Detailed view for Bm1_46305

Basic information

TDR Targets ID: 241356
Brugia malayi, Deoxynucleoside kinase family protein
Source Database / ID:  GenBank

pI: 6.4011 | Length (AA): 440 | MW (Da): 51920 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01712   Deoxynucleoside kinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0006120   mitochondrial electron transport, NADH to ubiquinone  
GO:0005747   mitochondrial respiratory chain complex I  
GO:0005524   ATP binding  

Metabolic Pathways

Oxidative phosphorylation (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
76 299 2no7 (A) 20 251 18.00 0 1 0.699191 -0.27
78 300 2no7 (B) 22 256 19.00 0 0.99 0.653918 -0.23

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132722)

Species Accession Gene Product
Brugia malayi Bm1_46305   Deoxynucleoside kinase family protein
Caenorhabditis elegans CELE_K04G7.4   Protein NUO-4, isoform B
Dictyostelium discoideum DDB_G0280843   deoxyguanosine kinase
Drosophila melanogaster Dmel_CG6343   NADH:ubiquinone reductase 42kD subunit precursor
Echinococcus granulosus EgrG_000345800   NADH ubiquinone oxidoreductase 42 kDa subunit
Echinococcus multilocularis EmuJ_000345800   NADH ubiquinone oxidoreductase 42 kDa subunit
Giardia lamblia GL50803_4558   Deoxyguanosine kinase/deoxyadenosine kinase subunit, putative
Homo sapiens ENSG00000130414   NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
Loa Loa (eye worm) LOAG_05118   deoxynucleoside kinase
Mus musculus 67273   NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10
Schistosoma japonicum Sjp_0210550   ko:K03954 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10, putative
Schistosoma mansoni Smp_031710   NADH-ubiquinone oxidoreductase

Essentiality

Bm1_46305 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_K04G7.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_K04G7.4 Caenorhabditis elegans larval arrest wormbase
CELE_K04G7.4 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0458 0.2904 0.6643
0.0229 0.2679 0.6249
0.0473 0.2826 0.638
0.0484 0.2877 0.6546
0.0442 0.3281 0.6381
0.0215 0.2755 0.6356
0.0229 0.2679 0.6249
0.0454 0.3342 0.6478
0.0467 0.2769 0.6388
0.0464 0.3296 0.6381
0.0478 0.2895 0.6473
0.0455 0.3334 0.6473
0.0222 0.2653 0.6249
0.0448 0.2585 0.6381
0.0449 0.3325 0.6464
0.0458 0.2722 0.6518
0.0222 0.2653 0.6249
0.0265 0.2679 0.6249
0.0265 0.3105 0.623
0.0451 0.2685 0.6381
0.0495 0.2939 0.6574
0.0224 0.2679 0.6249
0.0445 0.3592 0.6729
0.0444 0.3297 0.6435
0.0445 0.3592 0.6729
0.0468 0.2861 0.6398
0.0474 0.3283 0.6381
0.0448 0.3307 0.6446
0.0224 0.2679 0.6249
0.0458 0.2722 0.6518

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_46305 (Brugia malayi), Deoxynucleoside kinase family protein
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