Detailed view for Bm1_29690

Basic information

TDR Targets ID: 242193
Brugia malayi, Protein kinase domain containing protein
Source Database / ID:  GenBank

pI: 9.2406 | Length (AA): 793 | MW (Da): 86250 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 281 2v7o (A) 0 272 35.00 0 1 0.763123 -0.45
10 323 3lij (A) 50 355 39.00 0 1 0.789565 -0.31
13 347 4lgd (D) 14 480 25.00 0 1 0.682046 0.23
39 339 3iec (A) 58 362 79.00 0 1 1.35717 -1.05
44 448 3soa (A) 27 418 26.00 0 1 0.613619 0.75
545 669 5a24 (A) 29 146 28.00 0.087 0.36 0.375829 -0.28
709 776 1z23 (A) 604 677 40.00 0.42 0.19 0.33695 0.02

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128024)

Species Accession Gene Product
Brugia malayi Bm1_29690   Protein kinase domain containing protein
Candida albicans CaO19.7510   likely protein kinase similar to S. cerevisiae KIN1 (YDR122W) and KIN2 (YLR096W)
Caenorhabditis elegans CELE_H39E23.1   Protein PAR-1, isoform I
Dictyostelium discoideum DDB_G0284661   CAMK1 family protein kinase
Dictyostelium discoideum DDB_G0292304   CAMKL family protein kinase
Dictyostelium discoideum DDB_G0281895   CAMKL family protein kinase
Echinococcus granulosus EgrG_000419700   serine:threonine protein kinase
Echinococcus granulosus EgrG_000428000   serine:threonine protein kinase MARK2
Echinococcus granulosus EgrG_000419600   serine:threonine protein kinase
Echinococcus granulosus EgrG_000754400   serine:threonine protein kinase MARK2
Echinococcus multilocularis EmuJ_000428000   serine:threonine protein kinase MARK2
Echinococcus multilocularis EmuJ_000419600   serine:threonine protein kinase
Echinococcus multilocularis EmuJ_000419700   serine:threonine protein kinase
Echinococcus multilocularis EmuJ_000754400   serine:threonine protein kinase MARK2
Homo sapiens ENSG00000007047   MAP/microtubule affinity-regulating kinase 4
Homo sapiens ENSG00000075413   MAP/microtubule affinity-regulating kinase 3
Homo sapiens ENSG00000116141   MAP/microtubule affinity-regulating kinase 1
Homo sapiens ENSG00000072518   MAP/microtubule affinity-regulating kinase 2
Loa Loa (eye worm) LOAG_07752   hypothetical protein
Loa Loa (eye worm) LOAG_12321   CAMK/CAMKL/MARK protein kinase
Mus musculus ENSMUSG00000030397   MAP/microtubule affinity-regulating kinase 4
Mus musculus ENSMUSG00000026620   MAP/microtubule affinity-regulating kinase 1
Mus musculus ENSMUSG00000024969   MAP/microtubule affinity-regulating kinase 2
Mus musculus ENSMUSG00000007411   MAP/microtubule affinity-regulating kinase 3
Saccharomyces cerevisiae YDR122W   Kin1p
Saccharomyces cerevisiae YLR096W   Kin2p
Schistosoma japonicum Sjp_0009970   ko:K08798 MAP/microtubule affinity-regulating kinase, putative
Schistosoma mansoni Smp_013840.2   serine/threonine protein kinase
Schistosoma mansoni Smp_013840.1   serine/threonine protein kinase
Schmidtea mediterranea mk4.001832.03  
Schmidtea mediterranea mk4.002636.05   Serine/threonine-protein kinase par-1
Schmidtea mediterranea mk4.006706.01  
Schmidtea mediterranea mk4.003498.00   Serine/threonine kinase
Schmidtea mediterranea mk4.018992.01  
Schmidtea mediterranea mk4.014961.00   Serine/threonine-protein kinase par-1
Schmidtea mediterranea mk4.000051.24  
Schmidtea mediterranea mk4.001832.04  
Schmidtea mediterranea mk4.012884.00   Serine/threonine-protein kinase par-1
Schmidtea mediterranea mk4.002636.04   Serine/threonine-protein kinase par-1
Schmidtea mediterranea mk4.006706.00   MAP/microtubule affinity-regulating kinase 4
Schmidtea mediterranea mk4.039044.00   Serine/threonine-protein kinase par-1
Schmidtea mediterranea mk4.007254.00  
Schmidtea mediterranea mk4.001624.03   Serine/threonine-protein kinase par-1
Trichomonas vaginalis TVAG_047030   CAMK family protein kinase

