Detailed view for Bm1_00255

Basic information

TDR Targets ID: 241588
Brugia malayi, Notch signaling pathway homolog protein 1

Source Database / ID:  GenBank

pI: 7.2064 | Length (AA): 1719 | MW (Da): 192288 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13871   C-terminal domain on Strawberry notch homologue
PF13872   P-loop containing NTP hydrolase pore-1

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
80 446 4kf7 (A) 702 1092 13.00 0 0.03 0.244496 -0.19
906 1046 5bw9 (c) 377 512 33.00 0.11 0.12 -0.0344756 1.99
1039 1159 2nca (A) 10 125 16.00 0 0.02 0.17439 -0.53

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein


No expression data available for this gene


Ortholog group members (OG5_129178)

Species Accession Gene Product
Arabidopsis thaliana AT1G79350   protein EMBRYO DEFECTIVE 1135
Brugia malayi Bm1_00255   Notch signaling pathway homolog protein 1
Brugia malayi Bm1_00875   Notch signaling pathway homolog protein 1
Caenorhabditis elegans CELE_F20H11.2   Protein LET-765
Drosophila melanogaster Dmel_CG3491   CG3491 gene product from transcript CG3491-RA
Drosophila melanogaster Dmel_CG44437   CG44437 gene product from transcript CG44437-RA
Drosophila melanogaster Dmel_CG44436   strawberry notch
Echinococcus granulosus EgrG_001078200   protein strawberry notch 1
Echinococcus multilocularis EmuJ_001078200   protein strawberry notch 1
Homo sapiens ENSG00000139697   strawberry notch homolog 1 (Drosophila)
Homo sapiens ENSG00000064932   strawberry notch homolog 2 (Drosophila)
Loa Loa (eye worm) LOAG_07043   hypothetical protein
Loa Loa (eye worm) LOAG_14264   hypothetical protein
Mus musculus ENSMUSG00000038095   sno, strawberry notch homolog 1 (Drosophila)
Mus musculus ENSMUSG00000035673   strawberry notch homolog 2 (Drosophila)
Oryza sativa 9269679   Os04g0609850
Oryza sativa 4344965   Os08g0223700
Oryza sativa 4336941   Os04g0609700
Schistosoma japonicum Sjp_0201740   expressed protein
Schistosoma mansoni Smp_160030   strawberry notch-related
Schmidtea mediterranea mk4.001594.04  


Bm1_00255 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F20H11.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_F20H11.2 Caenorhabditis elegans larval lethal wormbase
CELE_F20H11.2 Caenorhabditis elegans slow growth wormbase
CELE_F20H11.2 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site,, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model


Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_00255 (Brugia malayi), Notch signaling pathway homolog protein 1
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