Detailed view for Bm1_00455

Basic information

TDR Targets ID: 241300
Brugia malayi, RAMP4-2
Source Database / ID:  GenBank

pI: 10.74 | Length (AA): 59 | MW (Da): 6592 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06624   Ribosome associated membrane protein RAMP4

Gene Ontology

Mouse over links to read term descriptions.
GO:0005783   endoplasmic reticulum  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130196)

Species Accession Gene Product
Arabidopsis thaliana AT1G27350   ribosome associated membrane protein RAMP4
Arabidopsis thaliana AT1G27330   ribosome associated membrane protein RAMP4
Brugia malayi Bm1_00455   RAMP4-2
Caenorhabditis elegans CELE_T09A12.5   Protein T09A12.5
Caenorhabditis elegans CELE_F59F4.2   Protein F59F4.2
Cryptosporidium parvum cgd2_140   conserved hypothetical protein
Dictyostelium discoideum DDB_G0275381   hypothetical protein
Drosophila melanogaster Dmel_CG32276   CG32276 gene product from transcript CG32276-RB
Echinococcus granulosus EgrG_000414500   ribosome associated membrane protein 4
Echinococcus multilocularis EmuJ_000414500   ribosome associated membrane protein 4
Homo sapiens ENSG00000120742   stress-associated endoplasmic reticulum protein 1
Homo sapiens ENSG00000151778   stress-associated endoplasmic reticulum protein family member 2
Loa Loa (eye worm) LOAG_00998   hypothetical protein
Mus musculus ENSMUSG00000052584   stress-associated endoplasmic reticulum protein family member 2
Mus musculus ENSMUSG00000027808   stress-associated endoplasmic reticulum protein 1
Neospora caninum NCLIV_068620   Ribosome associated membrane domain-containing protein, putative
Oryza sativa 4350985   Os11g0637400
Oryza sativa 4343733   Os07g0583000
Oryza sativa 4352336   Os12g0514100
Onchocerca volvulus OVOC2392  
Plasmodium berghei PBANKA_0315800   ribosome associated membrane protein RAMP4, putative
Plasmodium falciparum PF3D7_0219400   ribosome associated membrane protein RAMP4, putative, unspecified product
Plasmodium knowlesi PKNH_0401500   ribosome associated membrane protein RAMP4, putative
Plasmodium vivax PVX_002585   ribosome associated membrane protein RAMP4, putative
Plasmodium yoelii PY04494   Arabidopsis thaliana F17L21.12-related
Schistosoma japonicum Sjp_0308650   IPR010580,Ribosome associated membrane RAMP4,domain-containing
Schistosoma mansoni Smp_089570   stress associated endoplasmic reticulum protein (serp1/ramp4)
Schmidtea mediterranea mk4.044350.00   Putative stress associated endoplasmic reticulum protein
Schmidtea mediterranea mk4.015384.01   Putative stress associated endoplasmic reticulum protein
Toxoplasma gondii TGME49_276940   ribosome associated membrane protein RAMP4, putative

Essentiality

Bm1_00455 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0315800 Plasmodium berghei Dispensable plasmo
TGME49_276940 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_00455 (Brugia malayi), RAMP4-2
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