosphatidylinositol phosphatase, putative
Loa Loa (eye worm) LOAG_00438   endonuclease/Exonuclease/phosphatase
Loa Loa (eye worm) LOAG_00437   hypothetical protein
Mus musculus ENSMUSG00000001173   oculocerebrorenal syndrome of Lowe
Mus musculus ENSMUSG00000028894   inositol polyphosphate-5-phosphatase B
Oryza sativa 4347481   Os09g0500300
Oryza sativa 4346083   Os08g0524100
Oryza sativa 4332194   Os03g0238300
Schistosoma japonicum Sjp_0107640   IPR005135,Endonuclease/exonuclease/phosphatase,domain-containing
Schistosoma japonicum Sjp_0110430   Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor, putative
Schistosoma japonicum Sjp_0039020   Inositol polyphosphate 5-phosphatase OCRL-1, putative
Schistosoma mansoni Smp_064190   ocrl type II inositol 5-phosphatase
Schmidtea mediterranea mk4.009732.04  
Schmidtea mediterranea mk4.002358.00  
Schmidtea mediterranea mk4.004490.00  
Trypanosoma brucei gambiense Tbg972.9.3000   inositol/phosphatidylinositol phosphatase, putative
Trypanosoma brucei Tb927.9.5680   inositol/phosphatidylinositol phosphatase, putative
Trypanosoma congolense TcIL3000_9_1900   inositol/phosphatidylinositol phosphatase, putative
Trichomonas vaginalis TVAG_373240   skeletal muscle/kidney enriched inositol 5-phosphatase, putative

Essentiality

Bm1_48265 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.160.4180 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.160.4180 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.160.4180 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.160.4180 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_48265 (Brugia malayi), Endonuclease/Exonuclease/phosphatase family protein
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