pI: 7.9655 |
Length (AA): 302 |
MW (Da): 35069 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_131212)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_04210 | Protein kinase domain containing protein |
Brugia malayi | Bm1_18080 | Protein kinase domain containing protein |
Caenorhabditis elegans | CELE_B0511.4 | Protein TAG-344 |
Caenorhabditis elegans | CELE_Y38H8A.4 | Protein Y38H8A.4 |
Caenorhabditis elegans | CELE_C27D6.11 | Protein C27D6.11 |
Drosophila melanogaster | Dmel_CG14305 | CG14305 gene product from transcript CG14305-RC |
Drosophila melanogaster | Dmel_CG9222 | CG9222 gene product from transcript CG9222-RA |
Homo sapiens | ENSG00000212122 | testis-specific serine kinase 1B |
Homo sapiens | ENSG00000206203 | testis-specific serine kinase 2 |
Loa Loa (eye worm) | LOAG_14842 | CAMK/TSSK protein kinase |
Loa Loa (eye worm) | LOAG_07107 | CAMK/TSSK protein kinase |
Loa Loa (eye worm) | LOAG_12998 | hypothetical protein |
Mus musculus | 22114 | testis-specific serine kinase 1 |
Mus musculus | ENSMUSG00000045521 | testis-specific serine kinase 2 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | testis-specific serine kinase 2 | Compounds | References |
Mus musculus | testis-specific serine kinase 1 | Compounds | References |
Homo sapiens | testis-specific serine kinase 1B | Compounds | References |
1 literature reference was collected for this gene.