pI: 7.3033 |
Length (AA): 240 |
MW (Da): 27101 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
30 | 225 | 2wkq (A) | 525 | 720 | 78.00 | 0.00000057 | 1 | 1.84067 | -1.6 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126995)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G62880 | Rac-like GTP-binding protein ARAC10 |
Arabidopsis thaliana | AT2G17800 | Rac-like GTP-binding protein ARAC1 |
Arabidopsis thaliana | AT1G20090 | Rac-like GTP-binding protein ARAC4 |
Arabidopsis thaliana | AT4G35950 | Rac-like GTP-binding protein ARAC6 |
Arabidopsis thaliana | AT4G35020 | Rac-like GTP-binding protein ARAC3 |
Arabidopsis thaliana | AT5G45970 | Rac-like GTP-binding protein ARAC2 |
Arabidopsis thaliana | AT3G51300 | Rac-like GTP-binding protein ARAC11 |
Arabidopsis thaliana | AT2G44690 | Rac-like GTP-binding protein ARAC9 |
Arabidopsis thaliana | AT1G75840 | Rac-like GTP-binding protein ARAC5 |
Arabidopsis thaliana | AT3G48040 | Rac-like GTP-binding protein ARAC8 |
Brugia malayi | Bm1_34040 | small GTPase |
Brugia malayi | Bm1_00680 | Ras-related protein Rac1 |
Candida albicans | CaO19.6237 | one of two genes similar to S. cerevisiae CDC42 (YLR229C) rho family small monomeric GTPase |
Candida albicans | CaO19.13617 | one of two genes similar to S. cerevisiae CDC42 (YLR229C) rho family small monomeric GTPase |
Caenorhabditis elegans | CELE_K03D3.10 | Protein RAC-2 |
Caenorhabditis elegans | CELE_C35C5.4 | Protein MIG-2 |
Dictyostelium discoideum | DDB_G0268622 | Rho GTPase |
Dictyostelium discoideum | DDB_G0282365 | Rho GTPase |
Dictyostelium discoideum | DDB_G0279605 | Rho GTPase |
Dictyostelium discoideum | DDB_G0277869 | Rho GTPase |
Drosophila melanogaster | Dmel_CG2248 | CG2248 gene product from transcript CG2248-RB |
Drosophila melanogaster | Dmel_CG8556 | CG8556 gene product from transcript CG8556-RB |
Drosophila melanogaster | Dmel_CG5588 | Mig-2-like |
Echinococcus granulosus | EgrG_000261400 | ras C3 botulinum toxin substrate 2 |
Entamoeba histolytica | EHI_197840 | Rho family GTPase |
Entamoeba histolytica | EHI_129750 | Rho family GTPase |
Entamoeba histolytica | EHI_067220 | Rho family GTPase |
Entamoeba histolytica | EHI_181250 | Rho family GTPase |
Entamoeba histolytica | EHI_140190 | Rho family GTPase |
Entamoeba histolytica | EHI_012240 | Rho family GTPase |
Echinococcus multilocularis | EmuJ_000261400 | ras C3 botulinum toxin substrate 2 |
Echinococcus multilocularis | EmuJ_000522200 | Ras C3 botulinum toxin substrate 1 |
Giardia lamblia | GL50803_8496 | Rac/Rho-like protein |
Homo sapiens | ENSG00000169750 | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) |
Homo sapiens | ENSG00000136238 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
Homo sapiens | ENSG00000128340 | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) |
Loa Loa (eye worm) | LOAG_06394 | rac GTPase |
Loa Loa (eye worm) | LOAG_03639 | small GTPase |
Mus musculus | ENSMUSG00000001847 | RAS-related C3 botulinum substrate 1 |
Mus musculus | ensembl-mmu:ENSMUSG00000018012 | RAS-related C3 botulinum substrate 3 |
Mus musculus | ENSMUSG00000033220 | RAS-related C3 botulinum substrate 2 |
Oryza sativa | 4325879 | Os01g0229400 |
Oryza sativa | 4340590 | Os06g0234200 |
Oryza sativa | 4331272 | Os02g0834000 |
Oryza sativa | 4328116 | Os02g0120800 |
Oryza sativa | 4329132 | Os02g0312600 |
Oryza sativa | 4330693 | Os02g0742200 |
Onchocerca volvulus | OVOC5588 |
|
Schistosoma japonicum | Sjp_0207180 | Transforming protein RhoA precursor, putative |
Schistosoma japonicum | Sjp_0209090 | ko:K04392 Ras-related C3 botulinum toxin substrate 1, putative |
Schistosoma mansoni | Smp_062300.1 | rac gtpase |
Schistosoma mansoni | Smp_104110 | gtpase_rho |
Schmidtea mediterranea | mk4.012448.00 | Rho-related GTP-binding protein RhoH |
Schmidtea mediterranea | mk4.002609.02 | |
Schmidtea mediterranea | mk4.001607.06 | Rho-related GTP-binding protein RhoG |
Schmidtea mediterranea | mk4.001607.03 | Rho-related GTP-binding protein RhoG |
Schmidtea mediterranea | mk4.024013.00 | Rho-related GTP-binding protein RhoG |
Schmidtea mediterranea | mk4.013926.00 | Rho-related GTP-binding protein RhoG |
Schmidtea mediterranea | mk4.007124.00 | Rho-related GTP-binding protein RhoH |
Schmidtea mediterranea | mk4.004839.01 | Ras-like GTP-binding protein rhoA |
Schmidtea mediterranea | mk4.002609.01 | |
Schmidtea mediterranea | mk4.001607.04 | Rho-related GTP-binding protein RhoG |
Schmidtea mediterranea | mk4.019483.00 | Ras-like GTP-binding protein rhoA |
Trypanosoma cruzi | TcCLB.508351.50 | rho-like GTP binding protein, putative |
Trypanosoma cruzi | TcCLB.506649.40 | rho-like GTP binding protein, putative |
Trichomonas vaginalis | TVAG_572140 | rho5 protein, putative |
Trichomonas vaginalis | TVAG_462480 | rho4, putative |
Trichomonas vaginalis | TVAG_169060 | GTPase_rho, putative |
Trichomonas vaginalis | TVAG_272360 | rho4, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_K03D3.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | Compounds | References |