pI: 8.7856 |
Length (AA): 875 |
MW (Da): 100493 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_128423)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G02390 | poly(ADP-ribose) polymerase |
Arabidopsis thaliana | AT2G31320 | poly [ADP-ribose] polymerase 2 |
Brugia malayi | Bm1_50905 | WGR domain containing protein |
Brugia malayi | Bm1_07920 | WGR domain containing protein |
Caenorhabditis elegans | CELE_Y71F9AL.18 | Protein PME-1 |
Dictyostelium discoideum | DDB_G0292820 | NAD+ ADP-ribosyltransferase |
Dictyostelium discoideum | DDB_G0278741 | NAD+ ADP-ribosyltransferase |
Drosophila melanogaster | Dmel_CG40411 | Poly-(ADP-ribose) polymerase |
Echinococcus granulosus | EgrG_002060500 | poly (ADP ribose) polymerase |
Echinococcus granulosus | EgrG_002063300 | WGR domain containing protein |
Echinococcus granulosus | EgrG_000618800 | poly adp ribose polymerase 2 |
Echinococcus granulosus | EgrG_000566400 | poly (ADP ribose) polymerase |
Echinococcus granulosus | EgrG_002059300 | poly (ADP ribose) polymerase |
Echinococcus granulosus | EgrG_000374500 | poly ADP ribose polymerase 1 |
Entamoeba histolytica | EHI_136960 | poly(ADP-ribose) polymerase, putative |
Entamoeba histolytica | EHI_038830 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000566800 | poly (ADP ribose) polymerase |
Echinococcus multilocularis | EmuJ_000374500 | poly (ADP ribose) polymerase 1 |
Echinococcus multilocularis | EmuJ_000618800 | poly (adp ribose) polymerase 2 |
Homo sapiens | ENSG00000143799 | poly (ADP-ribose) polymerase 1 |
Homo sapiens | ENSG00000129484 | poly (ADP-ribose) polymerase 2 |
Loa Loa (eye worm) | LOAG_07925 | hypothetical protein |
Loa Loa (eye worm) | LOAG_03373 | hypothetical protein |
Loa Loa (eye worm) | LOAG_13695 | poly(ADP-ribose) polymerase |
Mus musculus | ENSMUSG00000026496 | poly (ADP-ribose) polymerase family, member 1 |
Mus musculus | ENSMUSG00000036023 | poly (ADP-ribose) polymerase family, member 2 |
Neospora caninum | NCLIV_035940 | hypothetical protein |
Oryza sativa | 4326478 | Os01g0351100 |
Oryza sativa | 4343013 | Os07g0413700 |
Oryza sativa | 4326479 | Os01g0351200 |
Schistosoma japonicum | Sjp_0303330 | ko:K00774 NAD ADP-ribosyltransferase [EC2.4.2.30], putative |
Schistosoma japonicum | Sjp_0069220 | Poly [ADP-ribose] polymerase 2, putative |
Schistosoma japonicum | Sjp_0041610 | Poly [ADP-ribose] polymerase 1, putative |
Schistosoma japonicum | Sjp_0110660 | Poly [ADP-ribose] polymerase 2-A, putative |
Schistosoma japonicum | Sjp_0311610 | Poly [ADP-ribose] polymerase 2, putative |
Schistosoma japonicum | Sjp_0086100 | Poly [ADP-ribose] polymerase 1, putative |
Schistosoma mansoni | Smp_145810.2 | poly [ADP-ribose] polymerase |
Schistosoma mansoni | Smp_145810.1 | poly [ADP-ribose] polymerase |
Schistosoma mansoni | Smp_129260 | poly [ADP-ribose] polymerase |
Schmidtea mediterranea | mk4.001452.11 | |
Schmidtea mediterranea | mk4.005407.00 | Poly |
Schmidtea mediterranea | mk4.005407.01 | Poly |
Schmidtea mediterranea | mk4.013382.00 | Poly |
Schmidtea mediterranea | mk4.003480.01 | Poly(ADP-ribose) polymerase pme-2 |
Trypanosoma brucei gambiense | Tbg972.5.4270 | poly(ADP-ribose) polymerase, putative |
Trypanosoma brucei | Tb927.5.3050 | poly(adp-ribose) polymerase |
Trypanosoma congolense | TcIL3000_5_3380 | poly(ADP-ribose) polymerase, putative |
Trypanosoma cruzi | TcCLB.510173.90 | poly(ADP-ribose) polymerase, putative |
Trypanosoma cruzi | TcCLB.509721.60 | poly(ADP-ribose) polymerase, putative |
Toxoplasma gondii | TGME49_270840 | poly(ADP-ribose) polymerase catalytic domain-containing protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.3050 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.3050 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.3050 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.5.3050 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_270840 | Toxoplasma gondii | Probably non-essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mus musculus | poly (ADP-ribose) polymerase family, member 1 | Compounds | References |
Homo sapiens | poly (ADP-ribose) polymerase 2 | Compounds | References |
Bos taurus | Poly [ADP-ribose] polymerase 1 | Compounds | References |
Rattus norvegicus | Poly [ADP-ribose] polymerase 1 | Compounds | References |
Mus musculus | poly (ADP-ribose) polymerase family, member 2 | Compounds | References |
Homo sapiens | poly (ADP-ribose) polymerase 1 | Compounds | References |