Detailed view for Bm1_50265

Basic information

TDR Targets ID: 241679
Brugia malayi, Protein kinase domain containing protein
Source Database / ID:  GenBank

pI: 4.764 | Length (AA): 469 | MW (Da): 53385 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

FoxO signaling pathway (KEGG)
mTOR signaling pathway (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
18 449 3c4w (B) 89 530 23.00 0 1 1.09121 0.41
106 388 2wtk (F) 45 336 52.00 0 1 1.18851 -0.54
107 376 5uyj (A) 162 449 37.00 0 1 1.04479 -0.78

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131104)

Species Accession Gene Product
Brugia malayi Bm1_50265   Protein kinase domain containing protein
Candida albicans CaO19.5376   Serine/threonine protein kinase
Candida albicans CaO19.3068   DNA polymerase alpha suppressing protein kinase.
Candida albicans CaO19.12831   Serine/threonine protein kinase
Caenorhabditis elegans CELE_Y59A8B.14   Protein PAR-4, isoform B
Dictyostelium discoideum DDB_G0279629   CAMKL family protein kinase
Drosophila melanogaster Dmel_CG9374   CG9374 gene product from transcript CG9374-RE
Homo sapiens ENSG00000118046   serine/threonine kinase 11
Loa Loa (eye worm) LOAG_03149   CAMK/CAMKL/LKB protein kinase
Mus musculus 20869   serine/threonine kinase 11
Schmidtea mediterranea mk4.002570.00   Serine/threonine-protein kinase par-4
Trichomonas vaginalis TVAG_319990   CAMK family protein kinase
Trichomonas vaginalis TVAG_351980   CAMK family protein kinase
Trichomonas vaginalis TVAG_374000   CAMK family protein kinase
Trichomonas vaginalis TVAG_425830   CAMK family protein kinase
Trichomonas vaginalis TVAG_032510   CAMK family protein kinase
Trichomonas vaginalis TVAG_404110   CAMK family protein kinase
Trichomonas vaginalis TVAG_192890   CAMK family protein kinase
Trichomonas vaginalis TVAG_388270   CAMK family protein kinase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens serine/threonine kinase 11 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 30.8% 279 aa Compounds References
Xenopus laevis Aurora kinase B-B 368 aa 26.2% 343 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 29.9% 164 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0004 0.5 0.5
0.0059 1 1
0.0036 0.5 0.5
0.0003 0.5 0.5
0.0039 0.9485 1
0.0007 0.5 0.5
0.0032 0.5 0.5
0.0033 1 1
0.0062 0.6935 0.7231
0.0032 0.5 0.5
0.0061 0.6883 0.6808
0.0042 0.5 0.5
0.0064 0.3377 0.3377
0.0011 1 1
0.0008 0.5 0.5
0.0066 0.3101 0
0.0033 0.5 0.5
0.0063 1 1
0.0007 0.5 0.5
0.0023 0.5 0.5
0.0063 0.7244 0
0.0007 0.5 0.5
0.0092 1 1
0.0039 0.5 0.5
0.0069 0.3067 0.9179
0.0098 0.3242 0.2614
0.0016 0.5 0.5
0.0012 0.5 0.5
0.0029 0.5 0.5
0.0039 0.5 0.5
0.0037 1 0.5
0.0056 1 1
0.0026 0.5 0.5
0.0018 0.5 0.5
0.0059 1 1
0.0081 1 1
0.0022 0.5 0.5
0.0012 0.5 0.5
0.0093 0.8828 0
0.0081 0.5 0.5
0.0027 1 1
0.0016 0.5 0.5
0.0012 0.5 0.5
0.0059 1 1
0.0067 0.5 0.5
0.0091 1 1
0.0088 0.4477 0.4477

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_50265 (Brugia malayi), Protein kinase domain containing protein
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