Essentiality

Bm1_29690 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_H39E23.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_H39E23.1 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens MAP/microtubule affinity-regulating kinase 1 Compounds References
Homo sapiens MAP/microtubule affinity-regulating kinase 3 Compounds References
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Compounds References
Homo sapiens MAP/microtubule affinity-regulating kinase 4 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Sus scrofa Casein kinase I isoform alpha 125 aa 28.8% 132 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 31.6% 152 aa Compounds References
Patiria pectinifera Cdc2 300 aa 30.0% 253 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0042 0.5 0.5
0.0026 0.5 0.5
0.0063 0.7244 0
0.0098 0.251 1
0.0004 0.5 0.5
0.026 0.4712 0.6034
0.0064 0.3377 0.3377
0.0098 0.251 1
0.0425 0.4802 1
0.0059 1 1
0.0056 1 1
0.0011 1 1
0.0062 0.6935 0.7231
0.0032 0.5 0.5
0.0018 0.5 0.5
0.0081 1 1
0.0059 1 1
0.0059 1 1
0.0078 0.251 1
0.0049 0.251 1
0.0098 0.3242 0.2614
0.0098 0.251 1
0.0098 0.251 1
0.0105 0.3439 0.3879
0.0067 0.5 0.5
0.0394 0.3618 0.3807
0.0098 0.251 1
0.0217 0.5586 1
0.0098 0.251 1
0.0098 0.251 1
0.0098 0.251 1
0.0106 0.3402 0.3869
0.0032 0.5 0.5
0.0007 0.5 0.5
0.0066 0.3101 0
0.0049 0.251 1
0.0012 0.5 0.5
0.0063 1 1
0.0027 1 1
0.0023 0.5 0.5
0.0022 0.5 0.5
0.0292 0.5374 1
0.025 0.251 1
0.0036 0.5 0.5
0.0262 0.3083 0.562
0.0106 0.2711 0.3907
0.0061 0.6883 0.6808
0.0521 0.251 1
0.0099 0.4362 1
0.0033 0.5 0.5
0.0105 0.3439 0.3879
0.0098 0.251 1
0.0081 0.5 0.5
0.0007 0.5 0.5
0.0037 1 0.5
0.0007 0.5 0.5
0.0098 0.251 1
0.0003 0.5 0.5
0.0098 0.251 1
0.0092 1 1
0.0384 0.251 1
0.0727 0.2516 1
0.026 0.4712 0.6034
0.0012 0.5 0.5
0.0016 0.5 0.5
0.0049 0.251 1
0.013 0.5294 1
0.0039 0.9485 1
0.0049 0.251 1
0.0039 0.5 0.5
0.0394 0.3618 0.3807
0.0098 0.251 1
0.0098 0.251 1
0.0098 0.251 1
0.0101 0.3104 0.4985
0.0098 0.251 1
0.0642 0.5555 1
0.0029 0.5 0.5
0.0425 0.4802 1
0.0039 0.5 0.5
0.0131 0.251 1
0.0091 1 1
0.0098 0.251 1
0.0367 0.251 1
0.0088 0.4477 0.4477
0.0093 0.8828 0
0.0049 0.373 1
0.0016 0.5 0.5
0.0012 0.5 0.5
0.0394 0.3618 0.3807
0.0008 0.5 0.5
0.0033 1 1
0.0069 0.3067 0.9179

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Bm1_29690 (Brugia malayi), Protein kinase domain containing protein
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